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The Nl-silver derivative of sulfanilamide was prepared in small amount by Scudi2 for the purpose of identifying sulfanilamide. The yield was not high and the method employed was impractical for the preparation of the silver salt in quantity.For use in synthetic work, we have prepared the N '-silver derivatives of sulfanilamide, N4-acetyl sulfanilamide and sulfapyridine in quantity, and present detailed procedures here for those interested in this field. Experimental "-Silver Sulfanilamide.-Nl-Sodium sulfanilamide was prepared in 97y0 yield from sulfanilamide and alcoholic sodium hydroxide by the procedure which Marshall, Bratton and Litchfield3 used for the preparation of Nkodium sulfapyridine .Silver nitrate (14.0 g. or 0 082 mole) in 100 cc. of distilled water was added with vigorous stirring to a solution of N1sodium sulfanilamide (15.0 g. or 0.0773 mole in 100 cc. of water). Immediately a voluminous white precipitate formed which was filtered off with suction (using a fine filter paper) and washed with cold water until the washings were entirely free of silver ions. The washed precipitate was then spread upon a porous plate and allowed to dry in the dark for twenty-four hours. It was then removed from the plate and dried in the dark in a vacuum desiccator over potassium hydroxide sticks for forty-eight hours and finally in the oven at 100" for four hours.Anal. Calcd. for CeH702N2SAg: Ag, 38.68. Found: Ag, 39.47, 39.25.N1-Silver N4-Acetylsulfanilamide.-N4-Acetylsulfanil-amide4 (58.0 g. or 0.271 mole) was mixed with a small amount of water to make a thick paste. An equimolecular quantity of finely ground sodium hydroxide was then added to the paste. After the mixture had been stirred for a short time, complete solution was obtained. The solution was filtered and the filtrate poured into five times its volume of absolute ethyl alcohol and allowed to remain in the ice chest overnight. The heavy white precipitate which had Eormed was filtered off, washed with chilled absolute ethyl alcohol and dried in a vacuum desiccator over potassium hydroxide sticks. The hT1-sodium N4-acetylsulfanilamide was not purified but was converted directly into the N1silver derivative.Sixty-two grams (0.262 mole) of the N1-sodium salt was(1) The nomenclature used in this paper is that proposed by( 2 ) Scudi, I n d . Eng.dissolved in a small volume of distilled water. To the solution was added an aqueous solution containing an equimolecular quantity of silver nitrate. The "-silver derivative, which formed at once as a heavy white precipitate, was washed and dried exactly as described above for N1-silver sulfanilamide.Anal. Calcd. for CsHsOsN&Ag: Ag, 33.64. Found: Ag, 34.07, 34.17."-Silver Sulfapyridine.-N1-Sodium sulfapyridine was prepared in 80% yield by the method of Marshall, Bratton and Litchfield.8The sodium derivative, dissolved in a small volume of distilled water, was converted into N1-silver sulfapyridine with aqueous silver nitrate as described under "-silver N4-acetylsulfanilamide. The silver salt, which was white and gelatin...

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