The effect of follicullar fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome

Al-Hussaini, Tarek K.; Abdelaleem, Ahmed A.; Elnashar, Ihab; Shabaan, Omar Mamdouh; Mostafa, Rashad M.; El-Baz, Mona A.H.; El-Deek, Sahar E M; Farghaly, Tarek

doi:10.1016/j.ejogrb.2017.11.003

Cited by 33 publications

(23 citation statements)

References 34 publications

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“…Several studies previously evaluated the effects of pesticide exposure on early IVF outcomes, with inconsistent results (Jirsová et al 2010;Mahalingaiah et al 2012;Al-Saleh et al 2009;Al-Hussaini et al 2018;Bloom et al 2017). A study on organochlorines pesticides and reproductive health outcomes in 99 women who had IVF showed that the levels of 1,1,1-trichloro-2,2,-bis(4-chlorophenyl)ethane (DDT) in follicular fluid were negatively associated with the number of diploid oocytes (Jirsová et al 2010).…”

Section: Discussionmentioning

confidence: 99%

“…A study on organochlorines pesticides and reproductive health outcomes in 99 women who had IVF showed that the levels of 1,1,1-trichloro-2,2,-bis(4-chlorophenyl)ethane (DDT) in follicular fluid were negatively associated with the number of diploid oocytes (Jirsová et al 2010). Another prospective study that examined the relationship between toxicants in reproductive fluid and IVF outcomes in 94 infertile couples found high concentrations of DDT, diazinon, and chlorpyrifos (CPF) (the most commonly used types of OP) in follicular fluid, and these were associated with lower number of oocytes retrieval (Al-Hussaini et al 2018). In contrast, other studies reported no associations between pesticide exposures and early reproductive outcomes (Mahalingaiah et al 2012;Al-Saleh et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Animal and in vitro studies suggested that exposure to OP disrupts reproductive function through inhibition of follicular growth, impaired gamete quality and oocyte maturation, and poor embryo development (Ding et al 2011;Tian et al 2000;Tian et al 2009). Few epidemiological studies to date examined the association between pesticide exposures and reproductive outcomes in women who sought ART, showing inconsistent results (Chiu et al 2018;Jirsová et al 2010;Mahalingaiah et al 2012;Al-Saleh et al 2009;Al-Hussaini et al 2018;Bloom et al 2017). Therefore, the present study used data from the China National Birth Cohort (CNBC) prospective study to explore the association between preconception OP exposure and reproductive health outcomes among women undergoing IVF.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

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BACKGROUND: Animal studies suggest that pesticide exposure elicits endocrine changes, increases embryo implantation failure, and decreases litter size. However, only a few epidemiological studies have evaluated the effects of pesticides on the outcomes of in vitro fertilization (IVF) pregnancies. OBJECTIVES: This study examined the associations between preconception organophosphate pesticides (OP) exposure and pregnancy outcomes among women undergoing IVF in a Chinese population. METHODS: This study included 522 women with infertility who underwent IVF. Women were recruited from a prospective study, the China National Birth Cohort (CNBC), from Shanghai, China, between July 2017 and December 2018. Demographic and clinical information were collected from medical records and through questionnaires. Preconception exposure to OP was assessed by measuring six nonspecific dialkylphosphate (DAP) metabolites [diethylthiophosphate (DETP), diethylphosphate (DEP), diethyldithiophosphate (DEDTP), dimethylthiophosphate (DMTP), dimethylphosphate (DMP), dimethyldithiophosphate (DMDTP)] in urine samples collected at recruitment. Generalized estimating equation (GEE) models were used to evaluate the associations between OP and pregnancy outcomes. RESULTS: Compared with women in the lowest quartile (Q 1) of individual DEP and R 4 DAP (the sum of DMP, DMTP, DEP, and DETP), women in the highest quartile (Q 4) had lower odds of successful implantation, clinical pregnancy, and live birth, and most of the negative trends were significant (p-trends <0:05). There were no significant associations between urinary DAP concentrations and early IVF outcomes, including total and mature oocyte counts, best embryo quality, fertilization, E 2 trigger levels, and endometrial wall thickness. CONCLUSION: Preconception OP exposure was inversely associated with successful implantation, clinical pregnancy, and live birth in women who underwent IVF.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Vinturache

et al. 2020

Environ Health Perspect

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“…The effect on humans was supported by only one clinical study documenting that a high level of MAL, in the follicular fluid in women, was correlated with thinner endometrial thickness and lower retrieval and fertilization. Thus pesticide exposure may also adversely affect embryological intracytoplasmic sperm injection outcomes (Al-Hussaini et al 2018).…”

Section: Effects Of Malathion On Male Reproductive Systemmentioning

confidence: 99%

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

Badr

2020

Environ Sci Pollut Res

111

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Organophosphorus insecticides toxicity is still considered a major global health problem. Malathion is one of the most commonly used organophosphates nowadays, as being considered to possess relatively low toxicity compared with other organophosphates. However, widespread use may lead to excessive exposure from multiple sources. Mechanisms of MAL toxicity include inhibition of acetylcholinesterase enzyme, change of oxidants/antioxidants balance, DNA damage, and facilitation of apoptotic cell damage. Exposure to malathion has been associated with different toxicities that nearly affect every single organ in our bodies, with CNS toxicity being the most well documented. Malathion toxic effects on liver, kidney, testis, ovaries, lung, pancreas, and blood were also reported. Moreover, malathion was considered as a genotoxic and carcinogenic chemical compound. Evidence exists for adverse effects associated with prenatal and postnatal exposure in both animals and humans. This review summarizes the toxic data available about malathion in mammals and discusses new potential therapeutic modalities, with the aim to highlight the importance of increasing awareness about its potential risk and reevaluation of the allowed daily exposure level.

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“…Moreover, some pesticides (such as TCDD ( 40 , 41 , 42 ), PCB ( 43 ), and permethrin ( 44 )) have a documented impact on the endometrium by increasing vascularization, cell proliferation, VEGF levels, and thus endometriosis (with prevalence of 0.8–6%) ( 1 ). However, other pesticides (cypermethrin ( 45 ), chlorpyrifos, malathion, diazinon, lindane, DDT, and pyrethroids ( 46 )) have the opposite effect by indirectly inhibiting endometrial proliferation or causing oxidative damage to the uterus.…”

Section: Pesticide Exposure and Female Fertilitymentioning

confidence: 99%

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

Cabry¹,

Merviel²,

Madkour

et al. 2020

Endocrine Connections

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The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.

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The effect of follicullar fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome

Cited by 33 publications

References 34 publications

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Urinary Organophosphate Metabolite Concentrations and Pregnancy Outcomes among Women Conceiving through in Vitro Fertilization in Shanghai, China

Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments

The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF

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