The Effect of Dextran Molecular Weight on the Biodegradable Hydrogel with Oil, Synthesized by the Michael Addition Reaction

Omer, Rebaz; Hama, Jawameer Rasool; Rashid, Rebwar Saeed M.

doi:10.1002/adv.21629

Cited by 11 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cross‐linking density, polarity, and balance of hydrophobic and hydrophilic properties of the polymer chains are all factors that affect hydrogels' swelling. [ 62 ] The swelling ability increased when dextran was added to the pure PVA sample. As Table 2 shows, the gel fraction and crosslinking of pure PVA samples reduced by adding dextran.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of polyvinyl alcohol/dextran/Zataria wound dressing with superior antibacterial and antioxidant properties

Esfahani

Koupaei

Hassanzadeh-Tabrizi

2023

Vinyl Additive Technology

View full text Add to dashboard Cite

The aim of the present research was to synthesize and characterize polyvinyl alcohol/dextran/Zataria essential oil hydrogel wound dressings. For this purpose, dressings were made with different concentrations of polymers (PVA and Dex) and ZMO by solvent casting method. By dissolving PVA and Dextran in de-ionized water, PVA-Dex gel was made. The polymeric solution was mixed with glycerol. The pH of PVA-DEX-Glycerol solution was adjusted to 3 and glutaraldehyde was used as a cross-linker. ZMO, as the antibacterial and antioxidant agent, was added to the samples in different percentages (2,5,10%). It was found that both Dex and ZMO significantly influenced the hydrophilicity, gel fraction, and water uptake capacity of hydrogel films. The results showed that by the addition of Dex to PVA, the contact angle decreased from 48.54 ± 0.95 to 45.90 ± 0.73 , whereas by the addition of ZMO, the contact angle increased to 71.1 ± 2.43. SEM investigations revealed that the fabricated films had a uniform structure and the surface roughness increased with the addition of ZMO. The results indicated an increased elongation of 11.5% with the incorporation of ZMO into the films. The antimicrobial evaluation of the produced films showed that the loading of 10% v/v ZMO could broaden the microbicidal activity of PVA/Dex/ZMO film. The investigations on the interactions between synthesized wound dressings and fibroblast cells showed that the addition of ZMO into hydrogel films improved cell viability. The findings showed that PVA/Dex/ZMO films could have considerable use as wound dressing.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of polyvinyl alcohol/dextran/Zataria wound dressing with superior antibacterial and antioxidant properties

Esfahani

Koupaei

Hassanzadeh-Tabrizi

2023

Vinyl Additive Technology

View full text Add to dashboard Cite

show abstract

“…It is important that the moist environment created by a hydrogel dressing has an appropriate water vapor transmission rate, since only then it maintains the moisture content around the wound and promotes cell proliferation and wound healing [ 48 , 49 ]. When the water vapor transmission rate is too high, it tends to dry out the wound, which is not conducive to cell growth and the maintenance of a moist environment; furthermore, when the water vapor transmission rate is insufficient, it may allow exudate to accumulate on the wound, resulting in slow wound healing.…”

Section: Resultsmentioning

confidence: 99%

Essential Oil Nanoemulsion Hydrogel with Anti-Biofilm Activity for the Treatment of Infected Wounds

et al. 2023

View full text Add to dashboard Cite

The formation of a bacterial biofilm on an infected wound can impede drug penetration and greatly thwart the healing process. Thus, it is essential to develop a wound dressing that can inhibit the growth of and remove biofilms, facilitating the healing of infected wounds. In this study, optimized eucalyptus essential oil nanoemulsions (EEO NEs) were prepared from eucalyptus essential oil, Tween 80, anhydrous ethanol, and water. Afterward, they were combined with a hydrogel matrix physically cross-linked with Carbomer 940 (CBM) and carboxymethyl chitosan (CMC) to prepare eucalyptus essential oil nanoemulsion hydrogels (CBM/CMC/EEO NE). The physical-chemical properties, in vitro bacterial inhibition, and biocompatibility of EEO NE and CBM/CMC/EEO NE were extensively investigated and the infected wound models were proposed to validate the in vivo therapeutic efficacy of CBM/CMC/EEO NE. The results showed that the average particle size of EEO NE was 15.34 ± 3.77 nm with PDI ˂ 0.2, the minimum inhibitory concentration (MIC) of EEO NE was 15 mg/mL, and the minimum bactericidal concentration (MBC) against S. aureus was 25 mg/mL. The inhibition and clearance of EEO NE against S. aureus biofilm at 2×MIC concentrations were 77.530 ± 7.292% and 60.700 ± 3.341%, respectively, demonstrating high anti-biofilm activity in vitro. CBM/CMC/EEO NE exhibited good rheology, water retention, porosity, water vapor permeability, and biocompatibility, meeting the requirements for trauma dressings. In vivo experiments revealed that CBM/CMC/EEO NE effectively promoted wound healing, reduced the bacterial load of wounds, and accelerated the recovery of epidermal and dermal tissue cells. Moreover, CBM/CMC/EEO NE significantly down-regulated the expression of two inflammatory factors, IL-6 and TNF-α, and up-regulated three growth-promoting factors, TGF-β1, VEGF, and EGF. Thus, the CBM/CMC/EEO NE hydrogel effectively treated wounds infected with S. aureus, enhancing the healing process. It is expected to be a new clinical alternative for healing infected wounds in the future.

show abstract

“…FTIR analysis of the petroleum ether extract confirmed the presence of aliphatic compounds (2851 cm −1 and 2918 cm −1 ), a carbonyl group (1738 cm −1 ) and an ethoxylate (1108 cm −1 ). Based on the results obtained, the composition of preparations with a mass content of 0.1% consisted of fatty acid ethoxylates, as well as a small amount of silicone [ 39 , 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Biopolymer Textile Structure of Chitosan with Polyester

2022

View full text Add to dashboard Cite

The research deals with functionalization of a standard polyester fabric with biopolymer chitosan, whose premises are multifunctional and favour ecological effects. Due to the incompatibility of synthetic and natural polymers, the chitosan treatment was preceded by alkaline hydrolysis with sodium hydroxide with the addition of cationic and anionic surfactants as promoters. Compatibility of the chitosan with untreated and alkali-hydrolyzed fabrics was performed by analysis of mechanical and physico-chemical properties. The number of characterisation procedures performed required the use of hierarchical cluster analysis (HCA) to identify homogeneous groups or clusters in which similarities and differences between samples are visible. Almost all applied methods and evaluation parameters have shown that alkaline hydrolysis of polyester fabric has the best potential for functionalization with chitosan. Therefore, the addition of surfactants as promoters during alkaline hydrolysis is not necessary in the pretreatment process phase.

show abstract

The Effect of Dextran Molecular Weight on the Biodegradable Hydrogel with Oil, Synthesized by the Michael Addition Reaction

Cited by 11 publications

References 35 publications

Synthesis and characterization of polyvinyl alcohol/dextran/Zataria wound dressing with superior antibacterial and antioxidant properties

Synthesis and characterization of polyvinyl alcohol/dextran/Zataria wound dressing with superior antibacterial and antioxidant properties

Essential Oil Nanoemulsion Hydrogel with Anti-Biofilm Activity for the Treatment of Infected Wounds

Biopolymer Textile Structure of Chitosan with Polyester

Contact Info

Product

Resources

About