The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats

Jo, You Hwan; Kwon, Woon Yong; Lee, Jeong Hoon; Kim, Kyuseok; Shin, Sang Do; Kang, Young Joon; Suh, Gil Joon

doi:10.1080/15563650802304419

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…Pyruvate is an effective scavenger of the ROS, hydrogen peroxide, and hydroxyl radical [27][28][29]. EP is also an effective ROS scavenger, as evidenced by studies showing that EP inhibits hepatic lipid peroxidation induced by hemorrhagic shock in rats [12], methemoglobin formation induced by dapsone ingestion in rats [30], testicular lipid peroxidation in rats subjected to testicular I/R injury [31], and ileal lipid peroxidation in rats subjected to cutaneous burn injury [6]. In the present study, all four compounds studied, namely pyruvate, EP, BF, and PHPP, ameliorated hepatic lipid peroxidation induced by transient aortic occlusion.…”

Section: Discussionmentioning

confidence: 94%

Effects of Ethyl Pyruvate and Other α-Keto Carboxylic Acid Derivatives in a Rat Model of Multivisceral Ischemia and Reperfusion

Cruz

Harada

Sasatomi

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 94%

Effects of Ethyl Pyruvate and Other α-Keto Carboxylic Acid Derivatives in a Rat Model of Multivisceral Ischemia and Reperfusion

Cruz

Harada

Sasatomi

et al. 2011

Journal of Surgical Research

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“…Moreover, it has been reported that antioxidants can prevent the progress of pulmonary fibrosis (Suntres, 2002;Jo et al, 2008). The commonly used drugs include vitamin C, vitamin E, ambroxol, glutathione, and n-acetylcysteine (Moon and Chun, 2011).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of patients with paraquat intoxication: three case reports and review of the literature

Zhang

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. Methods: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g). Results: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exudation, and both lungs clear of auscultation. Conclusions: The protective effect of the lungs may have been due to timely treatment at adequate doses.

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“…34 Notably, the beneficial effects of 100 mg/kg ethyl pyruvate were superior compared to those of 50 mg/kg, which are consistent with our dose-response results ( Figure S1). A single intraperitoneal dose of ethyl pyruvate was able to reduce methaemoglobinaemia induced by dapsone for a short period of time of 3-6 h. 56 Thus, a second dose was designed to be given after the mice subjected to 4 hours of MV at our protocol. As for the toxicity of ethyl pyruvate, dosage up to 150 mg/kg was proven to be a safe and effective medication in endotoxaemic horses, and ethyl pyruvate (90 mg/kg) at 6-hour intervals for five more doses was used with safety in human trials.…”

Section: Discussionmentioning

confidence: 99%

Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high‐mobility group box‐1 in a murine endotoxaemia model

Liu

Chen

Chang

et al. 2019

J Cellular Molecular Medi

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Mechanical ventilation (MV) can save the lives of patients with sepsis. However, MV in both animal and human studies has resulted in ventilator‐induced diaphragm dysfunction (VIDD). Sepsis may promote skeletal muscle atrophy in critically ill patients. Elevated high‐mobility group box‐1 (HMGB1) levels are associated with patients requiring long‐term MV. Ethyl pyruvate (EP) has been demonstrated to lengthen survival in patients with severe sepsis. We hypothesized that the administration of HMGB1 inhibitor EP or anti‐HMGB1 antibody could attenuate sepsis‐exacerbated VIDD by repressing HMGB1 signalling. Male C57BL/6 mice with or without endotoxaemia were exposed to MV (10 mL/kg) for 8 hours after administrating either 100 mg/kg of EP or 100 mg/kg of anti‐HMGB1 antibody. Mice exposed to MV with endotoxaemia experienced augmented VIDD, as indicated by elevated proteolytic, apoptotic and autophagic parameters. Additionally, disarrayed myofibrils and disrupted mitochondrial ultrastructures, as well as increased HMGB1 mRNA and protein expression, and plasminogen activator inhibitor‐1 protein, oxidative stress, autophagosomes and myonuclear apoptosis were also observed. However, MV suppressed mitochondrial cytochrome C and diaphragm contractility in mice with endotoxaemia ( P < 0.05). These deleterious effects were alleviated by pharmacologic inhibition with EP or anti‐HMGB1 antibody ( P < 0.05). Our data suggest that EP attenuates endotoxin‐enhanced VIDD by inhibiting HMGB1 signalling pathway.

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The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats

Abstract: A single intraperitoneal dose of EP was able to reduce methemoglobinemia induced by dapsone for a short period of time, but this effect was not sustained.

Cited by 6 publications

References 30 publications

Effects of Ethyl Pyruvate and Other α-Keto Carboxylic Acid Derivatives in a Rat Model of Multivisceral Ischemia and Reperfusion

Effects of Ethyl Pyruvate and Other α-Keto Carboxylic Acid Derivatives in a Rat Model of Multivisceral Ischemia and Reperfusion

Successful treatment of patients with paraquat intoxication: three case reports and review of the literature

Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high‐mobility group box‐1 in a murine endotoxaemia model

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