The Effect of Cyproheptadine on Plasma Growth Hormone (GH) and on Somatostatin Response to GH-Releasing Hormone in Man

Abstract

Cyproheptadine (CPH)--a putative serotonin antagonist--is known to inhibit growth hormone (GH) response to various pharmacological stimuli, as well as during sleep. To elucidate the possible site at which this drug takes effect, we examined plasma GH and somatostatin response to i.v. GHRH1-44 (1 microgram/kg body wt.) before and after CPH treatment in 10 healthy volunteers. The oral administration of CPH (8-12 mg daily for 5 days; total dose 56 mg) significantly curbed GH response to GHRH as expressed in peak plasma GH values (32.0 +/- 6.1 micrograms/l vs. 12.6 +/- 3.2 micrograms/l; P less than 0.01) and in integrated GH response area (2368 +/- 517 micrograms x l-1 x 2 h vs. 744 +/- 172 micrograms x l-1 x 2 h; P less than 0.01). Plasma somatostatin levels did not change in response to GHRH.

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

“…Stimulatory effect of histamine on hypothalamus-induced growth hormone (GH) release was blocked by diphenhydramine [ 22 ]. Cyproheptadine has been shown to impair GH secretion following GH provocative tests [ 23 , 24 ], and was used in combination with bromocriptine in patients with acromegaly [ 25 ].…”

Resposta neuroendócrina aguda ao citalopram e resposta terapêutica no transtorno obsessivo-compulsivo

“…Estudos em humanos com antagonistas 5-HT, como a ciproheptadina e a metergolina, mostram diminuição dos níveis de GH (Chiodini et al 1976;Rosskamp et al, 1990). Também em humanos, ativação 5-HT1A e 5HT1D aumenta a secreção de GH (Pitchot et al, 2004.Pinessi et al, 2000.…”