The effect of etodolac on type II collagen-induced arthritis in mice

Abstract

Type II collagen-induced arthritis (CIA) and mice was used as a model to evaluate the effect of etodolac on the arthritic and immunological parameters of the experimental disease. In a preventative protocol, a significant reduction was observed in the number of joints progressing to ankylosis. At high doses (16 mg/kg/day) a significant delay in the onset of arthritis was also observed. No significant effect was seen on the progression of the disease when etodolac was administered in established CIA. No consistent variations were observed in the anti-type II collagen response or other immunological parameters of the experimental arthritis.

Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions

“…Indomethacin slightly reduced the development of periarticular damage, which was not significantly affected by etodolac. These present results support previous studies demonstrating the anti-arthritic efficacy of etodolac in animal models [3,5]. In rats with adjuvant arthritis [3], etodolac reduced the development of bone damage, while aspirin and naproxen did not.…”

“…In rats with adjuvant arthritis [3], etodolac reduced the development of bone damage, while aspirin and naproxen did not. It has also been reported that etodolac significantly decreased the number of ankylosed joints in mice with type II collagen arthritis [5]. These joints had been reported to be insensitive to nonsteroidal anti-inflammatory drugs, such as aspirin, naproxen, and benoxaprofen…”

“…The anti-arthritic activity of etodolac has been shown in animal models of experimentally-induced arthritis, such as adjuvant arthritis in rats, and type II collagen arthritis in mice [3][4][5]. These reports also showed that etodolac inhibits the development of bone destruction in experimentally-induced arthritis.…”

“…Etodolac, a new nonsteroidal anti-inflammatory drug, has analgesic, anti-inflammatory, and antiarthritic properties [1][2][3][4][5]. The anti-arthritic activity of etodolac has been shown in animal models of experimentally-induced arthritis, such as adjuvant arthritis in rats, and type II collagen arthritis in mice [3][4][5].…”

The effect of etodolac on experimental temporomandibular joint osteoarthritis in dogs

“…It has been reported that etodolac can improve the function of osteoarthritic joints in canines (Johnston and Budsberg, 1997;Budsberg et al, 1999). Etodolac suppresses osteoarthritis induced experimentally in limbs of mice (Wooley et al, 1987). High doses of etodolac are more effective than lower doses (Inoue et al, 1993).…”