The effect of diclofenac and ketoprofen on halothane MAC in rabbit

Abstract

Non-steroidal anti-inflammatory drugs obviously act also on the central nervous system. We, therefore, studied the effect of diclofenac 3 mg/kg and ketoprofen 4 mg/kg on the minimum alveolar concentration (MAC) of halothane in 10 New Zealand White rabbits. After determination of halothane MAC, total doses of NSAIDs were administered intravenously as three subdoses: 12.5%, 37.5% and 50% of the total dose. Depth of anaesthesia did not increase significantly after the first two doses with either drug. With ketoprofen, halothane MAC increased after subdose 3 from 1.52 (SD 0.42) vol% to 1.9 (SD 0.36) vol% (p < 0.01). With diclofenac, halothane MAC increased after subdose 3 from 1.44 (SD 0.18) vol% to 1.60 (SD 0.39) vol% (ns). With both drugs, large interindividual differences of MAC appeared after full doses of NSAIDs.

Effect of morphine and flunixin meglumine on isoflurane minimum alveolar concentration in goats

“…Wide individual variability and inconsistent effects of dose on anesthetic MAC have been shown for NSAIDs (Rorarius et al. 1993).…”

Assessment of the analgesic effects of ketoprofen in ducks anesthetized with isoflurane

“…14 In mammals 15,16 and birds, 17,18 for instance, studies have shown that opioids reduce the requirement for inhalant anesthetics during anesthesia. However, NSAID have not been shown to reliably reduce the MAC of inhalant anesthetics in mammals or birds 16,17,19 ; therefore, we did not evaluate the effects of ketoprofen on the MAC of isoflurane in these birds.…”