The effect of folic acid supplementation with ferrous sulfate on the linear and ponderal growth of children aged 6–24 months: a randomized controlled trial

Medeiros, Desiree; Hadler, Maria Claret Costa Monteiro; Sugai, Andréa; Torres, Vinicius M.

doi:10.1038/ejcn.2014.220

Cited by 3 publications

(3 citation statements)

References 24 publications

(35 reference statements)

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“…Folic acid supplementation was shown in two RCTs in infants and children to have no impact on mortality ( Sazawal et al, 2006 ; Tielsch et al, 2006 ). In children over 6 months of age, two RCTs showed reduced incidence of acute diarrhoeal disease and lower respiratory tract infection ( Tielsch et al, 2006 ; Taneja et al, 2013 ) and one RCT showed increased total weight gain and WAZ scores with folic acid supplementation compared to placebo ( Medeiros et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review

Campion-Smith

Kerac

McGrath³

et al. 2020

PeerJ

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Background Infants under 6 months (U6M) contribute a significant proportion of the burden and mortality of severe malnutrition globally. Evidence of underlying aetiology in this population is sparse, but it is known that the group includes ex-preterm and low birthweight (LBW) infants. They represent a unique population given their dependence on breastmilk or a safe, secure alternative. Nutrition agencies and health providers struggle to make programming decisions on which interventions should be provided to this group based upon the 2013 WHO Guidelines for the ‘Management of Severe Acute Malnutrition in Infants and Young Children’ since there are no published interventional trial data focussed on this population. Interim guidance for this group might be informed by evidence of safety and efficacy in adjacent population groups. Methodology A narrative literature review was performed of systematic reviews, meta-analyses and randomised controlled trials of antimicrobial and micronutrient interventions (antibiotics, deworming, vitamin A, vitamin D, iron, zinc, folic acid and oral rehydration solution (ORS) for malnutrition) across the population groups of low birthweight/preterm infants, infants under 6 months, infants and children over 6 months with acute malnutrition or through supplementation to breastfeeding mothers. Outcomes of interest were safety and efficacy, in terms of mortality and morbidity. Results Ninety-four articles were identified for inclusion within this review. None of these studied interventions exclusively in severely malnourished infants U6M. 64% reported on the safety of studied interventions. Significant heterogeneity was identified in definitions of study populations, interventions provided, and outcomes studied. The evidence for efficacy and safety across population groups is reviewed and presented for the interventions listed. Conclusions The direct evidence base for medical interventions for severely malnourished infants U6M is sparse. Our review identifies a specific need for accurate micronutrient profiling and interventional studies of micronutrients and oral fluid management of diarrhoea amongst infants U6M meeting anthropometric criteria for severe malnutrition. Indirect evidence presented in this review may help shape interim policy and programming decisions as well as the future research agenda for the management of infants U6M identified as malnourished.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review

Campion-Smith

Kerac

McGrath³

et al. 2020

PeerJ

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show abstract

“…Folic acid supplementation was shown in two RCTs in infants and children to have no impact on mortality 122,123 . In children over 6 months of age, two RCTs showed reduced incidence of acute diarrhoeal disease and lower respiratory tract infection 123,124 and one RCT showed increased total weight gain and WAZ scores with folic acid supplementation compared to placebo 125 .…”

Section: Efficacymentioning

confidence: 99%

Peer Review #1 of "Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review (v0.1)"

2020

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Background. Infants under 6 months (U6M) contribute a significant proportion of the burden and mortality of severe malnutrition globally. Evidence of underlying aetiology in this population is sparse, but it is known that the group includes ex-preterm and low birthweight (LBW) infants. They represent a unique population given their dependence on breastmilk or a safe, secure alternative. Nutrition agencies and health providers struggle to make programming decisions on which interventions should be provided to this group based upon the 2013 WHO Guidelines for the 'Management of Severe Acute Malnutrition in Infants and Young Children' since there are no published interventional trial data focussed on this population. Interim guidance for this group might be informed by evidence of safety and efficacy in adjacent population groups. Methodology. A narrative literature review was performed of systematic reviews, meta-analyses and randomised controlled trials of antimicrobial and micronutrient interventions (antibiotics, deworming, vitamin A, vitamin D, iron, zinc, folic acid and oral rehydration solution (ORS) for malnutrition) across the population groups of low birthweight/preterm infants, infants under 6 months, infants and children over 6 months with acute malnutrition or through supplementation to breastfeeding mothers. Outcomes of interest were safety and efficacy, in terms of mortality and morbidity. Results. Ninety-four articles were identified for inclusion within this review. None of these studied interventions exclusively in severely malnourished infants U6M. 64% reported on the safety of studied interventions. Significant heterogeneity was identified in definitions of study populations, interventions provided, and outcomes studied. The evidence for efficacy and safety across population groups is reviewed and

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“…Many micronutrients (eg, folic acid, iodine, zinc, sodium, chloride, calcium, magnesium, vitamin A, phosphorous, manganese, and pyridoxine) are important for weight and length growth in infants (11–13). Several micronutrients, including iron, zinc, copper, iodine, selenium, chloride, folate, and vitamin A, are important for brain development and brain growth, which, in turn, are related to head growth (13–15), whereas calcium, phosphorus, and vitamin D are essential for bone mineralization (16).…”

mentioning

confidence: 99%

Intakes of Micronutrients Are Associated With Early Growth in Extremely Preterm Infants

Sjöström

Öhlund

Ahlsson

et al. 2016

J. pediatr. gastroenterol. nutr.

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Intakes of several micronutrients were inconsistent with recommendations. Even when considering macronutrient intakes and severity of illness, several micronutrients were independent predictors of early growth. Low intake of folate was associated with poor weight and length gain. Furthermore, high iron supply was associated with poor growth in length and head circumference. Optimized early micronutrient supply may improve early growth in extremely preterm infants.

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The effect of folic acid supplementation with ferrous sulfate on the linear and ponderal growth of children aged 6–24 months: a randomized controlled trial

Abstract: Folic acid had no effect on linear growth. The use of folic acid supplementation increased the monthly average weight gain and the gain in weight-for-age Z-score compared with the placebo group. This effect was independent of the dose of ferrous sulfate.

Cited by 3 publications

References 24 publications

Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review

Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review

Peer Review #1 of "Antimicrobial and micronutrient interventions for the management of infants under 6 months of age identified with severe malnutrition: a literature review (v0.1)"

Intakes of Micronutrients Are Associated With Early Growth in Extremely Preterm Infants

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