The Effect of Fluoride and Dietary Protein Levels on Calculus Formation, Alveolar Bone Loss, Selected Salivary Constituents and Fluoride Deposition in the Bones and Teeth

Zipkin, I.; Baer, Paul N.; Hawkins, G. R.; Zucas, Sergio Miguel; Mantel, Nathan

doi:10.1902/jop.1970.41.8.430

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…According to the studies collected, research on the effect of dietary proteins on periodontal disease has been performed mainly in rats (44)- (48) ,but Marsh rice rats (Oryzomys palustris) (49) and Mongolian gerbils (50) have also been used (Table 4). Generally, these studies have been based on dietary interventions with different amounts of proteins (44)- 47, (50) . As in interventions with varying lipid components, modifications of protein quantities are accompanied by changes in carbohydrate amounts in many cases (44), (46), (47), (50) .…”

Section: Proteinsmentioning

confidence: 99%

“…Generally, these studies have been based on dietary interventions with different amounts of proteins (44)- 47, (50) . As in interventions with varying lipid components, modifications of protein quantities are accompanied by changes in carbohydrate amounts in many cases (44), (46), (47), (50) .…”

Section: Proteinsmentioning

confidence: 99%

“…Results from some of these studies would indicate negative effects on alveolar bone for diets with very high protein contents (44), (50) . These include an investigation in female Sprague-Dawley rats (44) and another in Mongolian gerbils (47) .…”

Section: Proteinsmentioning

confidence: 99%

“…Curiously, changes in carbohydrates in these diets implied mainly higher variations in sucrose (13 vs. 65%) that could have had some negative effects, but consequences of hyperproteic diets seemed more important (44) . Similarly, in Mongolian gerbils fed a high-protein diet (also consisting of 62% casein), most animals showed significant osseous lesions in maxilla and mandible (P=0.02), although these revealed little or no evidence of calcareous deposits (50) .…”

Section: Proteinsmentioning

confidence: 99%

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Efecto de los macronutrientes en modelos animales de enfermedad periodontal: una revisión sistemática

2018

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Objetivos: La enfermedad periodontal es una de las enfermedades orales crónicas más comunes en todo el mundo y representa un importante problema de salud pública en muchos países. Las enfermedades periodontales incluyen periodontitis crónica y periodontitis agresiva que generalmente se debe a la inflamación de la encía causada por infecciones bacterianas. La nutrición podría ejercer un papel fundamental ya que participa en diferentes afecciones y enfermedades inflamatorias. Hasta ahora, solo algunos investigadores han investigado el papel de los nutrientes en el desarrollo y la progresión de la enfermedad periodontal, pero los resultados obtenidos a menudo son difíciles de comparar debido a la heterogeneidad de los estudios. Métodos: Este documento revisa sistemáticamente la literatura disponible en bases de datos hasta Febrero de 2018 sobre la relación entre macronutrientes y el desarrollo y progresión de enfermedades periodontales (periodontitis y gingivitis) en animales, con particular atención a los posibles mecanismos implicados en estas patologías. Resultados: Se encontraron un total de 5.484 publicaciones en la base de datos Pubmed. El análisis del título y resumen permitió seleccionar 88 artículos potenciales de acuerdo con los criterios de selección. No se encontraron artículos duplicados. La selección y lectura del texto complejo condujo a una cantidad final de 32 artículos. Conclusiones: Entre todos los macronutrientes analizados, aquellos que tienen algún efecto sobre el estrés oxidativo o el sistema inmune parecen ser importantes para la prevención de la enfermedad periodontal o la mejoría de la enfermedad periodontal. Por un lado, hay evidencia a favor de un papel positivo de la proporción de ácidos grasos n-3 en la dieta debido a sus efectos antioxidantes e inmunomoduladores. Por otro lado, las dietas ricas en grasas saturadas o hipercalóricas aumentan el estrés oxidativo o promueven la inflamación, por lo que deben evitarse.

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Section: Proteinsmentioning

confidence: 99%

Section: Proteinsmentioning

confidence: 99%

Section: Proteinsmentioning

confidence: 99%

Section: Proteinsmentioning

confidence: 99%

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Efecto de los macronutrientes en modelos animales de enfermedad periodontal: una revisión sistemática

2018

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Modification of dental caries and calculus in rats by fluoride and bicarbonate-phosphate-fluoride additions to dietary sugar

Luoma¹,

Meurman²,

Helminen³

et al. 1972

Archives of Oral Biology

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Dietetically provoked general and alveolar osteopenia in rats and its prevention or cure by calcium and fluoride

Ericsson

Ekberg

1975

J of Periodontal Research

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Male rats, 21‐100 days old at the start of different experiments, were kept for several weeks on synthetic diets, either adequate, or deficient in calcium (Ca) and at the same time low in protein and high in sucrose. For varying parts of the experimental periods the rats were given either dist. water, or water supplied with 2000 ppm Ca, 40 ppm fluoride (F), or both in a compatible form. Assessment was made of several parameters of the femoral bone density and of two histometric parameters of the alveolar bone density. The bone density in animals on Ca‐deficient diet was greatly improved by supplying either Ca or Ca+F with the drinking water. There was a tendency to higher mineral density with Ca+F supply than with Ca alone. Rats that had been on a high F, adequate diet were much more resistant to bone mineral depletion by a subsequent Ca‐deficient diet than were control rats that had been on the same diet without F. The alveolar bone generally reacted more strongly than the femoral bone to both deprivation and supplementation, and the tissue between the roots of one molar (M 2) more than the tissue between two molars (M 1–2). The correlations of alveolar bone parameters to femoral weight, ash, Ca and P content were all positive, in most cases statistically significant, and generally stronger for the M 2 than for the M 1–2 tissue. In an experiment where the deficient diet was supplied either as powder or as bread the results seemed to support the concept of an influence of masticatory force, particularly on the interdental bone septa. The connection between generalized osteopenia and alveolar bone loss and the roles of Ca and F are discussed.

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The Effect of Fluoride and Dietary Protein Levels on Calculus Formation, Alveolar Bone Loss, Selected Salivary Constituents and Fluoride Deposition in the Bones and Teeth

Cited by 4 publications

References 20 publications

Efecto de los macronutrientes en modelos animales de enfermedad periodontal: una revisión sistemática

Efecto de los macronutrientes en modelos animales de enfermedad periodontal: una revisión sistemática

Modification of dental caries and calculus in rats by fluoride and bicarbonate-phosphate-fluoride additions to dietary sugar

Dietetically provoked general and alveolar osteopenia in rats and its prevention or cure by calcium and fluoride

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