The objective was to determine whether changes in indicators of skin health among participants suffering from diabetes mellitus could be attributable to the type of sock worn (fiber content, structure). Changes in skin health over time (e.g. temperature, skin hardness, transepidermal water loss, stratum corneum hydration) can indicate improvement or deterioration, and these may be related to socks worn. Socks of different structure (single jersey, terry), and of fiber content (merino wool, cotton) were worn over a period of 22 weeks by participants suffering from diabetes mellitus. Each participant was their own control: change over time in skin hardness, stratum corneum hydration, transepidermal water loss and temperatures were monitored. Properties of the sock fabrics were measured as new and after use to determine effects of wear. Limited evidence of improved skin health was attributable to socks composed primarily of wool.