The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis

Shabani, Ehsan; Sayemiri, Korosh; Mohammadpour, Mohammadtaghi

doi:10.1016/j.pcd.2018.07.007

Cited by 60 publications

(47 citation statements)

References 44 publications

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“…Among the 31 studies, 11 studies (Chiavarini et al, ; Fleischauer et al, ; Guercio et al, ; Hu et al, ; Kodali & Eslick, ; Li et al, ; Turati et al, , ; Zhou et al, , ; Zhu et al, ) were about cancer and tumor outcomes (gastric cancer, colorectal cancer, upper aerodigestive tract cancer, prostate cancer, and colorectal adenomatous polyps), 13 studies (Emami et al, ; Khoo & Aziz, ; Kwak et al, ; Reinhart et al, ; Ried, ; Ried, Toben, et al, ; Sahebkar et al, ; Shabani et al, ; Stevinson et al, ; Sun et al, ; Wang et al, ; Warshafsky et al, ; Zeng et al, ) were about metabolic outcomes (serum total cholesterol [TC], high‐density lipoprotein [HDL], low‐density lipoprotein [LDL], triglycerides [TGs], fasting blood glucose [FBG], serum HbA1c, serum fructosamine, serum lipoprotein (a), and apolipoprotein B), seven studies (Reinhart et al, ; Ried, ; Ried et al, ; Rohner et al, ; Silagy & Neil, ; Wang et al, ; Xiong et al, ) were about cardiovascular outcomes (systolic blood pressure and diastolic blood pressure), and only one systematic review and meta‐analysis (Taghizadeh et al, ) was about serum C‐reactive protein levels. Finally, 50 unique outcomes extracted from the 16 most recent meta‐analyses were analyzed in this umbrella review, and the map of allium vegetable‐related outcomes is reported in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Then, 19,023 articles remained after removing the duplicates, and 18,992 articles were excluded after reviewing the titles and abstracts. Finally, 31 full-text articles (Chiavarini et al, 2016;Emami, Rouhani, & Azadbakht, 2017;Fleischauer, Poole, & Arab, 2000;Guercio, Turati, La Vecchia, Galeone, & Tavani, 2016;Hu et al, 2014;Khoo & Aziz, 2009;Kodali & Eslick, 2015;Kwak et al, 2014;Li, Ying, Shan, & Ji, 2018;Reinhart, Coleman, Teevan, Vachhani, & White, 2008;Reinhart, Talati, White, & Coleman, 2009;Ried, 2016;Ried, Frank, Stocks, Fakler, & Sullivan, 2008;Ried, Toben, & Fakler, 2013;Rohner, Ried, Sobenin, Bucher, & Nordmann, 2015;Sahebkar et al, 2016;Shabani et al, 2018;Silagy & Neil, 1994;Stevinson, Pittler, & Ernst, 2000;Sun, Wang, & Qin, 2018;Taghizadeh, Hamedifard, & Jafarnejad, 2018;Turati et al, 2014;Turati, Pelucchi, Guercio, La Vecchia, & Galeone, 2015;Wang, Yang, Qin, & Yang, 2015;Wang, Zhang, Lan, & Wang, 2017;Warshafsky, Kamer, & Sivak, 1993;Xiong et al, 2015;Zeng et al, 2012;Zhou, Ding, & Liu, 2013;Zhou et al, 2011;Zhu, Zou, Qi, Zhong, & Miao, 2014) were reviewed for further assessment.…”

Section: Re Sultsmentioning

confidence: 99%

“…The benefits of allium vegetable consumption have been reported by many studies; however, contradictory results still exist. There were inconsistencies among several meta‐analyses about the associations between allium vegetable consumption and cancer, metabolic outcomes, and other health‐related outcomes (Chiavarini, Minelli, & Fabiani, ; Sahebkar, Serban, Ursoniu, & Banach, ; Shabani, Sayemiri, & Mohammadpour, ; Turati, Guercio, Pelucchi, La Vecchia, & Galeone, ), and these differences might have resulted from the different participants, types of allium vegetables, duration of allium vegetable consumption, and other factors in each meta‐analysis. Recently, an umbrella review was published and reported that garlic had some positive effects on indicators and biomarkers of cardiovascular disease; however, other types of allium vegetables and other health‐related outcomes were not mentioned (Schwingshackl, Missbach, & Hoffmann, ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Wan

Li³

et al. 2019

Food Science & Nutrition

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Previously, our meta‐analysis and other studies have suggested that allium vegetable consumption is beneficial for health, but no umbrella review has been conducted to assess the evidence of the various health benefits of allium vegetable consumption. Therefore, we conducted this umbrella review on this topic. This umbrella review included a total of 16 meta‐analyses with 50 unique outcomes. The most beneficial cancer‐related outcome was shown for gastric cancer (risk ratio 0.78; 95% confidence interval [CI] 0.67–0.91). In addition, only 8 weeks of garlic consumption significantly decreased serum total cholesterol (weighted mean differences −17.20 mg/dl; 95% CI −23.10 to −11.30), and patients with dyslipidemia who consumed garlic experienced more benefits than the whole population. Diabetic patients with longer durations of garlic intake experienced more benefits in terms of fasting blood glucose (FBG), HbA1c, and serum fructosamine than healthy participants, and garlic intake was associated with blood pressure reduction in hypertensive patients but not in normotensive participants. Limited side effects of garlic, such as garlic odor and gastrointestinal complaints, were reported among the included meta‐analyses. Our results suggested that allium vegetables might be beneficial for cancer prevention. In particular, garlic was comparatively safe and is recommended as a long‐term dietary component for patients with dyslipidemia, diabetes, and hypertension.

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Section: Resultsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Wan

Li³

et al. 2019

Food Science & Nutrition

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“…In recent years, researchers have used the hydrolysis and other techniques to prepare antihypertensive peptides from food-derived proteins (Tu, Cheng, Lu, & Du, 2018). Many studies revealed that garlic has antitumor (Song & Milner, 2001), antimicrobial (Arbach et al, 2019;Horita et al, 2016), antioxidant (Chen & Huang, 2019), reducing blood lipid (Shabani, Sayemiri, & Mohammadpour, 2019), anticardiovascular disease (Amor et al, 2019), and antidiabetic activities. Garlic (Allium sativum L.) belongs to the genus Allium of the Liliaceae family, which has been widely planted all over the world, mainly for cooking and medicinal applications (Ebrahimi Pure, Ghods Mofidi, Keyghobadi, & Ebrahimi Pure, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Gao

Xue

et al. 2019

J Food Biochem

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Garlic protein (GP) was enzymatically hydrolyzed using pepsin and trypsin followed by the evaluation of antioxidant and angiotensin-converting enzyme (ACE) inhibitory activities of GP and its hydrolysates. The antihypertensive effects of GP and its hydrolysates were determined in vivo. The results showed that GP and its hydrolysates namely GPH-P (pepsin) and GPH-T (trypsin) possessed appreciable antioxidant and ACE inhibitory activities. The ACE inhibitory activity of GP, GPH-T, and GPH-P was in consistent with their antioxidant activities. GP and its hydrolysates offered significant protective effects against H 2 O 2 -induced oxidative damage (p < .05). In addition, the administration of GP, GPH-T, and GPH-P reduced the blood pressure in hypertensive rats. The mechanism might be to reduce blood pressure by inhibiting the activity of ACE, reducing the formation of ACEII, and protecting the activity of bradykinin. This study suggested that GP might be utilized as a promising functional food as antioxidant and antihypertensive agents. Practical applicationsGarlic (Allium sativum L.) is one of the oldest cultivated plants that belongs to the Liliaceae family and it has been used in cooking and medicinal applications. Large quantities of garlic residuals were produced with the development of the garlic essential oil industry. These residuals are highly rich in proteins and they can be used for the preparation of protein hydrolysates. Generally, hydrolysates are considered as a promising food supplement due to the enrichment of amino acids present in it.In this study, garlic proteins (GPs) and its hydrolysates retain effective antioxidant effects. They were found to reduce the blood pressure and prevent oxidative stress induced by H 2 O 2 . The information from this study could be used to develop a new nutritional supplement from GP and its hydrolysates to treat hypertension as well as prevent oxidative damage. K E Y W O R D SACE inhibitory activity, antioxidant, L02 cells, oxidative damage

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“…The garlic effects on both lipid and glucose levels have been increasingly reported (Table 3) as well as its therapeutic efficacy in patients suffering from cardiovascular diseases and diabetes [51]. Actually, daily garlic allicin supplementation (0.05-1.5 g) displayed a positive and sustained role in blood glucose, total cholesterol (TC), and high/low density lipoprotein (HDL-c/LDL-c) regulation in type 2 diabetes mellitus (T2DM) management [52].…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation

et al. 2019

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Garlic has been used for a long time in human history. Allicin, the main active compound present in freshly injured garlic, is enzymatically formed from alliin. Allicin has shown doubtless beneficial effects and even be conceived as medicine. The present review highlights allicin-associated studies. Indeed, clinical studies on healthy subjects have evidenced that standardized garlic treatment (900 mg/day) significantly reduces total cholesterol (TC) and low-density lipoprotein cholesterol (c-LDL). Besides, allicin also led to a marked improvement in mouth opening, burning sensation, and oral health-related quality of life on stage II oral submucous fibrosis patients. Interestingly, in children, allicin also has been proposed for thrush prevention and as an alternative antibiotic therapy. Nonetheless, there is particular attention to allicin bioavailability, given its high instability. Although clinical evidence has promoted allicin release from garlic powder tablets under simulated gastrointestinal conditions, garlic tablets are those that have provided less alliinase protection due to its fast disintegration, releasing low allicin amounts.

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The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis

Cited by 60 publications

References 44 publications

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation

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