The effect of feed supplementation with a copper‐glycine chelate and copper sulphate on selected humoral and cell‐mediated immune parameters, plasma superoxide dismutase activity, ceruloplasmin and cytokine concentration in broiler chickens

Jarosz, Łukasz; Marek, Agnieszka; Grądzki, Z.; Kwiecień, Małgorzata; Kaczmarek, Beata

doi:10.1111/jpn.12750

Cited by 17 publications

(29 citation statements)

References 50 publications

(58 reference statements)

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“…The present results agreed with those reported by Jarosz et al (2018) who reported that SOD activity increased by feeding broiler chickens on diets rich in copper sulphate. It is well-known that Cu has the ability to regulate SOD activity in the tissues and body fluids of both growing and aged animals (Surai 2016).…”

Section: Antioxidants Responsesupporting

confidence: 94%

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Ali

2018

Journal of Animal and Poultry Production

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Two experiments were conducted to elucidate the effect of dietary copper supplementation on performance, physiological, hematological and antioxidant responses of day-old unsexed Japanese quail chicks (Coturnix coturnix Japonica). In each experiment, a total number of 250 quails were summited to five experimental treatments (50 chicks in five replicates each. The first one (control) was fed the basal diet while the other groups were fed the same diet supplemented with copper as cupric sulfate pentahydrate at levels of 50, 100, 150 and 200 mg/kg diet. In experiment 1 (Exp.1), chicks were fed the Cu-supplemented diets until 6 weeks of age whereas the supplementation period in experiment 2 (Exp.2) was for the first five weeks of age followed by a final period of one week during which birds fed the control basal diet. Results demonstrated that supplementation of copper sulfate to diets either or 6 (Exp. 1) or 5 weeks (Exp. 2) had significantly improved live body weight, weight gain, feed conversion ratio and low mortality rate of quail chicks. Hematological indices in terms of RBCs count, hemoglobin concentration, hematocrit, mean corpuscular volume, WBCs count and H /L ratio were significantly improves in quails fed Cu-supplemented diets up to 100 mg/Kg in Exp.1 and up to 150 mg/Kg in Exp. 2. Birds fed Cu-supplemented diets for six weeks (Exp. 1) up to 100mg/Kg had significantly higher plasma total protein, globulin, Immunoglobulins (Y , M , A) and high density lipoprotein (HDL) but lower plasma total cholesterol, triglycerides and low density lipoprotein (LDL) than the control ones. A similar trend was recorded for Exp. 2 quails, but plasma protein fractions were not significantly affected. In both experiments, blood reduced glutathione (GSH), superoxide dismutase (SOD) activity and total antioxidant capacity (TAC) were significantly increased with Cu-supplemented diets, while malondialdehyde (MDA) was significantly decreased in the experimental groups compared with the control. The obtained results indicate that dietary supplementation with cupric sulfate pentahydrate at levels up to 100 mg/kg could improve growth performance, antioxidant defense system, immunity and lower cholesterol content of growing Japanese quail.

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Section: Antioxidants Responsesupporting

confidence: 94%

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Ali

2018

Journal of Animal and Poultry Production

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Section: Introductionmentioning

confidence: 99%

“…Copper plays an important role in immune response processes (Chatterjee et al, 2009;Jarosz et al, 2018). Copper deficiency is associated with developmental disturbances of the lymphoid organs, a decrease in the percentage of T cells, impairment of their maturation in the spleen and reactivity to mitogens, and a reduction in antibody synthesis and the phagocytic index of cells (Das et al, 2014;Hong et al, 2002;Jarosz et al, 2018;Lim & Paik, 2006). Copper deficiency also delays the acute phase response, which is linked to impairment of synthesis of acute phase proteins (APP) such as ceruloplasmin, cytokine synthesis, and the generation of reactive oxygen species during phagocytosis (Das et al, 2014;Jarosz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Organic forms of this element show more favourable effects in poultry in terms of absorption and availability. Used as feed additives, they also exert positive health-promoting effects (Attia et al, 2011;Jarosz et al, 2018;Jegede et al, 2012). One of the organic copper compounds most commonly used as a feed additive for poultry is copper-methionine chelate (Cu-Met) (Chowdhury et al, 2004;Lim & Paik, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, these compounds have been shown to stimulate multiplication of beneficial intestinal bacteria, mainly Lactobacillus and Bifidobacterium, while reducing the number of harmful coliforms and decreasing mortality in birds (Mei et al, 2010). Differences in the bioavailability and effects of organic forms of copper on the immune system of poultry have prompted the search for new organic copper compounds containing modified chelate complexes with stronger effects on the immune system (Jarosz et al, 2018). One of these compounds, used as a feed additive, is copper-glycine chelate.…”

Section: Introductionmentioning

confidence: 99%

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The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

Jarosz

Ciszewski

Grabowski

et al. 2021

Food and Agricultural Immunology

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Copper has been shown to plays an important role in immune functions. The aim of the study was to determine the effect of inorganic and organic forms of copper on the concentrations of cytokines, acute phase proteins and prostanoids in the peripheral blood and liver of poultry. The concentration of copper in serum and tissues was also determined. A total of 900 1-day-old Ross 308 male chickens were used. The rearing period was 42 days. The material for analysis comprised samples of peripheral blood, liver, intestine and muscle of experimental chickens. The obtained results indicate that the supplementation of broilers feed with copper chelates promotes secretion of pro and anti-inflammatory cytokines. Increased synthesis of the immunoregulatory serum amyloid A (SAA) and alpha-1-acid glycoprotein (α-AGP) and prostanoids following the administration of copper-glycine chelates in the diet indicates the stimulatory effect of copper on cellular and humoral immune mechanisms.

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Dietary Copper Supplementation Increases Growth Performance by Increasing Feed Intake, Digestibility, and Antioxidant Activity in Rex Rabbits

Fan

Liu

Chen

et al. 2021

Biol Trace Elem Res

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The effect of feed supplementation with a copper‐glycine chelate and copper sulphate on selected humoral and cell‐mediated immune parameters, plasma superoxide dismutase activity, ceruloplasmin and cytokine concentration in broiler chickens

Cited by 17 publications

References 50 publications

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

Physiological and Antioxidant Responses of Japanese Quail to Dietary Copper Supplementation

The effect of feed supplementation with a copper-glycine chelate and copper sulphate on cellular and humoral immune parameters in chickens

Dietary Copper Supplementation Increases Growth Performance by Increasing Feed Intake, Digestibility, and Antioxidant Activity in Rex Rabbits

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