The Effect of Fluoride Ingestion on the Composition and Solubility of Mineralized Tissues of the Rat

McCann, H.G.; Bullock, Frederick A.

doi:10.1177/00220345570360031101

Cited by 66 publications

(11 citation statements)

References 11 publications

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“…With regard to resorption in dentine and dissolution in caries, the fluoridated crystal is much more acid-resistant. In addition, the larger asymmetric substituent, carbonate tends to be excluded from the crystal, further increasing stability [McCann and Bullock, 1957].…”

Section: Effect Of Fluoride On Mineral Propertiesmentioning

confidence: 99%

“…However, an increase in fluoride is usually accompanied by an increase in magnesium content [McCann and Bullock, 1957;Robinson et al, 1983]. This may relate to the fact that magnesium is at highest concentrations during secretion [Hiller et al, 1975] and like fluoride shows some selective uptake during transition [Robinson et al, 1984;Kirkham et al, 1988].…”

Section: Effect Of Fluoride On Mineral Propertiesmentioning

confidence: 99%

“…There is little direct information on fluorosed or fluorotic dentine mineral. Early reports did, however, suggest that it might contain reduced levels of carbonate and elevated magnesium similar to fluorotic enamel [McCann and Bullock, 1957]. The implications would be related as in enamel to a reduction in the supersaturation levels required for mineral precipitation and crystal growth with a concomitant reduction in acid solubility.…”

Section: Mineral Phasementioning

confidence: 99%

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The Effect of Fluoride on the Developing Tooth

et al. 2004

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This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel. Attention has been focused on mechanisms which, if compromised, could give rise to dental fluorosis. The literature is extensive and often confusing but a much clearer picture is emerging based on recent more detailed knowledge of odontogenesis. Opacity, characteristic of fluorotic enamel, results from incomplete apatite crystal growth. How this occurs is suggested by other changes brought about by fluoride. Matrix proteins, associated with the mineral phase, normally degraded and removed to permit final crystal growth, are to some extent retained in fluorotic tissue. Fluoride and magnesium concentrations increase while carbonate is reduced. Crystal surface morphology at the nano-scale is altered and functional ameloblast morphology at the maturation stage also changes. Fluoride incorporation into enamel apatite produces more stable crystals. Local supersaturation levels with regard to the fluoridated mineral will also be elevated facilitating crystal growth. Such changes in crystal chemistry and morphology, involving stronger ionic and hydrogen bonds, also lead to greater binding of modulating matrix proteins and proteolytic enzymes. This results in reduced degradation and enhanced retention of protein components in mature tissue. This is most likely responsible for porous fluorotic tissue, since matrix protein removal is necessary for unimpaired crystal growth. To resolve the outstanding problems of the role of cell changes and the precise reasons for protein retention more detailed studies will be required of alterations to cell function, effect on specific protein species and the nano-chemistry of the apatite crystal surfaces.

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Section: Effect Of Fluoride On Mineral Propertiesmentioning

confidence: 99%

Section: Effect Of Fluoride On Mineral Propertiesmentioning

confidence: 99%

Section: Mineral Phasementioning

confidence: 99%

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The Effect of Fluoride on the Developing Tooth

et al. 2004

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“…By contrast, higher fluoride levels were found in the femora of those rats who received the fluoride injections (group 3, Table V), reflecting the increased fluoride in corporation from the blood. It is known that no appreciable differences in the fluoride concentration were found in the dentino-enamel junction areas of teeth of subjects living in drinking water regions of 0.1-2.9 ppm F [Brudevold, 1962], whereas the fluoride concentration of the femur increases according to the intake [McCann and Bullock, 1957], Our findings suggest that the higher fluoride uptake by the enamel in the mo lar teeth of rats receiving fluoride intraperitoneally (group 3, table I) was due, to some extent, to surface action through the excreted salivary fluo ride released from the blood. In humans the ingestion of 300 ml of drink ing water containing 1 or 5.5 ppm F was accompanied by correspondingly increased fluoride levels in the stimulated saliva [Ericsson, 1969].…”

Section: Discussionmentioning

confidence: 99%

“…Twelve rats were fed a specially prepared low F diet, containing less than 1 ppm F [McCann and Bullock, 1957], and distilled water ad lib.…”

Section: Methodsmentioning

confidence: 99%

Fluoride Uptake by the Molar Teeth Surfaces of Mature Rats Following Intraperitoneal Fluoride Administration

Tori¹,

Gedalia²,

Sharav³

1970

Caries Res

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Fluoride uptake by the surface of rat molars was studied in vivo. Mature rats were selected in order to minimize endogenous fluoride supply to the tooth surfaces through the dentin via the dental pulp and were divided into 4 equal groups. One group was sacrificed at the start of the experiment and served as a base line. The three remaining groups were fed a low fluoride diet, with and without a daily dose of 0.167 mg F injected intraperitoneally as NaF, and a standard animal house diet, respectively. Six weeks from the beginning of the experiment all the rats were sacrificed. The surfaces of the mandibular and maxillary molar teeth were exposed to 0.2 N HCl for 30 min for removal of surface substance to be analyzed for fluoride. The surface layers were similar in thickness and weight in each group. A significant uptake of fluoride by the tooth surfaces occurred only in the group which received fluoride intraperitoneally. Low and normal fluoride intake, over a relatively short life period, did not appreciably increase the fluoride concentration of the molar teeth surfaces in mature rats.

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