The effect of gelatin and hydroxyapatite ratios on the scaffolds' porosity and mechanical properties

Razali, K.R.; Nasir, N. F. Mohd; Cheng, E. M.; Normahira, M.; Mazalan, M.; Wahab, Yufridin; Roslan, M. Riza

doi:10.1109/iecbes.2014.7047497

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…Likewise, the same phenomenon can be observed for samples containing HAp loaded in a polymeric network. The loading of hydroxyapatite caused the reduction of porosity of the hydrogel scaffolds, which is in accordance with earlier research [ 14 , 60 , 61 , 62 ]. The porosity decrease was more pronounced in the case of A50G50H/HAp, confirming the interaction between functional groups of alginate and HAp.…”

Section: Resultssupporting

confidence: 92%

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

et al. 2021

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Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material’s composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.

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Section: Resultssupporting

confidence: 92%

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

et al. 2021

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“…Considerable current research on bone substitute materials has, therefore, tried to combine both properties of osteogenesis with a polymer material. [26][27][28][29] One of the various polymeric materials used in performing bone grafts is GAG. GAG consists of sulfate and non-sulfate compounds.…”

Section: Discussionmentioning

confidence: 99%

The effects of Anadara granosa shell-Stichopus hermanni on bFGF expressions and blood vessel counts in the bone defect healing process of Wistar rats

Sari

Sudjarwo

Rahayu

et al. 2017

Dent. J. (Maj. Ked. Gigi)

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“…It can be inferred here that in a scaffold with a fixed amount of HA, the amount of the starch content added plays an important role in affecting the performance of the scaffold. On the other hand, manipulating the HA content also significantly altered the mechanical and porosity of bone scaffolds [ 22 , 75 ]. It was suggested by Chen et al [ 76 ] that the diversity in grain size exerts several effects typically on chemical composition and macroporous structures of the biocomposite scaffold.…”

Section: Starch/hydroxyapatite Composite Scaffoldmentioning

confidence: 99%

“…Additionally, HA has a Ca/P ratio that falls in the range of 1.50–1.67, which encourages bone regeneration [ 21 ]. HA by itself is brittle and difficult to shape, and thus biopolymer is usually added to enhance its strength, as proven in the previous studies [ 3 , 22 ]. The typical biopolymer for this purpose is collagen, which is relatively poor in its mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

The State of Starch/Hydroxyapatite Composite Scaffold in Bone Tissue Engineering with Consideration for Dielectric Measurement as an Alternative Characterization Technique

et al. 2021

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Hydroxyapatite (HA) has been widely used as a scaffold in tissue engineering. HA possesses high mechanical stress and exhibits particularly excellent biocompatibility owing to its similarity to natural bone. Nonetheless, this ceramic scaffold has limited applications due to its apparent brittleness. Therefore, this had presented some difficulties when shaping implants out of HA and for sustaining a high mechanical load. Fortunately, these drawbacks can be improved by combining HA with other biomaterials. Starch was heavily considered for biomedical device applications in favor of its low cost, wide availability, and biocompatibility properties that complement HA. This review provides an insight into starch/HA composites used in the fabrication of bone tissue scaffolds and numerous factors that influence the scaffold properties. Moreover, an alternative characterization of scaffolds via dielectric and free space measurement as a potential contactless and nondestructive measurement method is also highlighted.

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The effect of gelatin and hydroxyapatite ratios on the scaffolds' porosity and mechanical properties

Cited by 10 publications

References 14 publications

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite

The effects of Anadara granosa shell-Stichopus hermanni on bFGF expressions and blood vessel counts in the bone defect healing process of Wistar rats

The State of Starch/Hydroxyapatite Composite Scaffold in Bone Tissue Engineering with Consideration for Dielectric Measurement as an Alternative Characterization Technique

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