The Effect of Endurance-Type Exercise Training on Growth Mediators and Inflammatory Cytokines in Pre-Pubertal and Early Pubertal Males

Scheett, Timothy P.; Nemet, Damir; Stoppani, James; Maresh, Carl M.; Newcomb, Robert L.; Cooper, Dan M.

doi:10.1203/00006450-200210000-00006

Cited by 70 publications

(37 citation statements)

References 36 publications

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“…For example, the reference value for IL-6 found in the recent edition of Nelson Textbook of Pediatrics (25) is 7 Ϯ 1 pg/mL, a value that is based on a paper by Krafte-Jacobs and Bock (26) who used 16 "outpatient and hospitalized children without infection or anemia." This reference value is higher than what we (27)(28)(29) and others (30) have consistently found in children, and probably reflects the fact that the children studied by Krafte-Jacobs and Bock, who are hospitalized or seen in an outpatient clinic, are likely to have increased circulating proinflammatory cytokines from stress, trauma, and other injuries, even in the absence of overt infection.…”

contrasting

confidence: 51%

Adipocytokines, Body Composition, and Fitness in Children

Nemet

2003

Pediatric Research

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contrasting

confidence: 51%

Adipocytokines, Body Composition, and Fitness in Children

Nemet

2003

Pediatric Research

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“…We found that two months of exercise training decreased circulatory IGF-1, when compared with the control group. This is in line with the results of previous studies (7,16,17,26). Evidence indicates that reduction of serum IGF-1 by lifestyle modification reduces the number of cancer cells, slows tumor progression and increases apoptosis in tumor cells (3, 7).…”

Section: Discussionsupporting

confidence: 92%

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats

2017

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Background and Objectives: We studied effects of eight weeks of resistance training and IGF-1 injection on serum level of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio in Wistar rats.Methods: We randomly divided 28 male Wistar rats into four groups of salineinjected control (C), resistance training+saline injection (RS), resistance training+IGF-1 injection (RI) and IGF-1 injection (II). Resistance training protocol consisted of climbing a ladder (three days/week with 5 reps/3 sets) while carrying a weight suspended from the tail for eight weeks. IGF-1 and saline (1.5 µg/kg/day) were injected before and after exercise sessions. Serum IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio and morphology of colorectal tissue were evaluated.Results: Serum IGF-1 level and IGF-1/IGFBP-3 ratio decreased in the RS group compared to the other groups (P< 0.05). Rats in the RS group had higher IGFBP-3 level than those in the II and RI groups (P< 0.05). IGF-1 injection had no effect on morphology of colorectal tissue. Conclusion:The resistance training reduces IGF-1 and increases IGFBP-3 levels, which might represent a link between resistance training and lower risk of colorectal cancer.

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“…In children, exercise training and aerobic power are associated with increases in circulating cytokines levels. 14,20 These authors did not present any information regarding the leukocyte populations, which is important since the leukocytes are one of the primary sites of cytokine production. Thus, the purpose of this study was to determine the effects of obesity and aerobic power on resting leukocyte profiles.…”

Section: Introductionmentioning

confidence: 99%

Body fat and circulating leukocytes in children

et al. 2006

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Objective: To determine the effects of obesity on baseline levels of circulating granulocytes, monocytes, and lymphocyte subtypes in otherwise healthy children. Design: Two group comparison of leukocytes in normal weight control and overweight children. Subjects: In total, 38 boys and girls, ages 6-18 years, divided in two groups: normal weight, (NW, BMIo85th %tile, n ¼ 15) and overweight (OW, body mass index (BMI)485th %tile, n ¼ 23). Measurements: BMI obtained from direct measures of height and body mass. Body fat was assessed by DEXA. Complete blood counts (CBC) were obtained by standard clinical hematology methods and surface antigen staining by flow cytometry. Results: The OW group compared to the NW group had increased total leukocytes counts (P ¼ 0.011), neutrophils (P ¼ 0.006), monocytes (P ¼ 0.008), total T (CD3) lymphocytes (P ¼ 0.022), and Helper T (CD4 þ ) cells (P ¼ 0.003). Significant correlations were evident between leukocytes, and BMI percentile, BMI, or percent body fat. Neither lean body mass nor VO 2peak per unit lean body mass were significantly related to any of the leukocytes. Percent body fat and BMI percentile were positively correlated (Po0.05) to total T cells (CD3) and/or helper T cells (CD4 þ ). Conclusion: A group of 23 overweight children displayed elevated counts in most types of circulating immune cells, suggesting the presence of low-grade systemic inflammation, a known pathogenetic mechanism underlying most long-term complications of obesity. Our data provide an additional rationale for the importance of avoiding or correcting pediatric obesity.

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The Effect of Endurance-Type Exercise Training on Growth Mediators and Inflammatory Cytokines in Pre-Pubertal and Early Pubertal Males

Cited by 70 publications

References 36 publications

Adipocytokines, Body Composition, and Fitness in Children

Adipocytokines, Body Composition, and Fitness in Children

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats

Body fat and circulating leukocytes in children

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