The Effect of Drug Pre-treatment on Taurine Transport at the Inner Blood-Retinal Barrier Under Variable Conditions

Gyawali, Asmita; Kang, Young‐Sook

doi:10.1007/978-981-13-8023-5_80

Cited by 4 publications

(1 citation statement)

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“…From the perspective of mechanism, the relationship between Pae and autophagy should be further studied in terms of mutated in multiple advanced cancers 1 induced putative kinase 1/Parkin‐dependent pathway and BNIP3L/Nix‐dependent pathway, so as to explain the protective mechanism of Pae on photosensitive neurons. Other studies have shown that it may act as an organic cationic substrate to inhibit taurine uptake in retinal cells of internal blood under high‐glucose environment, which contributes to the physiological homeostatin of retina (Gyawali & Kang, 2019). In addition, its effect on ICH neuronal iron death key protein HOTAIR should be involved in the study of iron death pathway.…”

Section: Discussion and Further Perspectivementioning

confidence: 99%

Protective mechanism of Paeonol on central nervous system

Wu,

Liu,

Zhang

et al. 2023

Phytotherapy Research

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Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists in many medicinal plants and has pharmacological effects such as anti‐atherosclerosis, antiplatelet aggregation, anti‐oxidation, and anti‐inflammatory, which keeps generally used in the treatment of cardiovascular and cerebrovascular diseases. Based on the therapeutic effects of Paeonol for cardiovascular and cerebrovascular diseases, this article reviewed the pharmacological effects of Paeonol in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, diabetes encephalopathy, and other neurological diseases, providing a reference for the research of the mechanism of Paeonol in central nervous system diseases.

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Section: Discussion and Further Perspectivementioning

confidence: 99%