The effect of cytotoxic therapy on saliva and oral flora

Main, B.; Calman, Kenneth C.; Ferguson, M.M.; Kaye, S. B.; MacFarlane, T. W.; Mairs, Robert J.; Samaranayake, LP; Willox, J.; Welsh, John

doi:10.1016/0030-4220(84)90077-x

Cited by 84 publications

(48 citation statements)

References 18 publications

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“…Lactobacilli levels also have been used, but they do not seem to be as effective as caries predictors as the S. mutans. [25][26][27][28] In this study, salivary Lactobacilli weren't statistically different in the study and reference groups that support the Wahlin and Holm [29] and Ou-Yang et al results. [12] The effects of chemotherapy on human salivary glands and the composition of human saliva are difficult to assess, and available information is relatively sparse and often contradictory.…”

Section: Discussionsupporting

confidence: 78%

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Bassir

2017

AJP

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Purpose: This study was aimed to evaluate the caries activity in children with acute lymphoblastic leukemia (ALL) undergoing maintenance stage chemotherapy courses. Materials and Methods: This is an observationalanalytical and case-control study conducted on the 27 children (4-12 years old) with ALL who were in the maintenance phase of chemotherapy in the Ahvaz Shafa Hospital, Iran. The participants of the control group, matched in terms of age, gender, and cultural status with the case group, were selected among the healthy children referred to Ahvaz Razi Hospital, Iran. The children received only a clinical dental examination without radiographs. The number of decayed (D), missing (M) and filled (F), and teeth (T) were recorded based on the WHO based DMFT index and without the use of radiography. Then, after radiographic assessment, the stimulated saliva samples were collected from the subjects to assess the salivary Streptococcus mutans counts, salivary Lactobacilli counts, and salivary buffer capacity. Results: The salivary S. mutans counts in ALL children were significantly higher than the control group (P < 0.001). In both groups, Lactobacilli counts and salivary pH and DMFT were similar (P > 0.05). Furthermore, the ALL group tended to have lower salivary flow rate than healthy subjects (P < 0.05). Conclusions: Specific oral prevention regimes should be planned with more cautions for children suffered hematology illness undergoing antineoplastic therapy with respect to children without blood problems.

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Section: Discussionsupporting

confidence: 78%

“…The rate fell significantly after 1-3 days and later rose to the level seen in the healthy persons. Main et al [27] found a continuous decrease in the salivary secretion rate in cancer patients after 3 months of treatment with cytotoxic drugs. The rate was lower than in healthy control subjects, which supported our findings.…”

Section: Discussionmentioning

confidence: 99%

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Bassir

2017

AJP

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“…15 The likelihood of the development of stomatitis from a drug is dependent on the agent, the dose and schedule of administration. Specific anticancer agents 16 that may cause stomatitis are depicted in Table 6. Table 5: Class of antiemetic used.…”

Section: Oral Toxicitymentioning

confidence: 99%

“…Since most patients are unaware of the toxicity, oral disease is common in subjects undergoing chemotherapy. The mucosa can be secondarily infected, if once ulcerated rendering a portal for systemic infection 16 . The normally proliferating epithelial lining is damaged and rate of renewal of mucosal lining is slowed.…”

Section: Oral Toxicitymentioning

confidence: 99%

Toxicities of anticancer drugs and its management

Remesh

2012

Int J Basic Clin Pharmacol

122

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One of the characteristics that distinguish anticancer agents from other drugs is the frequency and severity of side effects at therapeutic doses. Most cytotoxic drugs target rapidly multiplying cells and the putative targets are the nucleic acids and their precursors, which are rapidly synthesised during cell division. Many solid tumours have a lower growth fraction than the normal bone marrow, gastro intestinal lining, reticuloendothelial system and gonads. Drugs affect these tissues in a dose dependant manner and there is individual susceptibility also. So toxicities are more frequently associated with these tissues. The side effects may be acute or chronic, self-limited, permanent, mild or potentially life threatening. Management of these side effects is of utmost importance because they affect the treatment, tolerability and overall quality of life. This paper gives an overview of different toxicities of anticancer drugs and its management. [Int J Basic Clin Pharmacol 2012; 1(1.000): 2-12

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“…36 Carriage of oral Candida increases during radiotherapy for oral and laryngeal cancer 68 and cytotoxic therapy for solid tumours of oral and perioral regions. 69 …”

Section: Cytotoxic Therapy and Radiotherapy (Irradiation)mentioning

confidence: 99%

Host factors affecting oral candidiasis

Wyk

Steenkamp

2011

Southern African Journal of Epidemiology and Infection

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Review: Host factors affecting oral candidiasis Candida species are responsible for a wide range of systemic as well as superficial opportunistic infections, which are of particular importance among debilitated and immunocompromised patients. Species of the genus Candida comprise part of the oral commensal microflora of healthy individuals, with Candida albicans being the most common pathogen of the genus. A diverse array of host factors has been implicated in the pathogenesis of oral candidiasis. This paper describes the local, systemic and iatrogenic factors affecting oral candidiasis.Peer reviewed.

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The effect of cytotoxic therapy on saliva and oral flora

Cited by 84 publications

References 18 publications

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Toxicities of anticancer drugs and its management

Host factors affecting oral candidiasis

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