The effect of Dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance

Talaei, Afsaneh; Amini, Masoud; Siavash, Mansour; Zare, Maryam

doi:10.14310/horm.2002.1284

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…It may also modulate sex hormones in humans. Dehydroepiandrosterone sulfate (DHEA-S), which declines during normal aging, may serve as a potential longevity marker [14,15] and may improve insulin resistance [16-18]. Men with higher serum DHEA-S had a longer life span in a Baltimore longitudinal study of aging male humans [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of royal jelly ingestion for six months on healthy volunteers

Morita

Ikeda

Kajita

et al. 2012

Nutr J

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BackgroundRoyal jelly is a widely ingested supplement for health, but its effects on humans are not well known. The objective was to evaluate the effects of long-term royal jelly ingestion on humans.MethodsWe conducted a randomized placebo-controlled, double-blind trial. A total of 61 healthy volunteers aged 42-83 years were enrolled and were randomly divided into a royal jelly group (n = 31) and a control group (n = 30). Three thousand mg of royal jelly (RJ) or a placebo in 100 ml liquid/day were ingested for 6 months. The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after intervention.ResultsThirty subjects in the RJ group and 26 in the control group were included in the analysis of endpoints. In an adjusted mean change of the variables from the baseline, significant differences between the two groups could be found in red blood cell counts (+0.16x106 /μL for the RJ group vs. -0.01x106 /μL for the control group, P = 0.0134), hematocrit (+0.9% vs. -0.8%, P = 0.0251), log (fasting plasma glucose) (+0.01 ± 0.01 log mg/dL vs. +0.05 ± 0.01 log mg/dL, P = 0.0297), log (insulinogenic index) (+0.25 vs. -0.13, P = 0.0319), log dehydroepiandrosterone sulfate (DHEA-S) (+0.08 log μg/dL vs. +0.20 log μg/dL, P = 0.0483), log testosterone (T) (+0.12 ± 0.04 log ng/mL vs. -0.02 ± 0.05 log ng/mL, P = 0.0416), log T/DHEA-S ratio (+0.05 ± 0.05 vs. -0.23 ± 0.59, P = 0.0015), and in one of the SF-36 subscale scores, mental health (MH) (+4 vs. -7, P = 0.0276).ConclusionsSix-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration of conversion from DHEA-S to T by RJ may have been observed among these favorable effects.

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Section: Introductionmentioning

confidence: 99%

Effect of royal jelly ingestion for six months on healthy volunteers

Morita

Ikeda

Kajita

et al. 2012

Nutr J

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“…For the reproductive group, a negative correlation was found between Bacteroides and glucose levels and with sDHEA. Several studies have reported that dysbiosis involving the phylum Bacteroidetes , which harbors the genus Bacteroides, is related to glucose metabolism and the occurrence of type II diabetes mellitus in the adult population [ 60 , 61 ], and higher serum DHEAS levels have been correlated with better glucose uptake and improved insulin resistance in men, while for women, this benefit was not observed [ 62 , 63 ]. Our study suggests that higher glucose levels were found in the presence of a lower Bacteroides DNA copy number, corroborating a previous pilot study in elderly individuals [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study

et al. 2022

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Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identified the fecal microbiota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups according to the STRAW criteria for reproductive stage: reproductive (n = 18), premenopausal (n = 26), and postmenopausal (n = 58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifidobacterium, Bacteroides, Lactobacillus, and Clostridium. Results The following parameters showed differences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p < 0.05). qPCR revealed the genus Clostridium to be the most abundant in all three groups. In the reproductive age group, the significant correlations were: Bacteroides with glucose (r = -0.573 p = 0.0129), and SDHEA (r = -0.583 p = 0.0111). For the premenopausal group, they were: Bifidobacteria with total cholesterol (r = 0.396 p = 0.0451), LDL (r = 0.393 p = 0.0468), ApoB (r = 0.411 p = 0.0368); Lactobacillus and calcium (r = 0.443 p = 0.0232), ALP (r = 0.543 p = 0.0041), LPa (r =-0.442 p = 0.02336); and Bacteroides and urea (r =-0.461 p = 0.0176). In the postmenopausal group, they were Bifidobacterium and ALP (r =-0.315 p = 0.0159), Lactobacillus and urea (r =-0.276 p = 0.0356), and Clostridium and beta estradiol (r =-0.355 p = 0.0062). Conclusion In conclusion, the hormonal and metabolic changes during menopause in the population studied were accompanied by a significant change in the fecal microbiota, especially of the genus Clostridium.

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“…DHEA is as a source for the production of other hormones that the body needs like estrogens and testosterones, Though, DHEA have distinguishing and clear roles in the function of heart and blood vessels (Compagnone et al, 1997).The metabolism of DHEA is in the liver and mixed with Silver to change Dehydroepiandrosterone sulfate: DHEA-S is gained interest anti-depressant material, its positive effects on auto-immune diseases such as obesity, systemic lupus ,, ulcerative colitis, cancers and diabetes (Talaei et al,2010).…”

Section: Introductionmentioning

confidence: 99%

Estimation of dehydroepiandrosterone sulfate hormone (DHEA- S) as predictor of type 2 Diabetes Mellitus occurrence at AL-Najaf Province

Assi¹,

Raheem²,

Abdulkahaleq³

et al. 2021

ASRO

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The diabetic mellitus (DM) disease is a danger risk and a cause for rising public health anxietyat both develop and non-developing countries. T2DM is described by insulin resistances and/or abnormal insulin secretions from pancreas. Dehydroepiandrosterone sulfate: is a significant mammalian steroid hormone, the synthesis of this hormone from pregnenolone in the body. DHEA is a source of production of other hormones that the body need like estrogens and testosterone. Objectives: To study Serum DHEA-S hormone estimationas predictor of T2DM in relative with other limitations in diabetic patient. Material and Method: the study designed as case control experimental study was conducted on diabeticpatient at Al-Seder Hospital at AL-Najaf City-Iraq from February to April 2020. Results: the results of this study show there is significantly differences in (p< 0.05) between T2DM patients and control group, there is significant decrease in DHEA-S hormone levels at patient, while in regarding to thyroid hormones the T3 and T4 were significantly decrease on other hand TSH was increased. The lipid and sugar profiles were significantly increased at (P< 0.05). Conclusion: our study conducted There is a main relationship between DHEA-S hormone level and T2DM. This supports that DHEA-S level is reversely related with the diabetes progression.

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The effect of Dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance

Cited by 15 publications

References 25 publications

Effect of royal jelly ingestion for six months on healthy volunteers

Effect of royal jelly ingestion for six months on healthy volunteers

The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study

Estimation of dehydroepiandrosterone sulfate hormone (DHEA- S) as predictor of type 2 Diabetes Mellitus occurrence at AL-Najaf Province

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