The effect of Gilbert’s syndrome on the dispersions of QT and P-wave dispersion: an observational study

Cüre, Erkan; Yüce, Süleyman; Çiçek, Yüksel; Cüre, Medine Cumhur

doi:10.5152/akd.2013.180

Cited by 10 publications

(15 citation statements)

References 40 publications

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“…In our study, N1 was found to have a strong correlation with systolic and diastolic BP. HR has been reported to be an independent predictive factor for cardiovascular mortality [24,36]. An increase in HR of 5 beats/minute has been found to increase cardiac mortality by 17%, while the hypertensive subjects with a HR greater than 70 bpm have a threefold higher cardiovascular mortality risk [37].…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. It affects nearly 5-10% of young women. It is characterized by the presence of hirsutism, acne, anovulation, hyperandrogenism, polycystic ovaries, and infertility [1]. Many mechanisms have been reported to be responsible for the pathophysiology of PCOS. The condition is thought to be determined by complex interactions between the hypothalamic-pituitary-ovarian or hypothalamic-pituitary-adrenal axis functions and metabolic disorders, such as obesity, insulin resistance (IR), and compensatory hyperinsulinemia [2]. PCOS increases the prevalence of hyperglycemia, hypertension, and dyslipidemia [3], increasing thus the risk of developing cardiovascular diseases [4].Nesfatin-1 (N1) is derived from nucleobindin 2 (NUCB2), which is encoded by the NUCB2 gene. It is a newly identified peptide that has 82 amino acids [5]. It is released from several tissues including forebrain, hindbrain, brainstem, spinal cord, adipose tissues [6]. It has an anorexigenic effect and plays an important role in hypothalamic pathways such as regulating food intake, energy homeostasis, water intake, and body temperature [7,8]. In addition, it exerts cardiovascular and hypertensive effects [9]. It is closely related to glucose, insulin metabolism, and IR [5,10]. Several studies have demonstrated N1 to be associated with body mass index (BMI), IR, inflammatory stimulation in diabetes, hypertension, and PCOS [9][10][11]. It may also affect the control of the reproduction system, e.g. puberty onset and gonadotropin secretion [12]. ABSTRACTObesity, insulin resistance (IR), inflammation, and hyperandrogenism may lead to polycystic ovary syndrome (PCOS) and hypertension. Nesfatin-1 (N1) may be related to IR, obesity, and hypertension. Furthermore, a vitamin D (VD) deficiency is associated with hypertension and PCOS. We aimed to investigate N1 and VD levels in PCOS that have an effect on systolic and diastolic blood pressure (BP) and heart rate (HR). This study included 54 patients with PCOS and 48 age-body mass index (BMI)-matched healthy controls. PCOS was diagnosed according to clinical practice guidelines. Ferriman-Gallwey scores (FGS) were calculated, while N1, VD, and other hormonal and biochemical parameters were measured for all subjects. Systolic and diastolic BP was measured as well. HR was calculated using an electrocardiogram. The levels of N1 (p < 0.001), high-sensitivity C-reactive protein (hs-CRP) (p = 0.036), homeostasis model assessment as an index of insulin resistance (HOMA-IR) (p < 0.001), systolic (p < 0.001) and diastolic (p < 0.001) BP and HR (p < 0.001) in the PCOS group were significantly higher than in the control group. However, the VD levels of the PCOS group were lower than the control group (p = 0.004). N1 had a strong positive correlation with BMI, HOMA-IR, hs-CRP, luteinizing hormone, systolic and diastolic BP, and HR. VD levels were negatively correlated with HOMA-IR and luteinizing hormone. Elevated N1 and decreased VD levels may...

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Section: Discussionmentioning

confidence: 99%

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Şahin

Ural

et al. 2015

Biomol Biomed

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“…In addition, number of individuals in our study is quite enough for GS illness. Another study reported that level of LDL in GS group was lower than control group, whereas level of HDL in GS group was higher than control group 11 . In the same time that this study resulted similarly with our study, the lipid panel in the GS patients is not evaluated as primer; results are given in order to enforce other findings.…”

Section: Discussionmentioning

confidence: 91%

“…GS diagnosed according to previous studies [10][11][12] . Seventy-two patients diagnosed with GS (38 females, 34 males) who had applied to the internal medical clinic in the hospital were included in this study.…”

Section: Patientsmentioning

confidence: 99%

Lipid Profili, Serum Ürik Asit, Glukoz ve İnsülin Direnci Üzerine Gilbert"s Sendromunun Etkileri

Cüre¹,

Cüre²,

Kırbaş³

et al. 2014

Cukurova Medical Journal

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Purpose: The protective effect of bilirubin on atherosclerotic heart disease in Gilbert's syndrome (GS) is well known.The aim of the study was to evaluate whether the atherosclerotic risk factors such as uric acid (UA), insulin resistance, glucose and lipid profiles are reduced in patients with GS compared with healthy subjects. Material and Methods: Thirty-four male and 38 female a total of 72 GS patients and a similar age group of 72 healthy individuals (34 males and 38 females) were included in the study. Both groups were between 16-45 years old and all patients were were non-smokers and drinkers. The levels of UA, lipids, glucose, insulin and C-reactive protein (CRP) were examined. HOMA-IR index were estimated. Results: GS patient's UA is 4.2 ± 0.8 mg/dL, control group's UA is 4.8 ± 1.1 mg/dL. GS patient's HOMA-IR is 1.8 ± 0.6, control group's HOMA-IR is 2.0 ± 0.4. GS patients had significantly lower levels of UA (p < 0.001), insulin (p = 0.021), HOMA-IR (p = 0.039), triglycerides (TG) (p = 0.005), low-density lipoprotein (LDL) (p = 0.036) and CRP (p = 0.006) compared with the control group. Even insignificantly, GS patients had lower levels of total cholesterol whereas highdensity lipoprotein (HDL) (p < 0.001) was found to be higher. Conclusion: Our results shown that in GS patients, increased bilirubin levels are associated with decrease in UA, insulin, LDL, TG, and increased HDL. In GS patients, low level of UA, insulin and lipid profile may be contributed to cardioprotective effect.

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“…Another study reported that the measurements of P wave and QT interval were found to be lower in GS patients compared to the control group 65 . Both P-wave and QT dispersion are known as the difference between maximum interval and minimum interval by electrocardiography.…”

Section: Gs Reduces the Risk Of Heart Diseasementioning

confidence: 99%

“…P-wave dispersion can be used to determine the risk of atrial fibrillation. Increased QT dispersion can be seen in many patients suffering from cardiac diseases such as patients with left ventricular hypertrophy, patients with heart failure, including idiopathic dilated cardiomyopathy, patients with acute myocardial infarction, hypertensive patients and patients with aortic stenosis 65 . The decreased MPV, P-wave and QT dispersion in GS patients may be related of diminished cardiovascular events.…”

Section: Gs Reduces the Risk Of Heart Diseasementioning

confidence: 99%

Gilbert\\\\\\\'s Sendromu

Cüre¹,

Yüce²,

Cüre³

2014

Arşiv Kaynak Tarama Dergisi

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Gilbert's syndrome is a benign condition that does not progress to chronic liver disease or fibrosis. Gilbert's syndrome diagnosis should be considered in patients with chronic elevation of unconjugated bilirubin. In these patients the presence of hemolysis and other diseases of the liver should be excluded. Gilbert's syndrome is an autosomal recessive disease. The mutation of uridine diphosphate glucuronyl transferase is seen in 10-16% of the population. There is a 70-80% decrease in bilirubin glucuronidation. In cases of unexplained indirect hyperbilirubinemia with no history of drugs, smoking or alcohol use, Gilbert's syndrome should be considered. Firstly, hemolysis should be excluded. It has been reported that having increased levels of indirect bilirubin lowers the incidence of carotid plaque and coronary artery disease in patients with Gilbert's syndrome. The antioxidation and resistance to oxidative stress status of patients with Gilbert's syndrome is known to be high. However, Gilbert's syndrome is associated with breast and colon cancer. Several studies have reported that liver transplantation from a patient with Gilbert's syndrome had no harm to himself or to the recipient. An exact relationship between schizophrenia and Gilbert's syndrome has not been demonstrated. Gilbert's syndrome patients have a risk of breast and colon cancer so frequent follow up is recommended.

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The effect of Gilbert’s syndrome on the dispersions of QT and P-wave dispersion: an observational study

Cited by 10 publications

References 40 publications

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Nesfatin-1 and Vitamin D levels may be associated with systolic and diastolic blood pressure values and hearth rate in polycystic ovary syndrome

Lipid Profili, Serum Ürik Asit, Glukoz ve İnsülin Direnci Üzerine Gilbert"s Sendromunun Etkileri

Gilbert\\\\\\\'s Sendromu

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