The effect of dopamine receptor blockade in the rodent nucleus accumbens on local field potential oscillations and motor activity in response to ketamine

Matulewicz, Paweł; Kasicki, S; Hunt, Mark J.

doi:10.1016/j.brainres.2010.09.088

Cited by 28 publications

(20 citation statements)

References 46 publications

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“…The detected time spent in active and inactive states could deviate slightly from the true time spent in the two states as the developed state‐detection algorithm rejected ~23% of data as “behaviourally indistinct,” however, the detected changes in video scored locomotor activity were similar to those assessed with infrared beam breaks. Our findings align with previous investigations in rats showing increases in locomotor activity at ketamine doses of ≥ 12 mg/kg (Caixeta et al., ; Hunt et al., ; Imre et al., ; Matulewicz et al., ; Nicolás et al., ; Páleníček et al., ), decreases (Cordon et al., ; Kealy et al., ; Kocsis, ; Nicolás et al., ) or no change (Engin, Treit, & Dickson, ; Gigliucci et al., ) at 10 mg/kg, and mainly no effect at doses between 0.25 and 5 mg/kg (Akinfiresoye & Tizabi, ; Imre et al., ; Réus et al., ; Tizabi, Bhatti, Manaye, Das, & Akinfiresoye, ).…”

Section: Discussionsupporting

confidence: 92%

“…Hyperlocomotion‐related effects on ECoG/LFP can i.a. be expected in animal pharmaco‐EEG studies investigating models of NMDAR hypofunction (Goff, ), since commonly used non‐competitive NMDAR antagonists, such as ketamine, may induce hyperlocomotion in rodents (Caixeta, Cornélio, Scheffer‐Teixeira, Ribeiro, & Tort, ; Hunt, Raynaud, & Garcia, ; Imre, Fokkema, Den Boer, & Ter Horst, ; Matulewicz, Kasicki, & Hunt, ; Nicolás et al., ; Páleníček et al., ). In contemporary schizophrenia research, neuronal oscillations have received much attention.…”

Section: Introductionmentioning

confidence: 99%

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Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Hansen

Agerskov

Arvastson

et al. 2019

Eur J of Neuroscience

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Quantitative electroencephalography from freely moving rats is commonly used as a translational tool for predicting drug‐effects in humans. We hypothesized that drug‐effects may be expressed differently depending on whether the rat is in active locomotion or sitting still during recording sessions, and proposed automatic state‐detection as a viable tool for estimating drug‐effects free of hypo‐/hyperlocomotion‐induced effects. We aimed at developing a fully automatic and validated method for detecting two behavioural states: active and inactive, in one‐second intervals and to use the method for evaluating ketamine, DOI, d‐cycloserine, d‐amphetamine, and diazepam effects specifically within each state. The developed state‐detector attained high precision with more than 90% of the detected time correctly classified, and multiple differences between the two detected states were discovered. Ketamine‐induced delta activity was found specifically related to locomotion. Ketamine and DOI suppressed theta and beta oscillations exclusively during inactivity. Characteristic gamma and high‐frequency oscillations (HFO) enhancements of the NMDAR and 5HT 2A modulators, speculated associated with locomotion, were profound and often largest during the inactive state. State‐specific analyses, theoretically eliminating biases from altered occurrence of locomotion, revealed only few effects of d‐amphetamine and diazepam. Overall, drug‐effects were most abundant in the inactive state. In conclusion, this new validated and automatic locomotion state‐detection method enables fast and reliable state‐specific analysis facilitating discovery of state‐dependent drug‐effects and control for altered occurrence of locomotion. This may ultimately lead to better cross‐species translation of electrophysiological effects of pharmacological modulations.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Hansen

Agerskov

Arvastson

et al. 2019

Eur J of Neuroscience

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“…While these data are correlative, they do suggest that NAcSh θ power might represent a trait-level 10 neural feature that relates to the sex differences observed in alcohol consumption. Previous studies have demonstrated that θ oscillations in the striatum, which are coherent with hippocampal rhythms, are implicated in working memory and attention tasks, and are inhibited by NAc dopamine receptor blockade (36)(37)(38). Along with the present study, these findings collectively suggest that NAc θ oscillations may be important in reward learning, and that low frequency NAcSh oscillations may perhaps serve as a potential therapeutic target in future research.…”

Section: Discussionsupporting

confidence: 85%

Sex differences in the ability of corticostriatal oscillations to predict rodent alcohol consumption

Henricks

Sullivan²,

Dwiel³

et al. 2019

Preprint

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Background: Although male and female rats differ in their patterns of alcohol use, little is known regarding the neural circuit activity that underlies these differences in behavior. The current study used a machine learning approach to characterize sex differences in local field potential (LFP) oscillations that may relate to sex differences in alcohol drinking behavior.Methods: LFP oscillations were recorded from the nucleus accumbens shell and the rodent medial prefrontal cortex of adult male and female Sprague-Dawley rats. Recordings occurred before rats were exposed to alcohol (n=10/sex X 2 recordings/rat) and during sessions of limited access to alcohol (n=5/sex X 5 recordings/rat). Oscillations were also recorded from each female rat in each phase of estrous prior to alcohol exposure. Using machine-learning, we built predictive models to classify rats based on: 1) biological sex; 2) phase of estrous; and 3) alcohol intake levels. We evaluated model performance from real data by comparing it to the performance of models built and tested on permutations of the data. Results:Our data demonstrate that corticostriatal oscillations were able to predict alcohol intake levels in males (p<0.01), but not in females (p=0.45). The accuracies of models predicting biological sex and phase of estrous were related to fluctuations observed in alcohol drinking levels; females in diestrus drank more alcohol than males (p=0.052), and the male vs. diestrus female model had the highest accuracy (71.01%) compared to chance estimates.Conversely, females in estrus drank similar amounts of alcohol to males (p=0.702), and the male vs. estrus female model had the lowest accuracy (56.14%) compared to chance estimates. Conclusions:The current data demonstrate that oscillations recorded from corticostriatal circuits contain significant information regarding alcohol drinking in males, but not alcohol drinking in females. Future work will focus on identifying where to record LFP oscillations in order to predict alcohol drinking in females, which may help elucidate sex-specific neural targets for future therapeutic development.

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“…However, recent studies question the potential influences of D2Rs on ketamine-induced abnormalities in the striatum [41]. Whether the dopaminergic and the glutamatergic systems function jointly or separately in striatum remains a key issue toward understanding the ability of both NMDARs and D2Rs modulators in inducing or reducing hallucinations.…”

Section: Confrontations Between Models and Attempts For Integrationmentioning

confidence: 99%

Pharmacology of Hallucinations: Several Mechanisms for One Single Symptom?

Rolland

Jardri

Amad

et al. 2014

BioMed Research International

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Hallucinations are complex misperceptions, that principally occur in schizophrenia or after intoxication induced by three main classes of drugs: psychostimulants, psychedelics, and dissociative anesthetics. There are at least three different pharmacological ways to induce hallucinations: (1) activation of dopamine D2 receptors (D2Rs) with psychostimulants, (2) activation of serotonin 5HT2A receptors (HT2ARs) with psychedelics, and (3) blockage of glutamate NMDA receptors (NMDARs) with dissociative anesthetics. In schizophrenia, the relative importance of NMDAR and D2R in the occurrence of hallucinations is still debated. Slight clinical differences are observed for each etiology. Thus, we investigated whether the concept of hallucination is homogenous, both clinically and neurobiologically. A narrative review of the literature is proposed to synthesize how the main contributors in the field have approached and tried to solve these outstanding questions. While some authors prefer one explanatory mechanism, others have proposed more integrated theories based on the different pharmacological psychosis models. In this review, such theories are discussed and faced with the clinical data. In addition, the nosological aspects of hallucinations and psychosis are addressed. We suggest that if there may be common neurobiological pathways between the different pharmacological systems that are responsible for the hallucinations, there may also be unique properties of each system, which explains the clinical differences observed.

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The effect of dopamine receptor blockade in the rodent nucleus accumbens on local field potential oscillations and motor activity in response to ketamine

Cited by 28 publications

References 46 publications

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Pharmaco‐electroencephalographic responses in the rat differ between active and inactive locomotor states

Sex differences in the ability of corticostriatal oscillations to predict rodent alcohol consumption

Pharmacology of Hallucinations: Several Mechanisms for One Single Symptom?

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