The Effect of Diclofenac Sodium on Post Laparoscopy Pain

Preemptive Use of Diclofenac in Combination With Ketamine in Patients Undergoing Laparoscopic Cholecystectomy

“…13 Diclofenac has been reported to accumulate in inflamed tissues and to remain there for hours at much higher concentrations than those in plasma 14,15 ; in addition, it has active metabolites that also act as analgesics. As pain after laparoscopy may be due to distension of the abdomen resulting in peritoneal inflammation, 16 diclofenac may reduce peritoneal inflammation, thereby decrease sensitization of the peripheral nociceptors and consequently reduce the pain. The preemptive analgesic effect of diclofenac was supported in some 17,18 but not in other 19,20 clinical trials.…”