The effect of Ginkgo biloba extract on 3-nitropropionic acid-induced neurotoxicity in rats

Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

“…The current study shows that one possible mechanism of this neuroprotection is related to the regulation of the DA genes. Previous studies have also reported that EGb 761 provides neuroprotection through the regulation of several genes in different neurodegenerative animal models (Augustin et al, 2009;Mahdy et al, 2011). Furthermore, its neuroprotection also involves the regulation of transcription factors related to dopaminergic neurons in an animal model of PD.…”

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

“…They concluded that the anti-inflammatory and antioxidant potential of Calendula officinalis might have played a neuroprotective role. Mahdy et al [190] explored the beneficial effect of Ginkgo biloba extract on 3-nitropropionic acid-induced neurobehavioral changes and striatal lesions. They concluded that the antioxidant and antiapoptotic potential of Ginkgo biloba extract might be responsible for the neuroprotective role.…”

Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders

“…Exhibiting activity as a neuroprotective compound, EGb 761 acted as antioxidant and anti-apoptotic agent in 3-NP-exposed rats and improved energy metabolism as well as down-regulating striatal glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and Bax and up-regulating striatal Bcl-xl in the experimental animal (Mahdy et al, 2011).…”