The effect of dietary soyabean isoflavones on photodynamic therapy in K562 leukemia cells

Zhang, Sujuan; Hao, Jinbo; Wei, Yiran; Yin, Lingfeng; Liu, Xiao

doi:10.1016/j.jphotobiol.2012.02.006

Cited by 13 publications

(11 citation statements)

References 39 publications

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“…The antioxidants which can scavenge singlet oxygen may decrease the effectiveness of PDT (such as vitamin C (Frank et al 2006)). The antioxidants which increase the amounts of singlet oxygen may exhibit a synergistic effect on PDT (such as genistein (Zhang et al 2012), EA (in this research)).…”

Section: Discussionmentioning

confidence: 81%

“…Peter Ferenc and colleagues (Ferenc et al 2010) demonstrated that pre-treatment with tyrosine kinase inhibitor genistein may significantly improve the effectiveness of PDT with hypericin in MCF-7 and MDA-MB-231 breast cancer cells. Our previous study (Zhang et al 2012) found the soyabean isoflavones genistein and daidzein did not decrease the effectiveness of cancer therapy on malignant cells.…”

Section: Discussionmentioning

confidence: 89%

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The effect of ellagic acid on photodynamic therapy in leukemia cells

Lü¹,

Zhang²,

Wang³

et al. 2018

gpb

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Ellagic acid (EA) is a naturally phenolic acid presented in different foods. It has a variety of biological activities including antioxidant, anti-inflammatory, anti-microbiological and anti-cancer properties. On account of its antioxidant activity, EA might protect cancer cells from free radical damage in photodynamic therapy (PDT) during which reactive oxygen species (ROS) production was stimulated leading to irreversible tumor cell injury. In this study, the influence of EA on K562 cells in 5-aminolevulinic acid (ALA)-based PDT is demonstrated. Cell apoptosis was assayed by flow cytometry. Oxidative damage induced by PDT was investigated by measurement of malondialdehyde (MDA). Comet assay was used to evaluate the potential genotoxic effect induced by PDT on the cells. The results showed that EA supplementation alone did not affect the lipid peroxidation, DNA damage and apoptosis in K562 cells. It increases the lipid peroxidation, DNA damage, apoptosis and decreases the survival rate in K562 cells induced by ALA-PDT. The singlet oxygen quencher sodium azide suppresses apoptosis, lipid peroxidation and DNA damage induced by EA in PDT. In conclusion, EA consumption during PDT did not decrease the effectiveness of cancer therapy on malignant cells. The effect of antioxidants on PDT maybe was determined by its sensitization ability to singlet oxygen.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 89%

The effect of ellagic acid on photodynamic therapy in leukemia cells

Lü¹,

Zhang²,

Wang³

et al. 2018

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“…Tumor cell death by apoptosis after PDT has been investigated (Chiu and Oleinick, ), treatment with different concentrations of flavonoid (Duo et al, ), and after PDT in combination with flavonoids (Zhang et al, ). However, in necrotic cell death induced by PDT, acute and located inflammatory reaction occur that participates in the removal of dead cells, restoring normal tissue homeostasis and leading to the development of systemic immunity for effective destruction of metastases (Agostinis et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of photodynamic therapy supplemented with quercetin in HEp‐2 cells

Rodrigues

Tini

Soares

et al. 2014

Cell Biology International

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Photodynamic therapy (PDT) is a technique that can be used as a complementary therapy in cancer treatment combined with other therapeutic modalities. Quercetin (QCT) is known to be effective in the treatment of cancer, by reducing the cell viability of different cancer cell lines. This study aimed to evaluate the influence of different concentrations of QCT in PDT on the viability, mitochondrial membrane potential and induction of apoptosis/necrosis in the human larynx carcinoma cells (HEp-2). The HEp-2 cells were treated with aluminum phthalocyanine tetrasulfonate (AlPcS4) and QCT and subsequently irradiated with a diode laser light (685 nm, 35 mW, 4.5 J/cm(2)). The results demonstrated that treatment of HEp-2 cells with high concentrations of QCT (at least 50 μM) reduced cell viability. This response was enhanced in cells subjected to PDT supplemented with high concentrations of QCT. In addition, was observed decrease in the mitochondrial membrane potential and characteristics of late apoptosis and/or initial necrosis process. QCT at concentrations from 50 μM improves PDT-induced cytotoxicity by significantly reducing cell viability by apoptosis and/or necrosis, and mitochondrial membrane potential of Hep-2 cells.

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“…Daidzein inhibited the cell growth of K562/BCRP cells in the presence of SN-38 but to a lesser extent than genistein [101]. Genistein (10 μM) alone did not reduce the cell viability of MCF-7 breast cancer cells following 72 h incubation [125], whereas 48 h incubation of K562 leukemia cells with genistein (10–100 μM) modestly reduced cell viability by about 15% [126]. The inconsistency of these findings may arise from innate differences in the protective mechanisms of each cell type.…”

Section: Evidence For Isoflavones As Inhibitors Of Bcrp Functionmentioning

confidence: 99%

“…Additionally, two different methods were used to detect cell viability. Zhang et al utilized a more sensitive and direct measure of cell viability, trypan blue, which quantified the number of viable cells [126], while Pick et al drew conclusions based on the ATP assay which indirectly indicates the amount of ATP generated which was positively correlated with cell viability [125]. …”

Section: Evidence For Isoflavones As Inhibitors Of Bcrp Functionmentioning

confidence: 99%

Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter

Bircsak¹,

Aleksunes²

2015

CDM

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This review will provide a comprehensive overview of the interactions between dietary isoflavones and the ATP-binding cassette (ABC) G2 efflux transporter, which is also named the breast cancer resistance protein (BCRP). Expressed in a variety of organs including the liver, kidneys, intestine, and placenta, BCRP mediates the disposition and excretion of numerous endogenous chemicals and xenobiotics. Isoflavones are a class of naturally-occurring compounds that are found at high concentrations in commonly consumed foods and dietary supplements. A number of isoflavones, including genistein and daidzein and their metabolites, interact with BCRP as substrates, inhibitors, and/or modulators of gene expression. To date, a variety of model systems have been employed to study the ability of isoflavones to serve as substrates and inhibitors of BCRP; these include whole cells, inverted plasma membrane vesicles, in situ organ perfusion, as well as in vivo rodent and sheep models. Evidence suggests that BCRP plays a role in mediating the disposition of isoflavones and in particular, their conjugated forms. Furthermore, as inhibitors, these compounds may aid in reversing multidrug resistance and sensitizing cancer cells to chemotherapeutic drugs. This review will also highlight the consequences of altered BCRP expression and/or function on the pharmacokinetics and toxicity of chemicals following isoflavone exposure.

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The effect of dietary soyabean isoflavones on photodynamic therapy in K562 leukemia cells

Cited by 13 publications

References 39 publications

The effect of ellagic acid on photodynamic therapy in leukemia cells

The effect of ellagic acid on photodynamic therapy in leukemia cells

Effect of photodynamic therapy supplemented with quercetin in HEp‐2 cells

Interaction of Isoflavones with the BCRP/ABCG2 Drug Transporter

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