The effect of different proportions of casein in semipurified diets on the concentration of serum cholesterol and the lipoprotein composition in rabbits

Terpstra, A.H.M.; Harkes, L.; Veen, Frederik H. van der

doi:10.1007/bf02535684

Cited by 65 publications

(19 citation statements)

References 19 publications

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“…ported in the VLDL fraction [9]. However, we have found quite different results in lean Zucker rats.…”

Section: Discussioncontrasting

confidence: 46%

Serum Lipids, Lipoprotein Composition and Liver Cholesterol in Genetically Obese Zucker Rats Fed Semipurified Diets Containing either Casein or Soy Protein

Terpstra¹,

Tintelen²,

West³

1983

Ann Nutr Metab

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The effect of semipurified diets containing either casein or soy protein on serum lipids, lipoprotein composition and liver cholesterol was studied in genetically obese Zucker rats. The ingestion of a cholesterol-enriched semipurified diet containing casein resulted in elevated levels of serum cholesterol and phospholipids compared to the feeding of a soy protein diet. No differences in serum triglycerides were observed. Differences in serum cholesterol and phospholipids were mainly reflected in the very low density lipoproteins and low density lipoproteins and to a minor extent in the high density lipoproteins. Liver cholesterol paralleled the levels of cholesterol in the serum, the rats fed casein exhibited markedly higher levels of liver cholesterol than those fed soy protein. Furthermore, the rats fed casein also had enlarged livers. Thus, this study clearly shows the differential cholesterolemic effect of dietary casein and soy protein in genetically obese Zucker rats.

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“…ported in the VLDL fraction [9]. However, we have found quite different results in lean Zucker rats.…”

Section: Discussioncontrasting

confidence: 46%

Serum Lipids, Lipoprotein Composition and Liver Cholesterol in Genetically Obese Zucker Rats Fed Semipurified Diets Containing either Casein or Soy Protein

Terpstra¹,

Tintelen²,

West³

1983

Ann Nutr Metab

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“…The reverse increase in TC concentration after week 4 in the milk protein group may have been due to casein being used as the major protein component in this group. Casein has been found to be more hypercholesterolaemic than soya protein (Terpstra et al 1981;Kurowska & Carroll, 1990). Furthermore, the time-by-treatment interaction was significant in the soya protein group, and there was a significant reduction in TC from baseline compared with the milk protein group.…”

Section: Discussionmentioning

confidence: 96%

Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Chen

Yang

et al. 2006

Br J Nutr

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Clinical trials have shown that soya protein reduces the concentrations of some atherogenic lipids in subjects with normal renal function. The present study examined the effects of soya protein on serum lipid concentrations and lipoprotein metabolism in patients on hypercholesterolaemic haemodialysis. Twenty-six hypercholesterolaemic (total cholesterol $ 6·21 mmol/l) patients on haemodialysis were studied in a randomized, double-blind, placebo-controlled clinical trial. After a 4-week run-in phase, the subjects were randomly assigned to two groups. Isolated soya protein or milk protein 30 g was consumed daily as a beverage at breakfast or post-dialysis for 12 weeks. Soya protein substitution resulted in significant reductions in total cholesterol (17·2 (SD 8·9 )%), LDL-cholesterol (15·3 (SD 12·5 )%), apo B (14·6 (SD 12·1 )%) and insulin (23·8 (SD 18·7) %) concentrations. There were no significant changes in HDL-cholesterol or apo A-I. These results indicate that replacing part of the daily protein intake with soya protein has a beneficial effect on atherogenic lipids and favourably affects lipoprotein metabolism in hypercholesterolaemic patients undergoing haemodialysis.

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“…Terpstra and colleagues reported similar results, but their data also demonstrated the dose effect of casein fed to Zucker strain rats [46]. Their study included six groups of animals fed with either a commercial diet with no cholesterol, a commercial diet with 1.2 % cholesterol, or four types of semi-purified cholesterol enriched diets (20 % casein, 50 % casein, 20 % soybean, or 50 % soybean (g/100 g of feed)).…”

Section: The Effects Of Casein In the Animal Modelmentioning

confidence: 54%

The role of casein in the development of hypercholesterolemia

2014

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Atherosclerosis remains the leading cause of severe cardiovascular complications such as cardio- and cerebrovascular events. Given that prevention and early intervention play important roles in the reduction of cardiovascular complications associated with atherosclerosis, it is critical to better understand how to target the modifiable risk factors, such as diet, in order to best minimize their contributions to the development of the disease. Studies have shown that various dietary sources of protein can affect blood lipid levels, a modifiable risk factor for atherosclerosis, either positively or negatively. This clearly highlights that not all proteins are "created equal." For example, consumption of diets high in either animal- or vegetable-based sources of protein have resulted in varied and inconsistent effects on blood cholesterol levels, often depending on the amino acid composition of the protein and the species investigated. Careful consideration of the source of dietary protein may play an important role in the prevention of atherosclerosis and subsequent cardiovascular complications. Given the recent focus on high protein diets, an emphasis on controlled studies in the area is warranted. The goal of this review is to present the current state of the literature that examines the effects of casein, a commonly utilized animal-based protein, on blood cholesterol levels and the varying effects noted in both animals and humans.

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The effect of different proportions of casein in semipurified diets on the concentration of serum cholesterol and the lipoprotein composition in rabbits

Cited by 65 publications

References 19 publications

Serum Lipids, Lipoprotein Composition and Liver Cholesterol in Genetically Obese Zucker Rats Fed Semipurified Diets Containing either Casein or Soy Protein

Serum Lipids, Lipoprotein Composition and Liver Cholesterol in Genetically Obese Zucker Rats Fed Semipurified Diets Containing either Casein or Soy Protein

Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

The role of casein in the development of hypercholesterolemia

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