The Effect of Gaseous Ozone in Infected Root Canal

Ajeti, Nova Nexhmije; Pustina-Krasniqi, Teuta; Apostolska, Sonja

doi:10.3889/oamjms.2018.102

Cited by 15 publications

(18 citation statements)

References 17 publications

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“…The main reason for rejection of the articles was the tested groups that did not match the Effect of ozone therapy in root canal disinfection Silva et al inclusion criteria. After a comprehensive reading, three studies were excluded due to the absence of control groups (Halbauer et al 2013, Ajeti et al 2018) and performance of inhibition zones (Anand et al 2015). Therefore, a total of eight studies were selected for the systematic review.…”

Section: Quality Assessmentmentioning

confidence: 99%

The effect of ozone therapy in root canal disinfection: a systematic review

et al. 2019

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Aim To answer the following focused question: ‘As regards microorganism load reduction for patients undergoing root canal treatment, is the use of ozone therapy comparable to conventional chemomechanical techniques using sodium hypochlorite (NaOCl)?’ Data sources A systematic review was conducted using controlled vocabulary and free‐text key words in the following databases: PubMed, Science Direct, Scopus, Web of Science and Open Grey until 2 November 2018. Additional studies were sought through hand searching of endodontic journals. Study eligibility criteria, participants and interventions The inclusion criteria comprised studies that compared microbial reduction in root canals after treatments with ozone and NaOCl in extracted mature human teeth or randomized clinical trials. Study appraisal and synthesis methods The quality assessment of included laboratory studies was performed with the following parameters: (i) sample size calculation, (ii) samples with similar dimensions, (iii) control group, (iv) standardization of procedures, (v) statistical analysis and (vi) other risk of bias. For randomized clinical trials, the qualitative analysis of the studies was performed from the bias risk assessment using the tool ‘Bias Risk Assessment of Randomized Controlled Studies’ Cochrane Handbook 5.0.2. Results The search resulted in 180 published studies. After removal of duplicate studies and full‐text analysis, eight studies were selected and seven were considered low risk of bias (seven ex vivo studies and one random clinical trial). Overall, the results demonstrated that ozone therapy provides significantly less microbial load reduction than NaOCl. As an adjunct in chemomechanical preparation, ozone was ineffective in increasing the antimicrobial effect of NaOCl. Ozone performance was strongly associated with the application protocol used: it is dose, time and bacterial strain dependent, besides the correlation with the use of complementary disinfection sources. Limitations A restricted number of randomized clinical trial was found, and the difference amongst the methodology of the studies did not allow a meta‐analysis to be performed. Conclusions and implications of key findings Although the selected studies had limitations, this review reached a satisfactory methodological and moderate evidence quality contributing to important preliminary information regarding ozone therapy. As regards load reduction of microorganisms for patients undergoing root canal treatment, ozone is not indicated neither to replace nor to complement the antimicrobial action of NaOCl.

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Section: Quality Assessmentmentioning

confidence: 99%

The effect of ozone therapy in root canal disinfection: a systematic review

et al. 2019

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“…In optimal doses, ozone can react with blood components and affect positively oxygen metabolism and cell energy, activating antioxidant defense systems (Bocci, 2004). In dentistry, ozone therapy has been used to treat caries (Lim and Ngeow, 2017), endodontic (Ajeti et al, 2018) and periodontal diseases (Walker et al, 1995), and temporomandibular joint dysfunction (Dray, 1995;Domb, 2014). Moreover, this therapy has been used during maxillofacial surgery to promote hemostasis, enhance local oxygen supply (Bianco et al, 2019), and minimize postoperative discomfort (Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Is ozone effective in reducing pain, edema, and trismus after third molar surgery? A systematic review

Silva

Almeida

Vieira

et al. 2020

RSD

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This study aimed to evaluate the efficacy of ozone as a supporting therapy in reducing pain, edema, and trismus after lower third molar extraction. The protocol was registered in PROSPERO. Six electronic databases (PubMed, Scopus, LILACS, SciELO, Embase, and Web of Science) were used. Only randomized clinical trials were included, without restriction of year, language, and publication status. The JBI tool was used to assess the risk of bias. The GRADE approach assessed the certainty of evidence. The search yielded 3386 results, from which only three articles were eligible. The studies were published between the years 2013 and 2017, resulting in a sample of 133 patients. Ozone was used in the form of gas or gel. All studies found significant results for pain reduction after one, three, and seven days. Success in reducing trismus and edema varied between studies. The risk of bias varied between moderate and low. All outcomes were classified as a very low level of certainty. Although presenting favorable results for pain reduction, there is insufficient evidence to indicate the use of ozone as a complementary therapy during the extraction of third molars.

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“…Among all the desirable characteristics of an endodontic irrigant, it is the only one that can dissolve organic matter. For this reason, it continues to be used and incorporated into new irrigation protocols (Ajeti et al, 2018; Zehnder, 2006). The major concern about NaOCl is its strong cytotoxicity (Lee and Huang, 2019).…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Sodium Hypochlorite Gel for Endodontic Use

Pinheiro

Almeida

Silva

et al. 2020

J Surfact & Detergents

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The sodium hypochlorite (NaOCl) strong cytotoxicity and the potential to cause accidents by extrusion are the main concerns about its use as root canal irrigant. NaOCl gel has been proposed to improve safety. This research aimed to develop and characterize a NaOCl gel formulation using a surfactant. Seven gels with 2.5% NaOCl were produced using sodium lauryl ether sulfate (SLES) with concentrations between 2.0% and 5.0%. The gels were characterized by pH, surface tension, wettability, viscosity, Fourier transform infrared spectroscopy (FT-IR), bactericidal potential, and organic tissue dissolution. The gels pH which concentration was between 2.0% and 4.5% did not differ significantly from the 2.5% NaOCl solution. The surfactant reduced surface tension by more than 50% in all the gels, without statistical difference between them. Wettability decreased as SLES percentage in NaOCl formulation increased. The SLES addition provided viscous formulations. FTIR analysis showed intermolecular interactions between the SLES and NaOCl. Only 3.0% and 3.5% gels showed significantly reduced bactericidal activity (15 AE 0.7). All gels presented significantly reduced organic matter dissolution rate compared to the NaOCl solution (>56.33 AE 2.88 min). SLES is a surfactant compatible with NaOCl and promising viscosifying agent.

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The Effect of Gaseous Ozone in Infected Root Canal

Cited by 15 publications

References 17 publications

The effect of ozone therapy in root canal disinfection: a systematic review

The effect of ozone therapy in root canal disinfection: a systematic review

Is ozone effective in reducing pain, edema, and trismus after third molar surgery? A systematic review

Development and Characterization of Sodium Hypochlorite Gel for Endodontic Use

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