The effect of exogenous oxytocin on estrous cycle length and corpus luteum lysis in ewes

Hatjiminaoglou, I.; Alifakiotis, T.; Zervas, N. P.

doi:10.1051/rnd:19790304

Cited by 17 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…oxytocin twice a day on Days 2-6) indicate that CL weight was also unaffected. The absence of luteolytic effects of oxytocin in our study are in contrast to the results reported by Hatjiminaoglou et al (1979) that oxytocin injected twice a day during the first week after oestrus resulted in decreased luteal weight and progesterone concentration. Milne ( 1963) reported histological indications of degeneration of ovine CL after oxytocin treatment early in the oestrous cycle.…”

Section: Discussioncontrasting

confidence: 86%

Function and lifespan of corpora lutea in ewes treated with exogenous oxytocin

Milvae

Duby²,

Tritschler³

et al. 1991

Reproduction

View full text Add to dashboard Cite

Oxytocin was administered to Dorset and Shropshire ewes in one experiment and to Dorset ewes in a further 4 experiments. In Exp. 1, concentrations of plasma progesterone and lengths of the oestrous cycle in ewes given oxytocin subcutaneously twice a day on Days 0-3, 2-5, 4-7, 6-9, 8-11, 10-13, 12-15 or 14-17 were similar to those of control ewes. In Exp. 2, intraluteal infusions of oxytocin from Day 2 to Day 9 after oestrus had no effect on concentration of progesterone, weight of CL collected on Day 9 or length of the oestrous cycle. In Exp. 3, intraluteal infusions of oxytocin on Days 10-15 after oestrus had no effect on weight of CL collected on Day 15. In Exp. 4, s.c. injections of oxytocin on Days 3-6 after oestrus had no effect on weight of CL collected on Day 9, concentrations of progesterone or length of the oestrous cycle. In Exp. 5, s.c. injections of oxytocin twice a day did not affect the maintenance and outcome of pregnancy in lactating and nonlactating ewes. Exogenous oxytocin, therefore, does not appear to affect luteal function at any stage of the ovine oestrous cycle although oxytocin has been reported by others to alter ovine CL function.

show abstract

Section: Discussioncontrasting

confidence: 86%

Function and lifespan of corpora lutea in ewes treated with exogenous oxytocin

Milvae

Duby²,

Tritschler³

et al. 1991

Reproduction

View full text Add to dashboard Cite

show abstract

“…Exogenously administered OT has, however, been shown to induce some degree of luteal regression or insufficiency in several ruminants (222)(223)(224)(225)(226)(227)(228), a process requiring the presence of the uterus (229,230). Although these effects were originally considered pharmacological, several new studies suggest that OT may have a physiological role during luteolysis in ruminants.…”

Section: Oxytocin (Ot) and Luteolysis: Sheep And Cowsmentioning

confidence: 95%

Mechanisms Controlling Corpus Luteum Function in Sheep, Cows, Nonhuman Primates, and Women Especially in Relation to the Time of Luteolysis

Auletta

Flint²

1988

Endocrine Reviews

164

View full text Add to dashboard Cite

“…Oxytocin administered early in the luteal phase of the oestrous cycle causes luteolysis in cattle (Armstrong & Hansel, 1959) and goats (Cooke & Knifton, 1981), and some degree of luteal regression in sheep (Milne, 1963;Dobrowolski, 1973;Hatjiminaglou, Alifakiotis & Zervas, 1979), probably through a stimulatory effect on uterine prostaglandin (PG) F-2a secretion (Hansel & Wagner, 1960;Sharma & Fitzpatrick, 1974;Mitchell, Flint & Turnbull, 1975;Roberts, McCracken, Gavagan & Soloff, 1976). Episodes of secretion of PGF-2a occur simultaneously with those of oxytocin (Flint & Sheldrick, 1983) or oxytocin neurophysin (Fairclough et al, 1980) at luteal regression and both active and passive immunization against oxytocin lead to a delay in luteolysis (Sheldrick, Mitchell & Flint, 1980;Schams, Prokopp & Barth, 1983).…”

Section: Introductionmentioning

confidence: 99%