The Effect of Fat Level of the Diet on General Nutrition

Deuel, Harry J.; Meserve, Emily R.; Straub, Evelyn; Hendrick, Cornelia; Scheer, Bradley T.

doi:10.1093/jn/33.5.569

Cited by 52 publications

(3 citation statements)

References 12 publications

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“…HFDs induce obesity not only in humans, but also in other species [10]. For example, in rats [11] and mice [12], the level of dietary fat has been related directly to an increase in body weight and body fat [13,14]. Animal models have been widely used in food and obesity experiments [15,16].…”

Section: Introductionmentioning

confidence: 99%

Dietary Options for Rodents in the Study of Obesity

2020

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Obesity and its associated metabolic diseases are currently a priority research area. The increase in global prevalence at different ages is having an enormous economic and health impact. Genetic and environmental factors play a crucial role in the development of obesity, and diet is one of the main factors that contributes directly to the obesogenic phenotype. Scientific evidence has shown that increased fat intake is associated with the increase in body weight that triggers obesity. Rodent animal models have been extremely useful in the study of obesity since weight gain can easily be induced with a high-fat diet. Here, we review the dietary patterns and physiological mechanisms involved in the dynamics of energy balance. We report the main dietary options for the study of obesity and the variables to consider in the use of a high-fat diet, and assess the progression of obesity and diet-induced thermogenesis.

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Section: Introductionmentioning

confidence: 99%

Dietary Options for Rodents in the Study of Obesity

2020

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“…Deuel et al (5) and Sheer et al (6) reported that rats fed diets containing high levels of fat had more rapid growth and more efficient reproductive and lactational performances than rats fed diets containing low concentrations of fats. However, French et al ( 7 ) found decreased reproductive performance of rats when the diet contained 23% corn oil compared to 4.470; the animals fed the high-fat diet produced smaller offspring, but lactational capacity was similar in the two groups of animals.…”

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confidence: 99%

“…This was to assure that the restricted rats had adequate proltein intake. 5 Grain diet is la nutritionally adequate diet maide primarily firom a corn-soy mixture (composition described in this journal, Vol. 130, p. 11146, footnote 1,1969).…”

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The Influence of High-Fat Diets on Estrous Cycles, Sperm Production and Fertility of Rats

Innami¹,

Yang²,

Mickelsen³

et al. 1973

Experimental Biology and Medicine

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Numerous studies have related nutrition to reproduction (1-4), but only a few dealt with the effect of high-fat diets on reproduction and these were confined to the requirement of essential fatty acids for reproductive performance. Deuel et al. (5) and Sheer et al. (6) reported that rats fed diets containing high levels of fat had more rapid growth and more efficient reproductive and lactational performances than rats fed diets containing low concentrations of fats. However, French et al. ( 7 ) found decreased reproductive performance of rats when the diet contained 23% corn oil compared to 4.470; the animals fed the high-fat diet produced smaller offspring, but lactational capacity was similar in the two groups of animals.Richardson et al. (8) reported that the number of young weaned by female rats was essentially the same when they were fed diets containing 3-18% fat, but was decreased when the diet contained 25740 fat.In the work reported herein, several reproductive parameters were measured in male and female rats fed a high (40%) fat diet ad libitum or restricted to give body weights similar to control rats fed a grain diet. In another experiment female rats were fed diets containing either 2.7 or 60% fat.Procedures. Rats in three experiments were 1Michigan Agric. Exp. Sta. J. article number 6183. Supported in part by an NIH gnant HD 05402-03 Ssl . housed individually in an animal quarter maintained at about 22' with 1 2 hr of light and 12 hr of darkness. Weanling female Osborne-Mendel rats were used in Expts 1 and 2, and weanling male Sprague-Dawley in Expt 3. Water was available at all times. The duration of the dietary treatments and numbers of rats used for the first and second experiment are indicated in Figs. 1 and 2, respec tively .In the (first experiment, rats were assigned at random to one of three groups, and fed a 40% fat diet4 ad libitum, or the same diet ad libitum until the rats reached 250-g body weight when feed intakes were restricted or a grain diet5 was offered on an ad libitum basis. Rats fed the restricted high-fat diet were fed to maintain body weight gain similar to grain-fed rats; usually this required 8-9 g of high-fat diet/rat/day.In the second experiment, rats were fed ad libitum a diet6 containing 2.7% fat or a 440% high-fat diet cornposition (in %): Fat, 40) ; casein, 25 ; mineral mix (Wesson, General Biochelmicals, Chagrin Falls, Ohio), 5 ; vitamin mix (vitamin fortification mixture, Nutritional Biochemicals, Cleveland, Ohio), 2.2 ; non-nutritive fiber, 2 ; aureomycin, 0.01 ; liver powder, 2 ; DL-methionhe, 0.25; sucrose, 23.54. For those fed restricted mlounts of this diet the % of 'casein was increased to 30 anld sucrose decreased to 118.54. This was to assure that the restricted rats had adequate proltein intake. 5 Grain diet is la nutritionally adequate diet maide primarily firom a corn-soy mixture (composition described in this journal, Vol. 130, p. 11146, footnote 1, 1969). 62.7% low fat diet composition (in %): Corn oil, 2.7; casein, 2 5 ; minerd mix (Weson, GeneralBi...

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Imbalance and Dietary Interrelationships in Nutrition

Elvehjem¹,

Krehl²

1947

JAMA

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The Effect of Fat Level of the Diet on General Nutrition

Cited by 52 publications

References 12 publications

Dietary Options for Rodents in the Study of Obesity

Dietary Options for Rodents in the Study of Obesity

The Influence of High-Fat Diets on Estrous Cycles, Sperm Production and Fertility of Rats

Imbalance and Dietary Interrelationships in Nutrition

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