The Effect of Experimental Salt Depletion and Aldosterone Load on Sodium and Chloride Concentration in the Sweat of Patients with Cystic Fibrosis of the Pancreas and of Normal Children

Siegenthaler, P; Haller, Jordan D.; Haller, R de; Hampai, A; Muller, A. F.

doi:10.1136/adc.39.203.61

Cited by 24 publications

(6 citation statements)

References 4 publications

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“…In normal individuals, sweat sodium can change by 30 mEq/L or more by varying salt intake or by administering aldosterone or aldosterone blockers (92,93). In normal individuals, sweat sodium can change by 30 mEq/L or more by varying salt intake or by administering aldosterone or aldosterone blockers (92,93).…”

Section: Sweat Chloride Clinical and Biological Relevancementioning

confidence: 99%

Detection of Cystic Fibrosis Transmembrane Conductance Regulator Activity in Early-Phase Clinical Trials

Rowe¹,

Accurso²,

Clancy³

2007

Proceedings of the American Thoracic Society

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Advances in our understanding of cystic fibrosis pathogenesis have led to strategies directed toward treatment of underlying causes of the disease rather than treatments of disease-related symptoms. To expedite evaluation of these emerging therapies, early-phase clinical trials require extension of in vivo cystic fibrosis transmembrane conductance regulator (CFTR)-detecting assays to multicenter trial formats, including nasal potential difference and sweat chloride measurements. Both of these techniques can be used to fulfill diagnostic criteria for the disease, and can discriminate various levels of CFTR function. Full realization of these assays in multicenter clinical trials requires identification of sources of nonbiological intra- and intersite variability, and careful attention to study design and statistical analysis of study-generated data. In this review, we discuss several issues important to the performance of these assays, including efforts to identify and address aspects that can contribute to inconsistent and/or potentially erroneous results. Adjunctive means of detecting CFTR including mRNA expression, immunocytochemical localization, and other methods are also discussed. Recommendations are presented to advance our understanding of these biomarkers and to improve their capacity to predict cystic fibrosis outcomes.

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Section: Sweat Chloride Clinical and Biological Relevancementioning

confidence: 99%

Detection of Cystic Fibrosis Transmembrane Conductance Regulator Activity in Early-Phase Clinical Trials

Rowe¹,

Accurso²,

Clancy³

2007

Proceedings of the American Thoracic Society

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show abstract

“…Na/K ratios have been determined in sweat and saliva during salt deprivation and have been used as a function test for adrenocortical insufficiency (Conn, 1949;Prader et al, 1955;Siegenthaler et al, 1964). In our hands these tests are difficult to standardize and the results are inconsistent.…”

Section: Cortisolmentioning

confidence: 99%

The adrenal cortex in childhood.

Visser¹

1966

Archives of Disease in Childhood

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“…5,6 This dissociation between sweat glands and kidneys in electrolyte regulation in cystic fibrosis (i n contrast to their concomitant disturbance in adrenal insufficiency) could be based on a peculiarity of the sweat glands as end-organs in this disease, but it may indicate that sweat glands differ from the kidneys in their requirement for aldosterone or for some other factor(s) acting in conjunction with aldosterone for proper regulation of electrolyte excretion. 5,6 This dissociation between sweat glands and kidneys in electrolyte regulation in cystic fibrosis (i n contrast to their concomitant disturbance in adrenal insufficiency) could be based on a peculiarity of the sweat glands as end-organs in this disease, but it may indicate that sweat glands differ from the kidneys in their requirement for aldosterone or for some other factor(s) acting in conjunction with aldosterone for proper regulation of electrolyte excretion.…”

mentioning

confidence: 99%

Electrolyte Excretion by Sweat Glands and Kidneys

May¹

1965

Am J Dis Child

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The Effect of Experimental Salt Depletion and Aldosterone Load on Sodium and Chloride Concentration in the Sweat of Patients with Cystic Fibrosis of the Pancreas and of Normal Children

Cited by 24 publications

References 4 publications

Detection of Cystic Fibrosis Transmembrane Conductance Regulator Activity in Early-Phase Clinical Trials

Detection of Cystic Fibrosis Transmembrane Conductance Regulator Activity in Early-Phase Clinical Trials

The adrenal cortex in childhood.

Electrolyte Excretion by Sweat Glands and Kidneys

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