The Effect of Giving Extract Etanol of Kepok Banana Peel (Musa Acuminata) toward total Cholesterol Level on Male Mice (Mus Musculus L.) Strain Deutschland-denken-yoken (ddy) Obese

Abstract

Obesity is excess of weight due to accumulation of fat which can cause dyslipidemia. One of dyslipidemia sign is increasing of total cholesterol level. The saponin, tannin and flavonoid as antioxidants components within kepok banana peel are predicted could decrease total cholesterol level. This study aims to determine whether saponin, tannin and flavonoid in kepok banana peels are effective against total cholesterol level in obese mice. This study was a true experimental using 20 obese male mice (Mus musculus L.) strain Deutschland-Denken-Yoken (ddY) and divided in four groups, which are normal control group (K1), obese control group (K2), and groups that were given extract of kepok banana peel treatment with dose 8,4 mg/day (KP1) and 16,8 mg/day (KP2). The treatment were given in 14 days. Total cholesterol level of each group was measured by spectrophotometer. The results obtained p=0,000, in one-way ANOVA test. Furthermore, in the Post Hoc Test generally found that there was significant differences between groups. There is effect of giving kepok banana peel to decreased total cholesterol level of obese mice. The effect of kapok Banana peel extract level of 8.4 mg/day more effectively lower total cholesterol level compared to banana peel extract level of 16.8 mg / day. The anti-cholesterol effect of banana fiber ethanol extract proved to decrease total cholesterol in obesity male mice (Mus musculus L.) strain ddY.

The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice

“…Reduction in MDA levels in mice treated groups; confirm that antioxidants in banana act as anti-free radicals. The results of this research are in accordance with the recent study of Berawi and Bimandama, 2018 [44].…”

Production, application and health effects of banana pulp and peel flour in the food industry

“…For instance, the higher quantity of ash can be valuable in treating deficiencies of minerals caused by celiac disease (Presutti et al 2007). Additionally, several studies have shown the application of BPe as a low-cost precursor for producing materials such as anionic dye and heavy metal adsorbents (Mahindrakar and Rathod 2018;Munagapati et al 2018;Oyewo et al 2018;Singh et al 2018;Vilardi et al 2018), recovering phenolic compounds (Vu et al 2018), producing cellulose nanofibers (Costa et al 2018;Harini et al 2018;Tibolla et al 2018), as well as bioethanol (Berawi and Bimandama 2018;Prakash et al 2018) and pectin extract (Khamsucharit et al 2018). In the following sections, some of the exclusive added value components in banana are introduced.…”

Pharmacological Activities of Banana

“…This finding revealed the effectiveness of the peel extract in inhibiting the atherosclerotic process via suppressing the expression of chemo-attractant molecules and monocyte adhesion and thus the peel extract may be considered a novel therapeutic agent in preventing atherosclerosis [43]. A related study was conducted by [44], in which the effect of saponin, tannin, and flavonoid present in Kepok banana peel against total cholesterol level in obese male mice was measured. The researchers divided 20 obese male mice (Mus musculus L.) into four groups and treated them for 14 days.…”