The effect of Ginkgo biloba extract treatment in the Bcl-2 expression by osteoblasts in the femoral trabecular bone of Wistar rats with glucocorticoid-induced osteoporosis

Lucinda, Leda Marília Fonseca; Aarestrup, Beatriz Julião Vieira; Brandão, Joanna S.; Peters, Vera Maria; Reis, João Evangelista de Paula; Guerra, Martha de Oliveira

doi:10.1016/j.bjp.2014.07.015

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Four weeks following the surgical procedure, the histological sections showed evident bone regeneration and active bone formation in both unloaded and GB loaded CS scaffold groups with more abundant bone formation and less fibrous tissue encapsulation in the GB/PLGA/CS scaffold group. These results coincide with the results of previous studies performed by Oh SM et al and Lucinda et al which indicated respectively that GB extract stimulated the in vitro differentiation of osteoblast cells and inhibited their apoptosis by increasing the expression of the anti-apoptotic protein called Bcl-2 protein (18,32). GB extract was also found to promote healing of bone fractures, possess an antiosteoporotic activity, and it inhibits osteoclastic bone resorption (29,33).…”

Section: Discussionsupporting

confidence: 92%

Effect of Ginkgo Biloba Loaded Chitosan Scaffold on Healing of Bone Defects in Rabbit

El-Sayed,

El-Hak,

Nagui

et al. 2023

Alexandria Dental Journal

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INTRODUCTION:Critical sized bone defects do not heal completely by themselves and require intervention by using bone grafts or scaffolds. Chitosan (CS) is a widely used biomaterial for bone regeneration. Ginkgo biloba (GB) leaf's extract is thought to be effective in stimulating bone cells differentiation. Polylactic-co-glycolic acid (PLGA) nanoparticles are commonly used as drug delivery vehicles. The PLGA nanoparticles were loaded with GB and incorporated in CS sponge scaffold. OBJECTIVES: To evaluate the effect of GB loaded PLGA nanoparticles incorporated in CS scaffold on healing of critical sized bone defects in rabbit. MATERIALS AND METHODS: eighteen adult male New Zealand rabbits were randomly divided into 3 equal groups (six rabbits each): Group A (Control group), Group B (CS group) and Group C (GB+PLGA+CS group). Critical sized bone defects were performed in the edentulous area of rabbit mandibles (diastema). Group A: defects were left empty, Group B: defects were filled with unloaded CS scaffold, while in group C: defects were filled with CS scaffold incorporated with GB loaded PLGA nanoparticles. Animals were euthanized four weeks after surgery and the results were evaluated histologically and histomorphometrically. RESULTS: GB loaded scaffold had a great effect on promoting regeneration of bone within the defects. CONCLUSION: the GB loaded CS scaffold is effective in bone regeneration and the GB extract has an osteoinductive potential.

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Section: Discussionsupporting

confidence: 92%

Effect of Ginkgo Biloba Loaded Chitosan Scaffold on Healing of Bone Defects in Rabbit

El-Sayed,

El-Hak,

Nagui

et al. 2023

Alexandria Dental Journal

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“…In vivo studies confirm that the prevention of bone damage is through systematic regulation of osteoblastogenesis and osteoclastogenesis. Additionally, it altered the bone parameters, serum parameters, and proinflammatory cytokines in a dose‐dependent manner and prevents osteoporosis efficaciously (Li et al, 2020; Lucinda et al, 2014; Lucinda et al, 2017; Wu et al, 2016). This demands further investigations and clinical trials to prove its action.…”

Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

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Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

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“…Glucocorticoids induced osteoporosis-Review 206 medicinal plants approaches osteoporosis in different manner means some supply dietary calcium, some control the body's use of calcium, and some increase the level of certain hormones in the body [45] . Dark green vegetables are a viable source of dietary calcium and phytoestrogens (plant-derived compounds possessing estrogen-like activity) showed that they are promising alternatives to treat osteoporosis [2] .…”

Section: Management By Medicinal Plantsmentioning

confidence: 99%

“…Bone is continually remodeling itself by the action of osteocytes that stimulate osteoclasts activity which erode cavities in bone or inhibit the action of osteoblasts which synthesize a new bone matrix. The bone remodeling prevents fatigue damage and important in preserving calcium homeostasis and the loss of osteoblast -osteoclasts coupling lead to several metabolic bone diseases including osteoporosis, tumor related bone disease, rheumatoid arthritis [1,2] .…”

Section: Introductionmentioning

confidence: 99%

A Review on Glucocorticoids Induced Osteoporosis: Pathogenesis, Diagnosis and Management by Some Natural Plants

Khaliefa¹,

El-Desouky²,

Hozayen³

et al. 2016

IJFNS

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200 million person all over the world affected by osteoporosis as it is most common metabolic bone disorder. The general reason of bone loss are age and menopause, and the rates of bone loss variable between individuals. Physical activity and environmental factors as nutrition can contribute to bone health as they modify both peak bone mass and following bone loss. Medications embrace both antiresorptive and anabolic types. Antiresorptive medications acts by reducing rates of bone remodeling like estrogens, selective estrogen receptor modulators (raloxifene), bisphosphonates (alendronate, risedronate, and ibandronate) and calcitonins. Parathyroid hormone is the only anabolic medication. The nonmedical treatment must be used with pharmacologic treatment to maximize outcomes for osteoporotic patient. Some plant-derived natural products, mostly phytoestrogens (isoflavones, lignans, coumestanes, stilbenes) and many more novel estrogen-like compounds in plants have been greatly used to prevent depletion in bone mineral density. In this review an attempt has been made out to compile the mechanisms of glucocorticoids induced osteoporosis, the medicinal plants which are commonly utilized in osteoporosis with their prominent chemical ingredients and certain pharmacological actions.

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The effect of Ginkgo biloba extract treatment in the Bcl-2 expression by osteoblasts in the femoral trabecular bone of Wistar rats with glucocorticoid-induced osteoporosis

Cited by 5 publications

References 11 publications

Effect of Ginkgo Biloba Loaded Chitosan Scaffold on Healing of Bone Defects in Rabbit

Effect of Ginkgo Biloba Loaded Chitosan Scaffold on Healing of Bone Defects in Rabbit

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

A Review on Glucocorticoids Induced Osteoporosis: Pathogenesis, Diagnosis and Management by Some Natural Plants

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