The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan

Dafaalla, Eman Ali Abuagla; Humeida, Amira Ahmed Khalid

doi:10.30574/wjarr.2021.10.3.0280

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study conducted in Sudan on Nigella sativa (black cumin seed) oil extract, which is known to have calcium antagonist antioxidant properties that are useful in the management of SCA, reported significant anti-sickling activity in vitro [ 198 ].…”

Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

“…Traditional use as "blood tonic" [193] Ceiba pentandra Traditional use as "blood tonic" [193] Moringa oleifera Antiurolithiatic properties [195] Nigella sativa Antioxidant properties [196] A study conducted in Sudan on Nigella sativa (black cumin seed) oil extract, which is known to have calcium antagonist antioxidant properties that are useful in the management of SCA, reported significant anti-sickling activity in vitro [198].…”

Section: Alchornea Cordifoliamentioning

confidence: 99%

See 1 more Smart Citation

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

View full text Add to dashboard Cite

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a congenital blood disorder characterized by considerable phenotypic diversity. It comprises a group of disorders, with sickle cell anemia (SCA) being the most prevalent and serious genotype. Although there have been some systematic reviews of global data, worldwide statistics regarding SCD prevalence, morbidity, and mortality remain scarce. In developed countries with a lower number of sickle cell patients, cutting-edge technologies have led to the development of new treatments. However, in developing settings where sickle cell disease (SCD) is more prevalent, medical management, rather than a cure, still relies on the use of hydroxyurea, blood transfusions, and analgesics. This is a disease that affects red blood cells, consequently affecting most organs in diverse manners. We discuss its etiology and the advent of new technologies, but the aim of this study is to understand the various types of nutrition-related studies involving individuals suffering from SCD, particularly in Africa. The interplay of the environment, food, gut microbiota, along with their respective genomes collectively known as the gut microbiome, and host metabolism is responsible for mediating host metabolic phenotypes and modulating gut microbiota. In addition, it serves the purpose of providing essential nutrients. Moreover, it engages in direct interactions with host homeostasis and the immune system, as well as indirect interactions via metabolites. Nutrition interventions and nutritional care are mechanisms for addressing increased nutrient expenditures and are important aspects of supportive management for patients with SCD. Underprivileged areas in Sub-Saharan Africa should be accompanied by efforts to define and promote of the nutritional aspects of SCD. Their importance is key to maintaining well-being and quality of life, especially because new technologies and products remain limited, while the use of native medicinal plant resources is acknowledged.

show abstract

Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Section: Alchornea Cordifoliamentioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

Targeted therapeutic management based on phytoconstituents for sickle cell anemia focusing on molecular mechanisms: Current trends and future perspectives

Islam,

Rauf,

Akash

et al. 2024

Phytomedicine

View full text Add to dashboard Cite

Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia

Gupta¹,

Chalotra²,

Dhanawat

et al. 2023

CTM

View full text Add to dashboard Cite

Background: Anaemia is the most common disease that affects mostly females and children and is most prevalent in developing countries. Among various causes sickle cell anaemia is one of them, which is a cause of concern. Sickle Cell Disease (SCD) causes problems like blockage of blood flow, causing pain, and fatigue and also leads to death. Objective: With the advancement in science, diseases that were once considered unable to cure can be stopped or prevented and, in some cases, also be cured. As current therapies for the treatment of sickle cell anaemia are limited, like blood transfusions, bone marrow transfusions, etc., a non-surgical method where plant extracts or compounds were found effective in stopping, preventing, and in some cases reversal of SCD. In this review, we tried to gather information about those plants and compounds. Method: Numerous surveys in the literature were performed to determine the plants which have shown their potential against SCD. Relevant peer-reviewed publications were searched through various databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc. Results: A total of more than 50 medicinal plants such as Acacia catechu, Alchornea cordifolia, Anchomanes difformis, Khayase negalensis, Terminalia catappa, etc., have been identified based on their potential against SCD, and 15 compounds such as Butylurea, Glyceraldehyde, Potassium cyanate, urea, etc., have also been identified which could work against SCD. These plants acting on sickle cell anemia on various pathways are also discussed. Conclusion: In this review, an approach was made to study those plants which have an effect against SCD, with proper mechanisms and compounds that show potency against this disease. So that better treatment options could be available for future generations.

show abstract

The effect of fixed oil extracts of Nigella sativa on sickle cells: An in-vitro study in Khartoum state -Sudan

Cited by 3 publications

References 11 publications

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Targeted therapeutic management based on phytoconstituents for sickle cell anemia focusing on molecular mechanisms: Current trends and future perspectives

Traditional Drugs Originating from Selected Medicinal Plants: An Intervention for Anaemia

Contact Info

Product

Resources

About