The Effect of Diltiazem on Microcirculation of Trans-planted Tissue Flaps: Experimental Study on Rabbits

Davudov, Mahammad M.; Musayev, Jamal; Hasanov, Adalat; Fathi, Hamid Reza

doi:10.52547/wjps.10.2.61

Cited by 2 publications

(2 citation statements)

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“…Irradiation can obliterate blood vessels, potentially causing tissue hypoxia, hypovascularization, hypocellularity, fibrosis, and bone necrosis in the irradiated area 23 . Primary goals of surgical treatment include excision of all necrotic and heavily scarred tissue and replacement with nonirradiated, well-vascularized tissue 19 .…”

Section: Discussionmentioning

confidence: 99%

Head and Neck Reconstruction With 2-Stage External Pectoralis Major Myocutaneous Flap Transfer

et al. 2023

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BackgroundIn head and neck surgery cases where skin is severely scarred or adhered to surrounding tissue, reconstruction can be difficult to perform using microsurgical tissue or conventional pedicled pectoralis major myocutaneous flap (PMMF) transfer given the risks, which include damage to major vessels when manipulating scarred skin. For such cases, we perform a 2-stage external PMMF transfer, whereby the PMMF is directly sutured to the defect over the neck skin (without manipulation the hardened skin), and the flap division is then performed secondarily.MethodsA total of 30 patients who had histories of radiotherapy (60–70 Gy) and prior neck dissection received the 2-stage external PMMF transfer procedure. Indications for the flaps included pharyngeal fistula closure in 12 patients, reconstruction for mandibular necrosis after radiotherapy in 8 patients, salvage surgery for partial or total necrosis of the free flap in 4 patients, and simultaneous reconstruction after tumor excision in 6 patients. Two patients underwent a second external PMMF transfer from the contralateral side because of postoperative complications, yielding a total of 32 flap transfers.ResultsTwenty-nine flaps showed complete flap survival, whereas 3 had partial necrosis. Other complications, despite complete flap survival, included large fistulas requiring additional surgery for fistula closure (1 patient) and small fistulas that were closed without requiring reoperation (7 patients).ConclusionsExternal PMMF transfer offers a safe, simple, and effective option in cases where free flap surgery is considered difficult or the risks associated with neck manipulation are high.

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Section: Discussionmentioning

confidence: 99%

Head and Neck Reconstruction With 2-Stage External Pectoralis Major Myocutaneous Flap Transfer

et al. 2023

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“…Kenney and Kiil [ 62 ] reported 4 cases using fascia-sparing vertical rectus abdominis musculocutaneous flaps combined with a vascularized-free fibula graft to reconstruct advanced mandibular osteoradionecrosis. This year, pectoralis major musculocutaneus and deltopectoral flaps, as well as bilobed trapezius myocutaneous flaps, were reported to be implemented in the reconstruction of the irradiated mandible[ 63 , 64 ]. When common flaps such as fibular flaps and iliac crest flaps are not available, these flaps may bring new options to choose from.…”

Section: Reconstruction Of An Orn-caused Mandibular Segmental Defect ...mentioning

confidence: 99%

The Progress in Reconstruction of Mandibular Defect Caused by Osteoradionecrosis

Huang

Wang

Gong

et al. 2023

Journal of Oncology

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Osteoradionecrosis (ORN) is described as a disease with exposed, nonviable bone that fails to heal spontaneously or by means of conservative treatment after radiotherapy in at least 3 months. Though traditional theories in the early stage including hypoxic-hypocellular-hypovascular and fibro-atrophic in addition to new findings such as ferroptosis were put forward to explain the mechanisms of the osteoradionecrosis, the etiology of ORN is still unclear. With the high rate of occurrence in the head and neck area, especially in the mandible, this disease can disrupt the shape and function of the irradiated area, leading to a clinical presentation ranging from stable small areas of asymptomatic exposed bone to severe progressive necrosis. In severe cases, patients may experience pain, xerostomia, dysphagia, facial fistulas, and even a jaw defect. Consequently, sequence therapy and sometimes extensive surgery and reconstructions are needed to manage these sequelae. Treatment options may include pain medication, antibiotics, the removal of sequesters, hyperbaric oxygen therapy, segmental resection of the mandible, and free flap reconstruction. Microanastomosed free-flaps are considered to be promising choice for ORN reconstruction in recent researches, and new methods including three-dimensional (3-D) printing, pentoxifylline, and amifostine are used nowadays in trying increase the success rates and improve quality of the reconstruction. This review summarizes the main research progress in osteoradionecrosis and reconstruction treatment of osteoradionecrosis with mandibular defect.

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The Effect of Diltiazem on Microcirculation of Trans-planted Tissue Flaps: Experimental Study on Rabbits

Abstract: BACKGROUNDThe aim of the presented study was to investigate the inhibitory effect of diltiazem on the microcirculation of the tissue flaps created in the delay phenomenon applied rabbits. METHODSThe experiment was performed in

Cited by 2 publications

References 14 publications

Head and Neck Reconstruction With 2-Stage External Pectoralis Major Myocutaneous Flap Transfer

Head and Neck Reconstruction With 2-Stage External Pectoralis Major Myocutaneous Flap Transfer

The Progress in Reconstruction of Mandibular Defect Caused by Osteoradionecrosis

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