The Effect of Exercise on Circulating Immunoreactive Calcitonin in Men

O'Neill, M E; Wilkinson, M. C.; Robinson, Bruce G.; McDowall, D.; Cooper, Kumarasen; Mihailidou, Anastasia S.; Frewin, D. B.; Clifton-Bligh, P; Hunyor, Stephen N.

doi:10.1055/s-2007-1004968

Cited by 14 publications

(3 citation statements)

References 13 publications

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“…Henderson et al (1989), using a corrective formula, showed that even when pH eects are controlled, a signi®cant rise in plasma Ca 2+ occurs. The same conclusion has been drawn after correction for haemoconcentration (O'Neill et al 1990). The results of animal studies lend support to the hypothesis that the main source of plasma Ca 2+ during exercise is bone, which is the most important Ca 2+ store (Ruben and Bennet 1981).…”

Section: Discussionsupporting

confidence: 71%

Moderate endurance training has no effect on the parathyroid function of heart transplant patients

Charloux

Brandenberger²,

Lampert

et al. 1997

European Journal of Applied Physiology

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The benefit of retraining for heart transplant recipients (HTR) is now well established. The rehabilitation of these patients can be compromised by osteopenia and bone fractures. The resting levels of parathyroid hormone (PTH) and exercise-induced increases are higher in HTR than in healthy controls. To evaluate the effect of a moderate endurance training programme on parathyroid activity, six HTR, an average of 18 months after transplant, and seven healthy sedentary controls have been studied. None of the subjects had a history of bone disease. Two exercise tests (square wave endurance exercise tests, SWEET) with identical work rates were performed before and after training. Intact PTH, ionized calcium (Ca2+), phosphorus (Pi) and pH were measured at rest, during exercise and in the recovery periods. Training consisted of a 45-min SWEET three times a week for 6 weeks. Levels of Ca2+, Pi and PTH showed a significant increase during the exercise session in both groups. Ca2+ and Pi levels decreased rapidly after the cessation of exercise whereas PTH reached a peak at the 10th min of the recovery in both groups. This increase in PTH was significantly higher in HTR than in controls. However, despite a significant improvement of total endurance work (+ 28% in HTR, +29% in controls) this endurance training had no effect on resting levels of PTH, plasma Ca2+ or Pi, nor on their exercise-induced variations. The exercise-induced decrease in pH was less pronounced after training which is evidence of training. We conclude that a short endurance training programme does not alter the moderate hyperparathyroidism of HTR. The effect of such a training programme on bone mass and bone mineral density needs now to be evaluated.

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Section: Discussionsupporting

confidence: 71%

Moderate endurance training has no effect on the parathyroid function of heart transplant patients

Charloux

Brandenberger²,

Lampert

et al. 1997

European Journal of Applied Physiology

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“…Short and moderate duration (minutes to hours) exercises have demonstrated elevated or unchanged values of calcitonin associated with both elevated and decreased serum calcium (Nishiyama et al, 1988;O'Neill et al, 1990, Cunningham et al, 1985. A moderate and temporary increase in PTH might enhance bone formation (Parfitt 1976;McDonald et al, 1986;Reeve et al, 1990) in line with the observed systemic effects of exercise.…”

Section: Discussionmentioning

confidence: 97%

Acute Effects of ChunDoSunBup Qi-training on Blood Concentrations of TSH, Calcitonin, PTH and Thyroid Hormones in Elderly Subjects

et al. 1998

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The present study investigated how the systemic treatment of a programmed exercise, ChunDoSunBup (CDSB) Qi-training, affects the secretion of thyroid and parathyroid hormones in elderly subjects (10 male and 5 female). Plasma concentrations of thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), parathyroid hormone (PTH), ionized calcium, and calcitonin were determined. CDSB Qi-training induces a slight increase in TSH. Both T4 and T3 were increased at the mid-time of CDSB Qi-training (p < 0.05). There were significant correlations only between T3 and T4 at mid-training. This shows that increase in the plasma level of T3 was associated with the secretion of T4. The plasma concentrations of calcitonin and PTH were increased at mid-time and post-time of CDSB Qi-training. But ionized calcium was decreased slightly by CDSB Qi-training. These results suggest that Qi-training modulates the secretion of thyroid hormones, calcium metabolism, and parathyroid hormones in the elderly. However, whether the long-term practice of CDSB Qi-training might change bone metabolism and have longitudinal effects on the thyroid hormone of the elderly need further investigation.

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“…Calcitonin levels increased [ 107 , 108 ] or did not change [ 20 , 109 , 110 , 111 , 112 ] during exercise. However, these results should be verified in larger cohorts as most of these studies involved less than 30 participants ( Table 2 ).…”

Section: Environmental Factors That Affect Pth and Calcitonin Levelsmentioning

confidence: 99%

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Leko

Pleić

Gunjača

et al. 2021

IJMS

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Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.

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The Effect of Exercise on Circulating Immunoreactive Calcitonin in Men

Cited by 14 publications

References 13 publications

Moderate endurance training has no effect on the parathyroid function of heart transplant patients

Moderate endurance training has no effect on the parathyroid function of heart transplant patients

Acute Effects of ChunDoSunBup Qi-training on Blood Concentrations of TSH, Calcitonin, PTH and Thyroid Hormones in Elderly Subjects

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

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