The effect of exchange transfusion on prooxidant-antioxidant balance in newborns Jaundice

Boskabadi, Hassan; Mollaei, Maryam Kalate; Zakerihamidi, Maryam; Mobarhan, Majid Ghayour; Bagheri, Fariborz

doi:10.15419/bmrat.v5i3.425

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…In confirmation of the previous study, another research demonstrated that as an infant's bilirubin level decreases with phototherapy the balance of oxidant-antioxidant is disrupted toward antioxidant depletion (9). Results of the other investigation likewise showed that blood exchange causes an oxidantantioxidant imbalance in favor of the oxidants (12). It should be noted that regardless of the anti-oxidative role of the bilirubin, pathologic level of bilirubin has its formerly proven neurotoxicity.…”

Section: Discussionsupporting

confidence: 60%

“…In a study, PAB level in infants with jaundice who needed treatment was reported 16 HK (9). In another research, PAB level in infants with jaundice who needed blood exchange was reported 19.06 HK (12). The median PAB level in infants with physiologic jaundice was 38.27 HK.…”

Section: Discussionmentioning

confidence: 92%

“…The most common and effective treatment for jaundice is phototherapy which is known to be a safe and tolerable method in infants (10). However, in recent decades phototherapy has been determined as an oxidative agent that can cause peroxidation of lipids and damage to the DNA (11)(12)(13). Traditional phototherapy has a negative effect on the oxidant-antioxidant defense system in infants born at term (13).…”

Section: Introductionmentioning

confidence: 99%

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The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

et al. 2020

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Background: Jaundice can be observed in two-thirds of infants. Bilirubin prevents damage to the DNA from the oxidative stress of reactive oxygen species (ROS). Moreover, bilirubin has anti-inflammatory and anti-apoptotic roles in addition to antioxidant properties. Objectives: We decided to compare pro-oxidant-antioxidant balance (PAB) in physiologic and pathologic jaundice. Methods: This cross-sectional study evaluated 171 infants more than 35 weeks of gestational and > 2 days of postnatal age who were admitted to the Ghaem Hospital with jaundice from 2017 to 2019. Infants with bilirubin levels less or equal to 14 mg/dL on the jaundice meter were put in the physiologic jaundice group and infants with bilirubin higher than 15 mg/dL on the jaundice meter were entered into the study as the pathologic jaundice group. A questionnaire containing data regarding neonate's characteristics and the mother's medical history was filled out for each infant. Bilirubin levels, hematocrit, direct and or indirect Combs, reticulocytes, and PAB were evaluated in the case group. Results: The average age of the enrolled neonates was 7.3 ± 4.11 days and 52.4% of them were male. Between two groups of physiologic and pathologic jaundice, gestational age (P = 0.010), parity (P = 0.001) and PAB (P = 0.000) were significantly different. Overall, the amounts of the mentioned parameters in the pathologic jaundice group were less than the physiologic jaundice group. Conclusions: A pathological increase in bilirubin levels irrespective of its neurotoxic properties can change the pro-oxidantantioxidant balance in favor of antioxidants. It seems that neurotoxic mechanism of bilirubin in pathological amounts differ with its antioxidant effects.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

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“…The findings of a study comparing PAB levels in neonates with and without asphyxia indicated mean PAB levels were 20 and 40 HK in healthy neonates and neonates with asphyxia, respectively ( 5 ). In two other studies, the mean PAB of neonates was reported to be about 40 HK after jaundice recovery ( 25 , 26 ). A study investigated the effects of selenium consumption, critical to the function of some anti-oxidant enzymes, during pregnancy on the PAB levels of neonates.…”

Section: Discussionmentioning

confidence: 88%

Comparing maternal and neonatal prooxidant-antioxidant balance during delivery

Boskabadi¹,

Maamouri²,

Ayati³

et al. 2023

J Turkish German Gynecol Assoc

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Objective: Oxidative stress (OS) is due to a disturbance in the balance between the production of free radicals and antioxidant defense, resulting in a predominance of free radicals over endogenous anti-oxidant defenses. OS may have many causes. Pregnancy, and especially delivery, are associated with increased OS. The relationship between maternal and infant prooxidant-antioxidant balance (PAB) is unclear. Therefore, the aim of the present study was to compare PAB in mother and baby pairs. Material and Methods: This cross-sectional study was conducted in 104 mothers and normal term infants during 2017-2020. PAB was measured in healthy mothers before delivery and in umbilical cord samples after delivery. Data on the infant characteristics including age, gestational age, birth weight, Apgar score, and maternal history including the duration of mother’s education, weight of the last month, and gravidity were collected using a researcher-made questionnaire. The cord and maternal PAB were compared by statistical methods. Results: In this study, the mean PAB of the neonates and mothers was 30.76 and 214.87 HK, respectively. The results revealed a moderate association between the PAB neonate and maternal PAB before delivery but it was not significant. Conclusion: Overall, the level of oxidants and antioxidants reduced during pregnancy and before delivery, and it was found that the relative incidence of neonatal PAB increases by increasing maternal PAB.

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“…This limited capacity is even more serious in preterm neonates and those with low birth weight. Oxidative damage plays an important role in the pathogenesis of many neonatal diseases [12,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of phototherapy on pro-oxidant/antioxidant balance in newborns with Jaundice

2018

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Introduction: Jaundice is the most common condition requiring medical attention in newborns. Phototherapy is the standard treatment for jaundice. However, in recent decades, phototherapy has been considered as an oxidative stress that can cause lipid peroxidation and damage to DNA. Accordingly, the present study was conducted to examine the possible effects of phototherapy on the Pro-oxidant/Antioxidant Balance (PAB) in jaundiced newborns. Methods: The present clinical trial was conducted on 70 icteric term neonates admitted to Ghaem Hospital of Mashhad, Iran between February 2013 and February 2015. The study population consisted of all term neonates who were admitted to the hospital within 2 to 14 days after birth for unconjugated hyperbilirubinemia (bilirubin levels > 15 mg/dl) and were treated with phototherapy. Neonates’ and mothers’ characteristics, along with the cause of jaundice, were collected through a researcher-made questionnaire, and neonates’ bilirubin levels and PAB values were simultaneously checked before, during and after the phototherapy. Finally, bilirubin levels and PAB values were compared using statistical methods. Results: According to the results, neonates’ underlying characteristics were not statistically different. The average and standard deviation of bilirubin levels and PAB values were, respectively, 18.90±2.97 and 16.29±9.83 (before phototherapy), 15.71±3.16 and 29.63±12.56 (during phototherapy), and 12.37 ±3.57 and 40.91 ±13.35 (after phototherapy). Conclusion: The results of this study demonstrate that decreased levels of bilirubin after phototherapy cause a shift in the PAB value in favor of oxidants.

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The effect of exchange transfusion on prooxidant-antioxidant balance in newborns Jaundice

Cited by 6 publications

References 19 publications

The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

Comparing maternal and neonatal prooxidant-antioxidant balance during delivery

Effect of phototherapy on pro-oxidant/antioxidant balance in newborns with Jaundice

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