Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking

Li, Li; Jiang, Wen; Luo, Kui; Song, Hongmei; Lan, Fang; Wu, Yao; Gu, Zhongwei

doi:10.7150/thno.5366

Cited by 433 publications

(321 citation statements)

References 143 publications

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“…51,52 SPIONs display lower toxicity compared to the other contrast agents, such as gadolinium-based compounds, and are mostly considered safe. …”

Section: Spionsmentioning

confidence: 99%

Section: Spionsmentioning

confidence: 99%

“…51,52 SPIONs display lower toxicity compared to the other contrast agents, such as gadolinium-based compounds, and are mostly considered safe. 51 Examples of their application in MRI are clinically approved SPIONs, Feridex IV and Resovist, which could be used for liver imaging. The rationale behind their design is that once SPIONs are administered into human body, the particles are expected to accumulate within the liver and phagocytosed by Kupffer cells, the residing macrophages in the liver.…”

Section: Spionsmentioning

confidence: 99%

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Facilitating Translational Nanomedicine via Predictive Safety Assessment

et al. 2017

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Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nanobased therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.During the past decades, engineered nanomaterials (ENMs) have been widely used in biomedical applications, such as nanomedicine, bioimaging, and tissue engineering, because of their unique biophysicochemical properties.1,2 With regard to nanomedicine applications, ENMs could be formulated as drug carriers that deliver the therapeutic reagents within the human body and increase their bioavailability and blood circulation half-life.2 Moreover, these nanocarriers could be functionalized to deliver the drug specifically to the desired target tissues (e.g., tumors) and release the payload sustainably over long periods, thereby eliminating the necessity of multiple drug administration and reducing its cytotoxic side effects toward healthy cells.2 In addition to their implementation in drug delivery, ENMs could be used for diagnostic and imaging purposes that would help to monitor the disease and administer the treatment more accurately. 2Past research in nanomedicine has led to the design of various nanomaterial-based therapeutic and diagnostic systems that are being investigated in experimental stages (e.g., in vitro and in vivo) and clinical trials or are commercially available to the corresponding patients (Table 1). Most commercialized nanomaterial-based therapeutic reagents use lipids, proteins, and polymers that could self-assemble and biodegrade with few side effects.3 Because of high biocompatibility of lipids, several commercial liposome-drug formulations have been developed, mostly relying on polyethylene glycol (PEG)-conjugated lipids, such as DOXIL, AmBisome, Epaxal, and Inflexal V, and are under clinical trials focusing on various types of disease treatments. 4,5 Polymer-based nanoparticles (NPs) also present low toxicity, but their surface functionalization may affect their safety. The most commonly used materials include PEG, ploy(lactic-co-glycolic) acid (PLGA...

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“…51,52 SPIONs display lower toxicity compared to the other contrast agents, such as gadolinium-based compounds, and are mostly considered safe. …”

Section: Spionsmentioning

confidence: 99%

Section: Spionsmentioning

confidence: 99%

Section: Spionsmentioning

confidence: 99%

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Facilitating Translational Nanomedicine via Predictive Safety Assessment

et al. 2017

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“…34,47 Where Gd(III) is considered as a paramagnet, superparamagnets have a larger susceptibility to magnetization 48 and so are excellent candidates for contrast enhancement in MR images. 49 The most commonly used superparamagnets are superparamagnetic iron oxide nanoparticles (SPIONs). 49 In addition to their ability to enhance T 2 relaxation time of water, SPIONs have the benefit of being largely biologically compatible 50 (they are safely removed by existing metabolic pathways in cells) and can be detected using light and electron microscopy.…”

Section: Magnetic Resonance Imaging: Imaging With Magnetismmentioning

confidence: 99%

Cell Tracking Technologies for Acute Ischemic Brain Injury

Gavins

Smith

2015

J Cereb Blood Flow Metab

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Stem cell therapy has showed considerable potential in the treatment of stroke over the last decade. In order that these therapies may be optimized, the relative benefits of growth factor release, immunomodulation, and direct tissue replacement by therapeutic stem cells are widely under investigation. Fundamental to the progress of this research are effective imaging techniques that enable cell tracking in vivo. Direct analysis of the benefit of cell therapy includes the study of cell migration, localization, division and/or differentiation, and survival. This review explores the various imaging tools currently used in clinics and laboratories, addressing image resolution, long-term cell monitoring, imaging agents/isotopes, as well as safety and costs associated with each technique. Finally, burgeoning tracking techniques are discussed, with emphasis on multimodal imaging.

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“…Novel methods of synthesis of epitaxial films (pulsed laser deposition (PLD) method) and nanostructure investigation (transmission electron microscope (TEM), force microscopes) were being implemented [2,3]. It became apparent that nanoparticles of some magnetic oxides might find practical application in medicine, particularly, for enhancing the sensitivity of diagnostics methods (MRI) [4], and in therapy (hyperthermia treatment, targeted drug delivery etc.) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Properties and Applications of some Magnetic Oxide Based Nanoparticles and Films

Белоус¹,

Tovstolytkin

Solopan³

et al. 2018

Acta Phys. Pol. A

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The work highlights peculiar features of synthesis and summarizes important properties of nanoparticles and films based on two types of oxide magnets: with spinel and perovskite-type structures. The attention is drawn to the differences in the processes underlying the formation of crystalline phase in the materials of each group. It is shown that for the spinels, the formation of weakly agglomerated crystalline nanoparticles can occur in the process of synthesis, but for the perovskite-like magnets, the formation of crystalline nanoparticles requires additional high-temperature treatment. It is demonstrated that synthesized nanoparticles and films may find wide practical applications, particularly as the heat mediators in hyperthermia treatment therapy, as components of left-handed media, ferroelectric-ferromagnetic layered structures and composite microwave resonators. They also may be used as integral parts of composite structures, which possess magnetic-field-controlled properties and display giant magnetocaloric effect.

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Superparamagnetic Iron Oxide Nanoparticles as MRI contrast agents for Non-invasive Stem Cell Labeling and Tracking

Cited by 433 publications

References 143 publications

Facilitating Translational Nanomedicine via Predictive Safety Assessment

Facilitating Translational Nanomedicine via Predictive Safety Assessment

Cell Tracking Technologies for Acute Ischemic Brain Injury

Synthesis, Properties and Applications of some Magnetic Oxide Based Nanoparticles and Films

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