The effect of excessive iron intake upon the health and production of dairy cows

Coup, M. R.; Campbell, A. G.

doi:10.1080/00288233.1964.10416390

Cited by 33 publications

(18 citation statements)

References 6 publications

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“…The NRC (2001) assigns an absorption coefficient of 0.10 to dietary Fe, with a maximum recommendation of 1,000 mg/kg of DM. Cows grazing pasture irrigated with high-Fe water (17 mg/L) had reduced milk yield and their feces were dark, frothy, and malodorous (Coup and Campbell, 1964). Cows grazing pasture irrigated with high-Fe water had greater BW loss than cows grazing pastures not irrigated by high Fe water.…”

Section: Introductionmentioning

confidence: 99%

“…Excess iron available in the intestinal tract can interfere with absorption of other minerals and may cause oxidative stress, bacterial infection, diarrhea, and reduced weight gain (Coup and Campbell, 1964;Standish et al, 1971;Bullen et al, 1978;McGuire et al, 1985;Hansen et al, 2010). Genther and Beede (2013) reported lower water intake in lactating cows abomasally infused with ferrous lactate equivalent to 8 mg of Fe/L of drinking water.…”

Section: Introductionmentioning

confidence: 99%

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Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows

Feng

Knowlton

Dietrich

et al. 2013

Journal of Dairy Science

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The objective of this study was to evaluate the effect of ferrous lactate infusion on postruminal P absorption in lactating dairy cows. Four ruminally cannulated lactating cows were used in a 4×4 Latin square design with 14 d per period. Cows were fed a basal diet containing 0.39% P, providing 100% of the calculated P requirement. On d 8 to 14 of each period, each cow was infused with 0, 200, 500, or 1,250mg of Fe/d in the form of ferrous lactate solution (ferrous lactate in 1L of double-distilled water) into the abomasum. Infusate was formulated to approximate 0, 2, 5, or 12.5mg of Fe/L in drinking water with 100L of water intake/d. Total fecal collection was conducted in the last 4 d of each period to measure nutrient digestion and excretion. Dry matter intake, milk yield, and milk composition were not affected by treatment. Digestibility of DM, NDF, and nitrogen decreased linearly with increasing ferrous lactate infusion. Infusion of ferrous lactate did not affect intake and digestibility of total P, inorganic P, or phytate P. In lactating cows, P absorption was not negatively influenced by abomasally infused ferrous lactate up to 1,250mg of Fe/d.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows

Feng

Knowlton

Dietrich

et al. 2013

Journal of Dairy Science

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“…Although there is little convincing evidence that dietary Fe deficiency ever occurs in ruminants grazing pasture (Underwood, 1977), ruminants grazing pasture or being fed harvested silage or hay frequently may be exposed to excessive levels of Fe through forage, water or soil ingestion (Coup and Campbell, 1964;Campbell et al, 1974;Humphries et al, 1983). Excess dietary Fe can affect performance adversely in ruminants (Coup and Campbell, 1964;Standish et al, 1969;Koong et al, 1970;. High dietary Fe can affect utilization of other minerals such as Cu, P, Zn and Mn (Standish et al, 1969Campbell et al, 1974;Humphries et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Iron on Performance and Mineral Utilization in Lambs Fed a Forage-Based Diet

Prabowo

Spears

Goode

1988

Journal of Animal Science

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Twenty-four lambs, averaging 29 kg, were used to determine the effect of supplemental dietary Fe on performance and Cu, P, Zn and Mn utilization. Treatments consisted of supplemental Fe at 0, 300, 600 or 1,200 mg/kg diet as ferrous carbonate. The basal diet contained 154 mg Fe/kg diet and consisted of 90% Coastal bermudagrass pellets, 9.45% group corn, .5% sodium chloride and .05% vitamin mix. Lambs were slaughtered after having ad libitum access to diets for 98 to 121 d. Dietary Fe did not affect lamb gain or feed intake. Supplemental Fe increased Fe concentrations in liver (P less than .01), spleen (P less than .01) and bone (P less than .10), but not in kidney and muscle. Serum Fe concentrations and percentage transferrin saturation in serum were increased (P less than .01) by supplemental Fe at 28 and 84 d, but not at the termination of the study. Plasma Cu was decreased (P less than .01) at 56 d, whereas serum ceruloplasmin activity was reduced (P less than .01) at 28 d in lambs fed 1,200 mg Fe/kg diet compared with lambs fed 600 mg Fe/kg diet. Lower levels of Fe (300 and 600) reduced (P less than .01) ceruloplasmin by 56 d and plasma Cu by 84 d compared with controls. Liver Cu also was decreased (P less than .05) by supplemental Fe. Plasma P was decreased slightly (P less than .10) by 28 d and significantly (P less than .01) at the other sampling dates by supplemental Fe.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Therefore, the remaining dietary supplements that reduce the dietary Cu bioavailability are Mo, S, Zn and Fe (Dick, 1954;Ross, 1966 and1970;Hogan et al, 1968;Suttle, 1974 and1975;Bremner et al, 1976;Phillipo et al, 1987). Owing to the fact that the concentration of Fe in PKC is known to range between 800 and 6000 mg/kg DM and was 1512 mg/kg DM in the presently used PKC, and that the excessive dietary concentrations of Fe may result in bent legs of lambs (Hidiroglou et al, 1978) and in decreased productivity in dairy cows (Coup and Campbell, 1964), the use of dietary Fe to reduce the bioavailability of dietary Cu was not considered in the present experiment. It should be pointed out that even though the Fe content in PKC is extremely high, the chronic Cu toxicity in Malaysia in sheep fed diets containing a high proportion of PKC (over 30%) persists and the dietary supplementation with S was not effective in reducing the hepatic Cu accumulation (Alimon et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary molybdenum, sulfur and zinc on the excretion and tissue accumulation of trace elements in sheep fed palm kernel cake-based diets

Al-Kirshi

Alimon

Ivan

2011

Animal

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Twelve male 8-month-old lambs were used in a 6-month feeding experiment to determine the effects of dietary Mo, Mo 1 S and Zn supplements on the body retention and tissue accumulation of dietary Cu, Zn and Fe. The lambs were divided into four groups of three lambs each and each group was fed ad libitum one of four diets. A control diet was based on palm kernel cake (PKC) and grass hay. Three additional diets were the control supplemented with either Mo or Mo 1 S or Zn. At 3 months of the experiment, feces and urine were collected and sampled for 6 days. At the end of the experiment (6 months), blood was sampled and then the sheep were slaughtered. The liver and kidney were removed and sampled for chemical analysis. In comparison with the control, each dietary supplement decreased (P , 0.05) the Cu concentration in the liver, but only the Mo 1 S supplement decreased it to a safe range of below 350 mg/g dry matter. This was accompanied by the body retention of dietary Cu of 24.6%, 6.7%, 2.5% and 6.5% for the control, Mo, Mo 1 S and Zn treatments, respectively. The blood plasma concentration of Cu was decreased (P , 0.05) by the Zn supplement, but was not affected by other supplements (P . 0.05). It was concluded that from the supplements tested, only Mo 1 S appeared to be effective in reducing the retention and liver accumulation of the dietary Cu to prevent chronic Cu toxicity in sheep fed PKC-based diets.

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The effect of excessive iron intake upon the health and production of dairy cows

Cited by 33 publications

References 6 publications

Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows

Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows

Effects of Dietary Iron on Performance and Mineral Utilization in Lambs Fed a Forage-Based Diet

Effects of dietary molybdenum, sulfur and zinc on the excretion and tissue accumulation of trace elements in sheep fed palm kernel cake-based diets

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