The effect of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices in rats with polycystic ovary syndrome

Amanat, Sasan; Ashkar, Fatemeh; Eftekhari, Mohammad Hassan; Tanideh, Nader; Doaei, Saeid; Koohpeyma, Farhad; Mokhtari, Maral

doi:10.5653/cerm.2020.04231

Cited by 14 publications

(14 citation statements)

References 50 publications

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“…In vivo study on rats with PCOS treated with soybean isoflavone-aglycone fraction demonstrated decreased IL-6 and TNF-α levels in ovarian tissue ( 25 ). Those findings were comparable with those of Amanat et al ( 45 ), who identified reduced levels of TNF-α in PCOS rat model compared with those in healthy rats. Theca cells, which make androgens, had increased proliferation due to increased TNF-α levels, which also contributed to hyperandrogenism ( 25 ).…”

Section: Effect Of Isoflavone As An Anti-inflammatory Agentsupporting

confidence: 91%

Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)

Raihanah,

Sukrasno,

Kurniati

2024

Biomed Rep

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Polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder manifested in women of reproductive age, is still being treated using drugs with side effects. As an alternative to these drugs, isoflavone, also identified as phytoestrogen, has anti-PCOS activity. Isoflavone can help relieve PCOS symptoms by lowering the level of testosterone, which causes hyperandrogenism, thereby normalizing the menstrual cycle and restoring normal ovarian morphology. Furthermore, isoflavone influences the improvement of the metabolic profile, which changes because of PCOS, as well as the reduction of inflammatory markers and oxidative stress. However, both significant and non-significant results have been generated on the activity of isoflavones in PCOS. The present review aims to discuss the existing literature on the effect of isoflavone on PCOS symptoms based on in vivo and clinical trial studies.

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Section: Effect Of Isoflavone As An Anti-inflammatory Agentsupporting

confidence: 91%

Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)

Raihanah,

Sukrasno,

Kurniati

2024

Biomed Rep

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“…Amanat et al. 99 reported the effects of genistein on IR, inflammatory factors and lipids in rats with polycystic ovary syndrome. Biochemical and histopathological analyses showed that genistein (20 mg/kg/day) significantly alleviated oxidation, inflammation, blood glucose and histopathological indexes in polycystic ovary syndrome rats.…”

Section: Flavonoids: Classification and Biological Propertiesmentioning

confidence: 99%

Bioactivity and mechanisms of flavonoids in decreasing insulin resistance

Zhou

Konigsberg

Hao

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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Flavonoids are ubiquitous compounds in nature and are found in many Chinese herbal medicines. Due to their biological activity, flavonoids show potential for decreasing insulin resistance (IR), thereby delaying the progression of diabetes and accompanying metabolic syndromes. This review focuses on the mechanisms of flavonoids decreasing IR: (1) the interaction between flavonoids and target proteins of the insulin signalling pathway; (2) bioactivities of flavonoids, such as anti-inflammatory, lipid-lowering and antioxidant. Meanwhile, we summarise the structural characteristics, structure activity relationships and biological activity of flavonoids, providing evidence for their potential in the treatment of IR. Here, we also analyse the potential and limitations of their therapeutic use.

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“…Decreased expression of muscle and adipose GLUT4 in diabetic persons is one of the most important reasons for IR, since it is well known that the absorption of glucose into cells depends on the help of membrane GLUT4. In IR animal models, berberine was found to improve insulin sensitivity by activating AMP-activated protein kinase [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Rani,

Chitme,

Kukreti

et al. 2023

Nutrients

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Background: The plant Tinospora cordifolia (TC), traditionally known as guduchi or giloy, is used for a number of health conditions as a nutritional supplement and rejuvenation medicine. Its nutritional supplementary products are traditionally recommended for a wide range of health issues, including diabetes, menstruation discomfort, fever, obesity, inflammation, and more. Unfortunately, there has not been extensive research into its effectiveness in treating or managing insulin resistance, lipid and carbohydrate metabolism, hormonal imbalance, and metabolic syndrome-associated polycystic ovary syndrome (PCOS). Methods: Consequently, the present study was designed to induce insulin resistance, dyslipidemia, hormonal abnormality, hyperglycemia, and menstrual disturbance of PCOS using dehydroepiandrosterone (DHEA) in mice and study the effect of oral TC extracts on these factors by using ancient and modern technologies. During the 21-day study, 6 mg/100 g/day of DHEA was given to female mice. Levels of glucose, insulin, lipids, and hormones were estimated. In addition to being seen with the naked eye, the morphological and microscopic changes were also observed on histology slides. Results: The study outcomes show that pretreatment with TC preparations significantly improved biochemical and histological abnormalities in female mice. Diestrus phase was only observed in DHEA-treated animals, while cornified epithelial cells were present in TC-treated mice. Pretreatment with TC satva showed significant (p < 0.001) reductions in body weight compared to placebo. Fasting blood glucose, 1-h OGTT, and 2-h OGTT levels were all significantly lower in TC satva- and oil-treated animals in comparison to the disease control group (p < 0.001). Treatment with TC extracts resulted in a normalization of estradiol, progesterone, and testosterone levels (p < 0.05). Treatment with TC extract improved lipid profiles (p < 0.001), LH/FSH ratios (p < 0.01), fasting insulin levels (p < 0.001), HOMA-IR (p < 0.001), HOMA-Beta (p < 0.001), and QUICKI (p < 0.001). Both macroscopic and microscopic alterations were seen to be restored after TC extract treatment. After being treated with TC satva, oil, and hydroalcoholic extract, the severity of PCOS decreased by 54.86%. Conclusions: These findings lead us to the conclusion that TC extracts and satva as nutritional supplements are useful for treating PCOS and associated symptoms. It is recommended that additional research be conducted to determine the molecular mechanism of action of TC nutritional supplements on PCOS-related changes in metabolic profiles. We also recommend further clinical studies to explore the clinical efficacy and effectiveness of TC nutritional supplements in treating and/or managing PCOS.

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The effect of genistein on insulin resistance, inflammatory factors, lipid profile, and histopathologic indices in rats with polycystic ovary syndrome

Cited by 14 publications

References 50 publications

Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)

Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)

Bioactivity and mechanisms of flavonoids in decreasing insulin resistance

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

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