The effect of disodium cromoglycate on the release of histamine and degranulation of rat mast cells induced by compound

Orr, T. S. C.; Hall, D.E.; Guilliam, Jessie M.; Cox, J.S.G.

doi:10.1016/0024-3205(71)90035-x

Cited by 98 publications

(41 citation statements)

References 10 publications

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“…74,917 was administered intradermally (Table 2). Neither compound was active when given intravenously, which conflicts with the finding of Orr, Hall, Gwilliam & Cox (1971) (Assem, 1973;Taylor & Roitt, 1973) have shown that DSCG inhibits certain allergic reactions in the guinea-pig, no consistent or significant inhibitory activity was found in the present work at intravenous doses up to 50 mg/kg. In contrast, I.C.I.…”

Section: Ol_contrasting

confidence: 99%

Inhibition of Immediate Hypersensitivity Reactions in Laboratory Animals by a Phenanthroline Salt (Ici 74,917)

Evans

Thomson

1975

British J Pharmacology

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1 The activity of a new anti-allergic compound, I.C.I. 74,917, has been studied in the rat, mouse and guinea-pig.2 Following intravenous administration, I.C.I. 74,917 inhibits in a dose-dependent manner passive cutaneous anaphylaxis induced in rats and mice by heat-labile homocytotropic antibody. In rats, its potency is approximately 300 times that of disodium cromoglycate. 3 To achieve maximal inhibition, it is necessary to administer I.C.I. 74,917 at the same time as antigenic challenge; dosing before or after challenge has much less effect. 4 Liberation of histamine, provoked by the antigenic challenge of mast cells passively sensitized in vitro by IgE-like antibody, is reduced in the presence of I.C.I. 74,917. 5Intravenous administration of the compound has no significant effect upon local blueing reactions provoked in the rat by intradermal injection of histamine, 5-hydroxytryptamine or Compound 48/80. It has only a slight effect at high doses upon passive cutaneous anaphylaxis induced in the rat by heat-stable homocytotropic or heterologous (guinea-pig) antibodies. 6 Although not a bronchodilator in the guinea-pig, I.C.I. 74,917 partially inhibits systemic anaphylaxis. A consistent reduction in the severity of antigen-induced bronchospasm was demonstrated in the Konzett-R6ssler preparation at doses comparable to those inhibiting passive cutaneous anaphylaxis in the rat. However, there was only slight inhibition of passive cutaneous anaphylaxis in the guinea-pig. 7 I.C.I. 74,917 itself induces bronchospasm when administered to anaesthetized guinea-pigs or to a guinea-pig isolated lung preparation. This effect is reversed by salbutamol, but is not prevented by the prior administration of mepyramine, atropine or methysergide. 8 These results indicate that in the rat, mouse and guinea-pig, I.C.I. 74,917 is a potent inhibitor of certain types of immediate hypersensitivity reactions.

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Section: Ol_contrasting

confidence: 99%

Inhibition of Immediate Hypersensitivity Reactions in Laboratory Animals by a Phenanthroline Salt (Ici 74,917)

Evans

Thomson

1975

British J Pharmacology

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“…It has been reported that the degree of inhibition by DSCG of the histamine secretion depends on the intensity of the control response (3,7). In the present study, DSCG (10-5 M) had a significant inhibitory effect on the histamine secretion induced by sub stance P (10-6-2X10-5 M) in Ca2+ containing medium.…”

Section: Resultssupporting

confidence: 54%

“…It effectively inhibits histamine release (secretion) from rat peritoneal mast cells as induced by the binding of a specific antigen to cell-bound IgE antibody (3)(4)(5) as well as by a variety of chemical substances such as dextran (5), compound 48/80 (3,(6)(7)(8), substance P (8) and neurotensin (8). Possible mechanisms of the action of DSCG include: blocking of the influx of Ca 21 into mast cells (6,9), in hibition of phosphodiesterase (10, 11) and regulation of phosphorylation of mast cell protein (12).…”

mentioning

confidence: 99%

Disodium cromoglycate inhibition of substance P-induced histamine secretion is calcium dependent.

Nishibori

Saeki

1983

Jpn.J.Pharmacol

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Abstract-Histamine secretion was induced by substance P, in a dose-dependent manner, from rat peritoneal mast cells, both in the presence and absence of Ca 21 in the medium, and disodium cromoglycate (DSCG) produced a dose-dependent inhibition of the histamine secretion in Ca2+-containing medium. However, in the absence of Ca2+, DSCG was ineffective or had a far weaker activity. Mgt+, Sr2+ and Ba21 were ineffective in restoring the DSCG activity when added to medium devoid of divalent metal ions. Therefore, extracellular Ca 21 seems to be a specific requirement for the binding of DSCG to its "receptors" on the mast cell surface or some steps in the DSCG action.

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“…Disodium cromoglycate has been shown to inhibit the exocytosis of mast cells stimulated with various agents such as anti-gen, 24 compound 48/80, 23 " 26 dextran, 2 7 neurotensin2' and dynorphin. 22 The histamine release by VVH was slightly inhibited by disodium cromoglycate, but this inhibition was not dosedependent, and the maximal effect was 35% reduction.…”

Section: Discussionmentioning

confidence: 99%

Cytolytic action of Vibrio vulnificus haemolysin on mast cells from rat peritoneal cavity

Yamanaka

Sugiyama

Furuta

et al. 1990

Journal of Medical Microbiology

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Summary. The mode of action of Vibrio vulnifcus haemolysin (VVH) on mast cells from the peritoneal cavity of the rat was examined. VVH induced histamine release, and damage to the mast cells, in a dose-dependent fashion. When 1 pg of VVH was added to c. lo5 mast cells at 37"C, histamine release was observed after a lag period of 5-10 s, and was complete within 5 min. The action was temperature-dependent, and was not induced at 4°C. Disodium cromoglycate, a membrane stabiliser for mast cells, inhibited the histamine release significantly, but the effect was not dosedependent. Moreover, leakage of lactate dehydrogenase from VVH-treated mast cells was observed. These results suggest that VVH acts on the cell membrane of mast cells and is cytolytic.

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The effect of disodium cromoglycate on the release of histamine and degranulation of rat mast cells induced by compound

Cited by 98 publications

References 10 publications

Inhibition of Immediate Hypersensitivity Reactions in Laboratory Animals by a Phenanthroline Salt (Ici 74,917)

Inhibition of Immediate Hypersensitivity Reactions in Laboratory Animals by a Phenanthroline Salt (Ici 74,917)

Disodium cromoglycate inhibition of substance P-induced histamine secretion is calcium dependent.

Cytolytic action of Vibrio vulnificus haemolysin on mast cells from rat peritoneal cavity

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