The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy: a systematic review and meta-analysis

Bigaran, Ashley; Zopf, Eva M.; Gardner, Jason R; Gerche, André La; Murphy, Declan; Howden, Erin J.; Baker, Michael K.; Cormie, Prue

doi:10.1038/s41391-020-00273-5

Cited by 27 publications

(47 citation statements)

References 49 publications

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“…Studies conducted in PCa patients have shown that ET is an important strategy that can be used to mitigate PCa-related clinical features, such as lower circulating glucose and insulin levels, increased adipose tissue mass, and whole-body inflammatory markers as well as improving hormonal levels [ 15 , 16 , 108 ]. Furthermore, the impact of ET in skeletal muscle was observed by inducing phenotypic alterations mediated by transcriptional responses that occur during and following an exercise session [ 7 ].…”

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

“…Furthermore, the benefits of ET extend to other aging-related comorbidities or cancer treatments side effects. For example, patients with PCa exposed to ADT were shown to have an increased risk for developing cardiovascular disease, which could be attenuated by regular ET [ 16 ].…”

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

“…A greater skeletal muscle mass may assist in improving cancer-related outcomes [ 161 ]. Indeed, ET has been largely used as an adjunct therapy for PCa patients [ 16 ], even though the isolated effects of ET are not completely understood [ 162 ].…”

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

“…A loss of skeletal muscle mass and strength apparently impacts cancer survival, not only through physiologic and metabolic-related mechanisms, but also through behavioral aspects, e.g., reduced physical activity levels due to deconditioning and fatigue imposed by cancer treatments [ 14 ]. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT that likely result in protective effects on metabolic and inflammatory features that typically characterize obesity and cancer diseases [ 5 , 7 , 15 , 16 ]. Moreover, ET promotes the synthesis and secretion of several factors known as myokines (when released by skeletal muscle) or adipokines (when released by WAT).…”

Section: Introductionmentioning

confidence: 99%

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Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Rocha-Rodrigues

Matos

Afonso

et al. 2021

IJMS

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Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these effects are mediated by ET-induced synthesis and secretion of several proteins, known as myo- and adipokines. Together, myokines and adipokines may act in an endocrine-like manner to favor communication between skeletal muscle and WAT, as they may work together to improve whole-body metabolic health. This crosstalk may constitute a potential mechanism by which ET exerts its beneficial role in the prevention and treatment of PCa-related disorders; however, this has not yet been explored. Therefore, we reviewed the current evidence on the effects of skeletal muscle–WAT–tumor crosstalk in PCa, and the potential mediators of this process to provide a better understanding of underlying ET-related mechanisms in cancer.

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Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

Section: Exercise Training As An Intervention For Obesity and Prostate Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Rocha-Rodrigues

Matos

Afonso

et al. 2021

IJMS

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“…Some of these adverse effects may be preventable or reversible with exercise [ 7 , 8 ], which is increasingly recognised by healthcare providers and patients. Moreover, exercise has been found to improve patient-reported outcomes (PRO) such as QoL and fatigue [ 7 , 9 , 10 ] but also physiological outcomes such as cardiovascular fitness, muscle strength, and endurance [ 7 , 8 , 11 , 12 ] in men diagnosed with prostate cancer. Additionally, general physical activity has been associated with reduced overall and prostate cancer-specific mortality [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis

Andersen

Midtgaard

Bjerre

2022

IJERPH

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Men diagnosed and treated for prostate cancer experience severe adverse effects on quality of life (QoL) and metabolic health, some of which may be preventable or reversible with exercise, the benefits of which healthcare providers and patients increasingly acknowledge, though existing evidence on its effects varies in significance and magnitude. We aimed to review the effect of exercise on QoL and metabolic health in a broad prostate cancer population. A systematic search was conducted in nine databases and eligible trials were included in the meta-analytic procedure. All outcomes were stratified into aerobic exercise, resistance exercise, and a combination of both. The review identified 33 randomised controlled trials (2567 participants) eligible for inclusion. Exercise had a borderline small positive effect on cancer-specific QoL (standardised mean difference (SMD) = 0.10, 95% confidence interval (CI) −0.01–0.22), and a moderate to large effect on cardiovascular fitness (SMD = 0.46, 95% CI 0.34–0.59) with aerobic exercise being the superior modality (SMD = 0.60, 95% CI 0.29–0.90). A positive significant effect was seen in lower body strength, whole-body fat mass, general mental health, and blood pressure. No significant effect was seen in fatigue, lean body mass, and general physical health. We thereby conclude that exercise is effective in improving metabolic health in men diagnosed with prostate cancer, with aerobic exercise as the superior modality. The effect of exercise on QoL was small and not mediated by choice of exercise modality.

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Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy

Papadopoulos

Leach

Tomlinson

et al. 2022

Support Care Cancer

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The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy: a systematic review and meta-analysis

Cited by 27 publications

References 49 publications

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer

Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis

Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy

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