The effect of [Fe3+]/[Fe2+] molar ratio and iron salts concentration on the properties of superparamagnetic iron oxide nanoparticles in the water/ethanol/toluene system

Jiang, Wen; Lai, Kuilin; Hu, Hao; Zeng, Xiaobo; Lan, Fang; Liu, Kexia; Wu, Yao; Gu, Zhongwei

doi:10.1007/s11051-011-0495-8

Cited by 82 publications

(44 citation statements)

References 30 publications

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“…Traditionally, the method starts from two precursors of iron with molar ratio Fe 3+ : Fe 2+ of 2:1, however a smaller ratio can be used to compensate the oxidation of Fe 2+ [19,20]. Jiang et al [20] has evaluated the influence of Fe 3+ : Fe 2+ molar ratio on the properties of iron oxide nanoparticles obtained using a derived co-precipitation method.…”

Section: Resultsmentioning

confidence: 99%

“…Jiang et al [20] has evaluated the influence of Fe 3+ : Fe 2+ molar ratio on the properties of iron oxide nanoparticles obtained using a derived co-precipitation method. When the ratio is below 1.75:1, the nanoparticles’ phase composition is pure magnetite, while the best magnetic properties are given by the samples obtained at around 1.5:1 molar ratio between the precursors.…”

Section: Resultsmentioning

confidence: 99%

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Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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Nanotechnology has been successfully used for the fabrication of targeted anti-cancer drug carriers. This study aimed to obtain Fe3O4 nanoparticles functionalized with Gemcitabine to improve the cytotoxic effects of the chemotherapeutic substance on cancer cells. The (un) functionalized magnetite nanoparticles were synthesized using a modified co-precipitation method. The nanoconjugate characterization was performed by XRD, SEM, SAED and HRTEM; the functionalizing of magnetite with anti-tumor substances has been highlighted through TGA. The interaction with biologic media has been studied by means of stability and agglomeration tendency (using DLS and Zeta Potential); also, the release kinetics of the drug in culture media was evaluated. Cytotoxicity of free-Gemcitabine and the obtained nanoconjugate were evaluated on human BT 474 breast ductal carcinoma, HepG2 hepatocellular carcinoma and MG 63 osteosarcoma cells by MTS. In parallel, cellular morphology of these cells were examined through fluorescence microscopy and SEM. The localization of the nanoparticles related to the cells was studied using SEM, EDX and TEM. Hemolysis assay showed no damage of erythrocytes. Additionally, an in vivo biodistribution study was made for tracking where Fe3O4@Gemcitabine traveled in the body of mice. Our results showed that the transport of the drug improves the cytotoxic effects in comparison with the one produced by free Gemcitabine for the BT474 and HepG2 cells. The in vivo biodistribution test proved nanoparticle accumulation in the vital organs, with the exception of spleen, where black-brown deposits have been found. These results indicate that our Gemcitabine-functionalized nanoparticles are a promising targeted system for applications in cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

et al. 2017

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“…On one hand, synthesis methods of the iron oxide core, stabilizer and reaction parameters have significant effects on the size and magnetic properties of SPIONs 52, 109-111. On the other hand, surface coating materials, functionalization materials and surface engineering methods significantly affect ultimate size in living fluid, biocompatibility, cell internalization and duration in cells 26, 30, 112, 113.…”

Section: Design Strategies Of Spions For Stem Cell Labelingmentioning

confidence: 99%

“…Based on the advantages of both coprecipitation and thermal decomposition method, our group explored a novel one-pot method with sodium oleate as both the surfactant and precipitant to synthesize monodispersed SPIONs in the water/ethanol/toluene system 110, 111, 120, 121. The convenient and mild reaction condition, high yield and narrow size distribution of the obtained SPIONs indicate this method has great potential for industry production.…”

Section: Synthesis Of Coresmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking

Li¹,

Jiang²,

Luo³

et al. 2013

Theranostics

Self Cite

434

307

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Stem cells hold great promise for the treatment of multiple human diseases and disorders. Tracking and monitoring of stem cells in vivo after transplantation can supply important information for determining the efficacy of stem cell therapy. Magnetic resonance imaging (MRI) combined with contrast agents is believed to be the most effective and safest non-invasive technique for stem cell tracking in living bodies. Commercial superparamagnetic iron oxide nanoparticles (SPIONs) in the aid of transfection agents (TAs) have been applied to labeling stem cells. However, owing to the potential toxicity of TAs, more attentions have been paid to develop novel SPIONs with specific surface coating or functional moieties which facilitate effective cell internalization in the absence of TAs. This review aims to summarize the recent progress in the design and preparation of SPIONs as cellular MRI probes, to discuss their applications and current problems facing in stem cell labeling and tracking, and to offer perspectives and solutions for the future development of SPIONs in this field.

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“…Rare publication on iron oxides is complete without a micrograph, often dubbed as "image." Fabrication of iron oxide nanoparticles with the properties tailored for specific application is in high demand in various technologically important areas, from high-density data storage to diagnostic medicine and targeted drug delivery, and the stunning TEM images play an important role in convincing the research community of being able to control the synthesis [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. It is worth noting, however, that although iron oxides are studied by countless researchers in numerous fields, analysis of these materials is far from being trivial.…”

Section: Nanoscale Analysis Of Iron Oxidesmentioning

confidence: 99%

TEM and Associated Techniques

Prozorov

2016

Iron Oxides

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Common Abbreviations ADF annular dark field AEM analytical electron microscopy BF bright field CCD charge-coupled device CCF cross-correlated function DF dark field DP diffraction pattern EELS electron energy-loss spectrometry EFI energy-filtered imaging EFTEM energy-filtered transmission electron microscopy EH electron holography ELNES energy-loss near-edge structure ETEM environmental transmission electron microscopy eV electron volt EXAFS extended X-ray absorption fine structure FEG field-emission electron gun FFT fast Fourier transform FIB focused ion beam FM fluorescence microscopy GIF Gatan Imaging filter TM HAADF high-angle annular dark field HRTEM high-resolution transmission electron microscopy HV high vacuum LC liquid cell MC minimum contrast MS multiple scattering MV megavolt PB phase boundary P/B peak to background ratio Iron Oxides: From Nature to Applications, First Edition. Edited by Damien Faivre.

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The effect of [Fe3+]/[Fe2+] molar ratio and iron salts concentration on the properties of superparamagnetic iron oxide nanoparticles in the water/ethanol/toluene system

Cited by 82 publications

References 30 publications

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Fabrication and Cytotoxicity of Gemcitabine-Functionalized Magnetite Nanoparticles

Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking

TEM and Associated Techniques

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