The Effect of Extraction Conditions on Chemical and Thermal Characteristics of Kappa-Carrageenan Extracted from<i>Hypnea bryoides</i>

Al-Nahdi, None Zainab Mohammed; Al‐Alawi, Ahmed; Al-Marhobi, Insaaf

doi:10.1155/2019/5183261

Cited by 29 publications

(22 citation statements)

References 42 publications

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“…In G. turuturu, pH adjustment did not significantly impact the water-based extraction at room temperature, because whatever was being extracted had low molecular weight carbohydrates for which protonation was less relevant in terms of solubility than higher-molecular weight ones. At a near-boiling temperature, however, a linear increase of yield with pH suggested that alkalinity promoted extraction, which was expected since alkaline hydrolysis was one of the methods to dissolve cellulosic biomass and solvate their carbohydrates [44]. With ethanol in the solvent, this trend was reversed and we observed an almost-linear increase of yield and decreased pH.…”

Section: Discussionmentioning

confidence: 52%

Industry-Friendly Hydroethanolic Extraction Protocols for Grateloupia turuturu UV-Shielding and Antioxidant Compounds

et al. 2020

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Grateloupia turuturu is an invasive macroalga on the Iberian coast, known to produce bioactive compounds with different cosmeceutical bioactivities, namely UV shielding and antioxidants. The goal of this study was to optimize the extraction procedure of main bioactivities of this species with cosmetic potential, using Response Surface Methodology. Two Box–Behnken designs were used to evaluate the effect of ethanol concentration (0–50%), liquid-solid ratio, time, pH, and temperature on yield, UV absorbance, and antioxidant activity. Both optimizations showed a similar trend: aqueous extracts have higher yields and extracts performed with ethanol as part of the solvent have higher activities concerning UV absorbance and antioxidant activity. For all the extracts an absorption peak between 320 and 340 nm was observed. This data now allows further studies by narrowing the extracts worthful of characterization. The development of industry-friendly extraction methods allows the valorization of this invasive species, contributing for the potential creation of natural and eco-friendly products by the cosmetic industry while contributing to the restoration of affected environments.

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Section: Discussionmentioning

confidence: 52%

Industry-Friendly Hydroethanolic Extraction Protocols for Grateloupia turuturu UV-Shielding and Antioxidant Compounds

et al. 2020

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“…Fur showed the greatest shift in transition temperatures and in thermal hysteresis, probably due to the greater degradation of polysaccharide. A positive correlation between molecular weight and melting and gelling temperatures has been previously reported [ 15 , 40 ].…”

Section: Resultsmentioning

confidence: 54%

Impact of short-term heat treatment on the structure and functional properties of commercial furcellaran compared to commercial carrageenans

Eha¹,

Pehk²,

Heinmaa³

et al. 2021

Heliyon

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In the production of biopolymers, the processing operations (e.g. extraction and drying) involve some degradation of the polysaccharide-causing structural and functional changes in final products. In this study, short-term heat treatment (75–115 °C, 15 min) influence on commercial carrageenans' — furcellaran, κ-carrageenan, ι-carrageenan and a κ/λ-carrageenan — structure, molecular weight and gel rheology was studied. Compared with other carrageenans, commercial furcellaran that had undergone multiple heatings at high temperatures during production was found to be susceptible to polymer degradation. Heat caused the desulphation and degradation of furcellaran galactans and the molecular weight was significantly decreased, causing a drop in viscosity and gel hardness. The loss of the network cross-linking of furcellaran gels was confirmed by scanning electron microscopy. Carrageenan gel storage modulus values decreased with the increase in the temperature of the treatment. The greatest decrease in storage modulus values occurred with κ/λ-carrageenan gels, followed by ι-carrageenan > furcellaran > κ-carrageenan.

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“…Kappa-Carrageenan has a 3,6-AG bridge and one sulfate ester group. Because of this, it is less hydrophilic and less soluble in water [85]. Figure 6I,J show the interaction between Kappa-Carrageenan and the target M pro protein of SARS-CoV-2.…”

Section: Dolabellinmentioning

confidence: 99%

In Silico Analysis Using SARS-CoV-2 Main Protease and a Set of Phytocompounds to Accelerate the Development of Therapeutic Components against COVID-19

2022

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SARS-CoV-2, the virus that caused the widespread COVID-19 pandemic, is homologous to SARS-CoV. It would be ideal to develop antivirals effective against SARS-CoV-2. In this study, we chose one therapeutic target known as the main protease (Mpro) of SARS-CoV-2. A crystal structure (Id: 6LU7) from the protein data bank (PDB) was used to accomplish the screening and docking studies. A set of phytocompounds was used for the docking investigation. The nature of the interaction and the interacting residues indicated the molecular properties that are essential for significant affinity. Six compounds were selected, based on the docking as well as the MM-GBSA score. Pentagalloylglucose, Shephagenin, Isoacteoside, Isoquercitrin, Kappa-Carrageenan, and Dolabellin are the six compounds with the lowest binding energies (−12 to −8 kcal/mol) and show significant interactions with the target Mpro protein. The MMGBSA scores of these compounds are highly promising, and they should be investigated to determine their potential as Mpro inhibitors, beneficial for COVID-19 treatment. In this study, we highlight the crucial role of in silico technologies in the search for novel therapeutic components. Computational biology, combined with structural biology, makes drug discovery studies more rigorous and reliable, and it creates a scenario where researchers can use existing drug components to discover new roles as modulators or inhibitors for various therapeutic targets. This study demonstrated that computational analyses can yield promising findings in the search for potential drug components. This work demonstrated the significance of increasing in silico and wetlab research to generate improved structure-based medicines.

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The Effect of Extraction Conditions on Chemical and Thermal Characteristics of Kappa-Carrageenan Extracted fromHypnea bryoides

Cited by 29 publications

References 42 publications

Industry-Friendly Hydroethanolic Extraction Protocols for Grateloupia turuturu UV-Shielding and Antioxidant Compounds

Industry-Friendly Hydroethanolic Extraction Protocols for Grateloupia turuturu UV-Shielding and Antioxidant Compounds

Impact of short-term heat treatment on the structure and functional properties of commercial furcellaran compared to commercial carrageenans

In Silico Analysis Using SARS-CoV-2 Main Protease and a Set of Phytocompounds to Accelerate the Development of Therapeutic Components against COVID-19

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