The effect of GnRH administration/insemination time on follicular growth rate, ovulation intervals, and conception rate of Nili Ravi buffalo heifers in 7 –day-CIDR Co-synch

Haider, Sajjad; Chishti, Ghazanfar Ali; Mehmood, Muhammad Usman; Jamal, Muhammad; Mehmood, Khalid; Shahzad, Muhammad; Tahir, Muhammad Zahid

doi:10.1007/s11250-021-03003-8

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Buffalo pose a challenge for artificial insemination due to weak estrus signs and delayed ovulation [ 48 ]. However, there are still opportunities to overcome this challenge by utilizing timed artificial insemination during a specific ovulation window using protocols such as Ovsynch or a progesterone-based approach [ 49 ].…”

Section: Application Of Exogenous Gnrh In Controlled Breedingmentioning

confidence: 99%

“…However, administering GnRH/TAI at 72 h after a 7-day CIDR Co-synch may result in inadequate oocyte development when smaller follicles are subjected to ovulation, which could negatively affect embryonic and fetal survival because oocytes from small follicles have lower developmental competence compared to those from larger follicles [ 52 ]. In contrast, buffalo heifers receiving GnRH/TAI at either 72 or 84 h after CIDR removal showed good estrus intensity in 7-day CIDR Co-synch [ 48 ]. This is significant because estrus intensity positively affected conception rates in conventional farming systems [ 53 ].…”

Section: Application Of Exogenous Gnrh In Controlled Breedingmentioning

confidence: 99%

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Application of Exogenous GnRH in Food Animal Production

Uddin

Petrovski

Song

et al. 2023

Animals

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Over several decades, exogenous GnRH and agonists have been employed for controlling reproductive cascades in animals, and treating some reproductive morbidities. The administration of GnRH is used in animals to counter ovarian dysfunction, induce ovulation, and to increase conception and pregnancy rates. GnRH and its agonists are used in the treatment of cystic ovarian degeneration and repeat breeder syndrome. The development of protocols for GnRH administration by intramuscular injection, intramuscular or subcutaneous implants, and intravaginal deposition has empowered their clinical use worldwide. Currently, exogenous GnRH products are a central part of several pre- and post-breeding programs for the enhancement of fertility, including the control of estrous cycles and timing of ovulation, development of fixed-time artificial insemination protocols, improved embryo survival, and the treatment of reproductive morbidity. The aim of the present review is to summarize the application of exogenous GnRH agonists in food animal production.

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Section: Application Of Exogenous Gnrh In Controlled Breedingmentioning

confidence: 99%

Section: Application Of Exogenous Gnrh In Controlled Breedingmentioning

confidence: 99%

Application of Exogenous GnRH in Food Animal Production

Uddin

Petrovski

Song

et al. 2023

Animals

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Preovulatory follicular dynamics and ovulatory events following the use of GnRH 84 h after medroxyprogesterone acetate sponge removal in postpartum buffaloes

MEHMOOD,

CHISHTI,

WASEEM

et al. 2024

J. Reprod. Dev.

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Herein, we evaluated the effects of gonadotropin hormone-releasing hormone (GnRH) administration 84 h after medroxyprogesterone acetate (MAP) sponge removal on follicular growth, ovulation timing, and pregnancy per artificial insemination (AI) in cosynchronized postpartum Nili Ravi buffaloes. In this study, 58 Nili Ravi postpartum buffaloes (DIM = 103 ± 1.64) were randomly divided into two treatment groups (n = 29/treatment): GnRH-TAI-84 and TAI-84. All buffaloes were administered a MAP sponge for seven days. Upon MAP sponge removal, all the subjects received prostaglandin F 2α (PGF 2α ) and Timed AI (TAI) was performed 84 h after sponge removal. In the GnRH-TAI-84 group, the buffaloes received GnRH alongside insemination, whereas in the TAI-84 group, the buffaloes were inseminated without GnRH administration. Follicle diameter and blood estradiol levels were measured every 6 h from 72–108 h after MAP sponge removal. The animals were checked for pregnancy using ultrasonography 40 days after AI. Animals subjected to the GnRH-TAI-84 protocol had a higher follicular growth rate and preovulatory follicle size than those in the TAI-84 group. The follicular diameter was also larger in animals that received GnRH-TAI-84 than in those that received TAI-84 90 and 96 h after MAP sponge removal. Buffaloes in the GnRH-TAI-84 group had lower estradiol concentrations at 90, 96, 102, and 108 h than those in the TAI-84 group. Ovulation in GnRH-TAI-84 buffaloes occurred 11 h earlier than that in buffaloes from the TAI-84 group. A shorter interval between AI and ovulation in GnRH-TAI-84 buffaloes (14 h vs . 25 h) led to greater pregnancies per AI (62% vs . 17%) compared to buffaloes from the TAI-84 group.

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Efficacy of omitting initial GnRH in once-used CIDR co-synch protocol for the treatment of anestrus in buffaloes during low breeding season

Gautam,

Adhikari,

Shah

2024

Buffalo Bull.

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Progesterone-based hormonal protocols are effective to treat anestrus in buffaloes. However, most of those protocols are costly, thus, requiring a cost-effective protocol that minimizes handling frequencies. This study, therefore, evaluated the effectiveness of the ‘once-used CIDR co-synch protocol’ with or without initial GnRH for treating anestrus in buffaloes during low breeding season. Anestrous buffaloes (n=29) were divided into two Treatment groups. As a part of the ‘once-used CIDR co-synch protocol,’ the first group (T1, n=18) received an initial GnRH on a random day (day 0) while the second group (T2, n=11) did not receive it. On day 0, the once-used CIDR device was inserted intravaginally in both groups, with GnRH administered in T1 but omitted in T2. On day 7, during CIDR removal, each buffalo received PGF2α, and on day 10, GnRH was given, and fixed-timed artificial insemination (FTAI) was done. Ovarian status was assessed on d0 and on 8 to 9-day post-FTAI using transrectal ultrasonography. Plasma progesterone concentrations on 8 to 9-day post-FTAI were determined using ELISA. No significant differences in estrus expression, ovulation and pregnancy rates were observed between two Treatment groups, with overall rates of 93%, 69%, and 34.5%, respectively. However, the overall pregnancy outcome (from FTAI plus natural breeding of buffaloes that returned to estrus) up to 2 months post-FTAI was 48.3%. Parity affected the ovulation among treated buffaloes, with higher (P=0.04) ovulation rate in buffaloes ≤4th parity (79.2%) compared to >4th parity (20%). There were no differences in CL size and plasma progesterone concentrations during 8 to 9-day post-FTAI between two treatment groups. In conclusion, omitting the initial GnRH in ‘once-used CIDR Co-synch protocol’ proved equally effective as the protocol with initial GnRH for the treatment of anestrus in buffaloes during the low breeding season.

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The effect of GnRH administration/insemination time on follicular growth rate, ovulation intervals, and conception rate of Nili Ravi buffalo heifers in 7 –day-CIDR Co-synch

Cited by 3 publications

References 26 publications

Application of Exogenous GnRH in Food Animal Production

Application of Exogenous GnRH in Food Animal Production

Preovulatory follicular dynamics and ovulatory events following the use of GnRH 84 h after medroxyprogesterone acetate sponge removal in postpartum buffaloes

Efficacy of omitting initial GnRH in once-used CIDR co-synch protocol for the treatment of anestrus in buffaloes during low breeding season

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