The effect of formulation and process variables on prepared etoricoxib ‎Nanosponges

Salman, Ahmed Hamed; Al-Gawhari, Fatima Jalal; Al-kinani, Khalid Kadima

doi:10.51847/q0qrkuv2kq

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…The saturated solubility of PA was measured by adding an excess amount of PA powder to 5g of each oil, surfactant, co-surfactant, and dissolution media in firmly closed little glass tubes. To achieve equilibrium, the tubes were shaken in a thermostatically controlled shaking water bath at 25°C and 37°C for 72 hours (17,18). Samples were centrifuged, then the supernatants were removed, suitably diluted with methanol, and examined using a UV/Vis spectrophotometer at the λmax of PA.…”

Section: Pre-formulation Studies Estimation Of Pa Saturation Solubili...mentioning

confidence: 99%

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Al-Rubaye,

Al-Kinani

2023

J Fac Med Baghdad

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Background: Prednisolone acetate is an ester form of prednisolone. It is used topically as an ophthalmic suspension to treat many inflammatory ocular conditions, where its absorption from suspension is highly variable and has poor dose accuracy. Objectives: The main objective of this research is to formulate and evaluate prednisolone acetate microemulsion for ophthalmic use to increase solubility, residence time, and corneal permeability of the drug to enhance patient compliance and treatment efficacy. Methods: Twenty-four prednisolone acetate-loaded microemulsion (0.5%w/w) formulas were prepared using oleic acid, isopropyl myristate as (oil phase) (1:1), tween 80, labrasol, and cremophor EL as (surfactant), ethanol, polyethylene glycol 400, propylene glycol, transcutol P as co-surfactant and Sörensen isotonic phosphate buffer saline pH 7.4 as the aqueous phase at different Smix ratios (1:1), (1:2) and (2:1) by aqueous titration method to construct pseudoternary phase diagram to determine the existence of microemulsion region. All the prepared formulas were subjected to different evaluation tests to determine the optimum formula. Results: observations of the microemulsion showed that it had a clear and transparent yellowish color, formulation F9 composed of oleic acid and isopropyl myristate in a ratio (1:1) as oil, twee80 as a surfactant, and propylene glycol: ethanol (1:1) in a ratio (2:1) as cosurfactant gave the best particle size (10.18nm), polydispersity index (0.2216), zeta potential (-25,91), % of transmittance (99.382%±0. 09), and drug content (100±0.16). Microemulsion formulation provided considerably higher permeability than the marketed eye drop suspension (Optipred®) and improved bioavailability. Conclusions: The microemulsion-containing prednisolone acetate is a promising ocular carrier for the controlled release of prednisolone acetate in treating anterior segment inflammation. Received: Dec. 2022 Accepted March 2023 Published: Oct.2023

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Section: Pre-formulation Studies Estimation Of Pa Saturation Solubili...mentioning

confidence: 99%

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Al-Rubaye,

Al-Kinani

2023

J Fac Med Baghdad

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Assessment and Outcome on Preparations, Characterization of Topical Targeted Nanosponge Based Drug Delivery: Critical Review

Burad,

Markad,

Kulkarni

et al. 2023

Asian J Pharm Clin Res

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The pharmaceutical Industry, and most of the drugs which come from synthetic chemistry possess poor water solubility and approximately 70% of drugs fall under such category. To improve solubility, drug absorption and bioavailability are a critical lookout for the formulation scientist. The current research activity for the development of dosage forms is concentrated on the development of particulate carrier systems such as microspheres and liposomes. Nanosponge is being prioritized to control the delivery of drug/APIs/phytoconstituents to particular the skin targetting. The drug delivery to skin can be prevented through the development of nanosponge. Topical nanosponge preparation can be delivered in the form of local anesthetics, anti-fungal, anti-acne, anti-wrinkle, etc. drugs. The present study highlights the developmental stages for the topical targeted nanosponge drug delivery. The review covers a different method of preparation, and evaluation of topical nanosponge drug delivery systems.

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Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

Parihar,

Prajapati

2023

Pharmacophore

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The effect of formulation and process variables on prepared etoricoxib ‎Nanosponges

Cited by 5 publications

References 13 publications

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Assessment and Outcome on Preparations, Characterization of Topical Targeted Nanosponge Based Drug Delivery: Critical Review

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability

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The effect of formulation and process variables on prepared etoricoxib ‎Nanosponges

Cited by 5 publications

References 13 publications

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Preparation and Characterization of Prednisolone Acetate Microemulsion for Ophthalmic Use

Assessment and Outcome on Preparations, Characterization of Topical Targeted Nanosponge Based Drug Delivery: Critical Review

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor &amp; Its Optimisation for Solubility and Stability

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Product

Resources

About

Response Surface Methodology for an Improved Nanoemulsion of Ivacaftor & Its Optimisation for Solubility and Stability