The effect of ethanol extract from Portulaca oleracea on inhibiting total cholesterol on animal subjects

Abstract

Introduction: Hypercholesterolemia occurs when cholesterol levels in the blood increases. Traditionally, krokot (purslane, portulaca oleracea) is used to treat cardiovascular disease. Aim: This research evaluated the effect of purslane extract to inhibit increasing of cholesterol levels. Methods: The ethanol extract dosage of purslane was 27.5, 55, and 110 mg/kg body weight (bw) and simvastatin 1.8 mg/kg bw were used as comparisons. The anti-hyper cholesterol effect test was done by feeding a high cholesterol diet and drinks containing 0.01% propylthiouracil. The test parameters were body weight and total cholesterol levels on days 0, 7, 14, and 21. Results: The results showed that the extract was able to prevent the increase in body weight compared to the control group (p<0.05) and that it could inhibit the increase of total cholesterol levels at day 14 and 21 compared to control group (p<0.05) and equivalent to simvastatin (p>0.05).

Vasodilatation Effects of Portulaca Oleracea L. Ethanol Extract on Animal Models

“…Antihypertensive mechanisms from plants include reducing peripheral resistance (vasodilators), decreasing body fluid volume (diuresis) or directly affecting the work of the heart [4,5]. One of the medicinal plants is Portulaca oleracea L. Pharmacologically, purslane is reported to have antioxidant, antibacterial, hepatoprotective, analgesic, anti-inflammatory, bronchodilator, antihyperglycemic, antihyperlipidemic, and anticancer activities [6,7]. Studies related to the use of purslane as an antihypertensive have been carried out starting with the induction method of epinephrine, dexamethasone and effects on smooth muscle [8][9][10] .…”