The Effect of Estradiol and Estriol on the Survival of Sublethally and Lethally Irradiated Mice

Thompson, John S.; Reilly, Richard W.; Crawford, Margaret K.; Russe, Henry P.

doi:10.2307/3571867

Cited by 12 publications

(5 citation statements)

References 18 publications

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“…Although E3 is believed to be absent in rodents (Turner & Bagnara, 1976) and has a much weaker effect on the reproductive organs than other compounds (Clark et al, 1977), E3 has been employed as a unique steroid that has a broad action on various other cells and tissues of rodents (Thompson et al, 1965;Kotani et al, 1979;Fujii et al, 1985). The present study demonstrated that the growth of receptor-negative KE-5 lymphoma cells was markedly pro- Time after tumour inoculation (days) Figure 6 The effect of hyaluronic acid on the incidence and onset of tumours in male mice.…”

Section: Discussionmentioning

confidence: 99%

“…Oestrogens induce an increase in the tissue contents of water and acid glycosaminoglycans, particularly hyaluronic acid in skin (AsboeHansen, 1963;Sobel et al, 1965;Bentley et al, 1986). Furthermore, the promoting effect of hyaluronic acid on tumour growth has been reported by many investigators, such as Takeuchi (1966) in Ehrlich ascites tumour cells and by Toole et al (1979) in rabbit V2 carcinoma.…”

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confidence: 99%

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Growth-promoting effect of oestriol in a lymphoma lacking oestrogen receptors

Kawatsu

Ezaki²,

Kotani³

et al. 1989

Br J Cancer

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Growth-promoting effect of oestriol in a lymphoma lacking oestrogen receptors

Kawatsu

Ezaki²,

Kotani³

et al. 1989

Br J Cancer

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“…As noted above, this is a period of rapiJ rise in lens flecks in the normal, and possibly of relatively high estrogen level. Experimental evidence pertaining to the influence of estrogen on radiolethality in the mouse 21 suggests the possibility that gonadal hormones may have been at least partly responsible for the difference in radiosensitivity between the sexes, and also for the difference in incidence between adolescence and maturity in the female. Such a mechanism might imply varying radiosensitivity in the female as a function of stage in the menstrual cycle or pregnancy at the time of irradiation.…”

Section: Discussionmentioning

confidence: 99%

Medical Survey of the People of Rongelap and Utirik Islands Thirteen, Fourteen, and Fifteen Years After Exposure to Fallout Radiation (March 1967, March 1968, and March 1969).

Conard¹,

Sutow²,

Lowrey³

1970

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This report was prepared as an account of Government sponsored work. Neither the United States, nor the Commission, nor any person acting on behalf of the Commission: A. Makes any warranty or representation, expressed or implied, with respect to the accuracy, completeness, or usefulness of the information contained in this report, or that the use cl any information, apparatus, method, or process disclosed in this report may not infringe privately owned rights; or B. Assumes any liabilities with respect to the use of, or for damages resulting from the use of any information, apparatus, method, or process disclosed in this report. As used in the above, "person acting on behalf of the Commission" includes any employee or contractor of the Commission, or employee of such contractor, to the extent that such employee or contractor of the Commission, or employee of such contractor prepares, disseminates, or provides access to, any information nursuant to his employment or contract with the Commission, or his employment with such contractor.

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“…As the first Food and Drug Administration (FDA)-approved clinical radioprotective agent, Amifostine has not been widely applied to clinical therapy to date for its heterogeneous efficacy [ 4 ]. The anti-radiation effects of estrogen have also been proven [ 5 ]. Nilestriol, one kind of estriol, showed antagonistic regulation against IR-induced RNAs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Human Pharmacokinetics of E0703, a Novel Radioprotective Agent, Using Physiologically Based Pharmacokinetic Modeling and an Interspecies Extrapolation Approach

Ge,

Zhang,

Yan

et al. 2024

IJMS

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E0703, a new steroidal compound optimized from estradiol, significantly increased cell proliferation and the survival rate of KM mice and beagles after ionizing radiation. In this study, we characterize its preclinical pharmacokinetics (PK) and predict its human PK using a physiologically based pharmacokinetic (PBPK) model. The preclinical PK of E0703 was studied in mice and Rhesus monkeys. Asian human clearance (CL) values for E0703 were predicted from various allometric methods. The human PK profiles of E0703 (30 mg) were predicted by the PBPK model in Gastro Plus software 9.8 (SimulationsPlus, Lancaster, CA, USA). Furthermore, tissue distribution and the human PK profiles of different administration dosages and forms were predicted. The 0.002 L/h of CL and 0.005 L of Vss in mice were calculated and optimized from observed PK data. The plasma exposure of E0703 was availably predicted by the CL using the simple allometry (SA) method. The plasma concentration–time profiles of other dosages (20 and 40 mg) and two oral administrations (30 mg) were well-fitted to the observed values. In addition, the PK profile of target organs for E0703 exhibited a higher peak concentration (Cmax) and AUC than plasma. The developed E0703-PBPK model, which is precisely applicable to multiple species, benefits from further clinical development to predict PK in humans.

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The Effect of Estradiol and Estriol on the Survival of Sublethally and Lethally Irradiated Mice

Cited by 12 publications

References 18 publications

Growth-promoting effect of oestriol in a lymphoma lacking oestrogen receptors

Growth-promoting effect of oestriol in a lymphoma lacking oestrogen receptors

Medical Survey of the People of Rongelap and Utirik Islands Thirteen, Fourteen, and Fifteen Years After Exposure to Fallout Radiation (March 1967, March 1968, and March 1969).

Prediction of Human Pharmacokinetics of E0703, a Novel Radioprotective Agent, Using Physiologically Based Pharmacokinetic Modeling and an Interspecies Extrapolation Approach

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