The effect of dietary menhaden, olive, and coconut oil fed with three levels of vitamin E on plasma and liver lipids and plasma fatty acid composition in rats

Mohamed, Ali I.; Hussein, Ahmed S.; Bhathena, Sam J.; Hafez, Y. S.

doi:10.1016/s0955-2863(02)00196-1

Cited by 42 publications

(25 citation statements)

References 32 publications

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“…Mohamed et al [36] have demonstrated that serum concentration of oleic acid, a major component of olive oil, increased in rats given olive oil. Furthermore, oleic acid is hardly oxidized compared with other unsaturated fatty acids.…”

Section: Effects Of Oleic Acid On Hscmentioning

confidence: 99%

Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

et al. 2009

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Section: Effects Of Oleic Acid On Hscmentioning

confidence: 99%

Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

et al. 2009

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“…This pharmacodynamic effect is reported to be dose dependent (25) hence, was used as a basis for the comparison of in vivo performance of pure SIM and SD 1:2:2. Administration of excess coconut oil, which is a rich source of saturated fatty acids, promotes biosynthesis of cholesterol in liver and leads to hypercholesterolemia (26,27). The serum lipid profiles of all the experimental groups at different time intervals are presented in Table IV and the corresponding % changes in lipid profiles are plotted in Figs.…”

Section: In Vivo Study In Ratsmentioning

confidence: 99%

Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug: In Vitro and in Vivo Evaluations

2005

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“…The diet fatty acids composition is known to influence the fatty acid composition of stored and structural lipids in the body [35] [36].…”

Section: Discussionmentioning

confidence: 99%

Soybean Flour Improves Fatty Acid Profile and Decreases Hepatic Triglyceride Deposition in Rats Fed with Normocaloric and Hypercaloric Diet

Razzeto¹,

López²,

Marra³

et al. 2015

FNS

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This study investigated the effects of replacing casein with soy flour on the fatty acids profile and triglycerides metabolism in the liver of rats that were previously fed with normocaloric and hypercaloric diets based on casein. Wistar male rats were used; one group was fed with control diet (AIN-93) and another with hypercaloric diet (AIN-93 with 34.15% sucrose, 42% fat calories) for 9 weeks. Each group was then divided into two subgroups and casein was replaced with soybean in one of them, obtaining CC (control casein), CS (control soy), HC (hypercaloric casein) and HS (hypercaloric soy), which were fed for 6 weeks. We measured triglycerides in serum, and triglycerides, total lipids, fatty acids profile, the expression of apolipoprotein B (Apo B), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), sterol-regulatory element-binding protein 1c (SREBP1c), mitochondrial glycerol-3-phosphate acyltransferase (mGPAT), diacylglycerol acyltransferase 2 (DGAT-2), carnitine palmitoyltransferase 1 (CPT-1) and peroxisome proliferator-activated receptors alpha (PPARα) in liver. Histological studies were also performed. When comparing HS vs. HC, a positive effect of soybean flour on hepatic triglycerides deposits was found, possibly through the reduction in DGAT-2 expression (P < 0.01) and the increase in Apo B (P < 0.001) expression. Soybean flour also decreased fat deposits in control diets when compared with casein, decreasing the DGAT-2 (P < 0.001) expression and increasing Apo B (P < 0.001), CPT-1 (P < 0.05) and PPARα (P < 0.01) expressions. Both soy diet subgroups increased unsaturated fatty acids respect to casein diets (P < 0.01). Hepatocytes showed few lipid droplets in HS, whereas a fat deposit in HC was ob-* Corresponding author.G. S. Razzeto et al. 1246 served. These results suggest that replacing casein with soybean flour in normocaloric and hypercaloric diets reduces triglycerides and improves fatty acids profile in rat liver.

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The effect of dietary menhaden, olive, and coconut oil fed with three levels of vitamin E on plasma and liver lipids and plasma fatty acid composition in rats

Cited by 42 publications

References 32 publications

Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice

Spray-Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg Drug: In Vitro and in Vivo Evaluations

Soybean Flour Improves Fatty Acid Profile and Decreases Hepatic Triglyceride Deposition in Rats Fed with Normocaloric and Hypercaloric Diet

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