The Effect of Graft Bone Particle Size on Bone Augmentation in a Rabbit Cranial Vertical Augmentation Model: A Microcomputed Tomography Study

Kon, Kazuhiro; Shiota, Makoto; Ozeki, Maho; Kasugai, Shohei

doi:10.11607/jomi.2804

Cited by 21 publications

(19 citation statements)

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“…We investigated the possible factors influencing the vertical coronal region's bone resorption by constructing linear mixed models. Interestingly, the results revealed statistically significant correlations between particle size and alterations in VFBL from T1 to T2; in particular, the large particle of DBBM led to less resorption influencing the VFBL, and it had greater ability to maintain facial alveolar bone stability, consistent with previous animal studies (Kon, Shiota, Ozeki, & Kasugai, ; Prieto et al, ).…”

Section: Discussionsupporting

confidence: 87%

Facial alveolar bone alterations and gray value changes based on cone beam computed tomography around maxillary anterior implants: A clinical retrospective study of 1–3 years

Zhou

Gao

Sheng

et al. 2020

Clinical Oral Implants Res

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Objectives:The purpose of this cone beam computed tomography (CBCT) study was to describe facial alveolar bone alterations and gray value (GV) changes around implants in aesthetic anterior maxilla with simultaneous guided bone regeneration (GBR) and to investigate potential influence of factors related to vertical alveolar bone stability, such as particle sizes of the deproteinized bovine bone mineral (DBBM) used. Materials and Methods:A retrospective study design was adopted. Four facio-palatal cross-sectional CBCT images of 166 implants from 124 patients who had maxillary anterior implants were obtained. Measurements of the vertical facial alveolar bone level (VFBL), horizontal facial alveolar bone thickness (HFBT), and GV were identified of 1-3 years. Then, correlation coefficients for those parameters were calculated. Finally, linear mixed models were established to investigate potential factors influencing vertical alveolar bone resorption.Results: Facial alveolar bone underwent fast bone modeling and remodeling during the first 6 months, with decreases of 1.00 ± 1.19 and 0.74 ± 0.86 mm in VFBL and HFBT in implant shoulder, respectively, and there was positive and significant correlation between the alterations in VFBL and HFBT1 (r s = .516, p = .000). Linear mixed models identified particle size of DBBM as a critical factor associated with vertical bone resorption (p = .000). The GV gradually increased during the follow-up period. Conclusions:Rapid and unavoidable peri-implant bone resorption usually happened during the first 6 months after implant placement. GBR is a predictable treatment for maxillary anterior implants, since GV has an increasing trend. Large bone particles of DBBM help maintain vertical alveolar bone stability. K E Y W O R D S bone regeneration, bone substitutes, clinical research, CT imaging, radiology, statistics | 477 ZHOU et al.

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Section: Discussionsupporting

confidence: 87%

Facial alveolar bone alterations and gray value changes based on cone beam computed tomography around maxillary anterior implants: A clinical retrospective study of 1–3 years

Zhou

Gao

Sheng

et al. 2020

Clinical Oral Implants Res

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“…Evidence is reported, that the size of a scaffold granule is a critical factor for bone healing response (Coathup, Cai, Campion, Buckland, & Blunn, ; Ghanaati et al, ; Jensen et al, ; Klüppel et al, ; Kon, Shiota, Ozeki, & Kasugai, ; Malinin, Carpenter, & Temple, ; Maté Sánchez de Val et al, ; Shapoff, Bowers, Levy, Mellonig, & Yukna, ; Sun et al, ). The reason for this is expected in a different surface‐to‐volume ratio.…”

Section: Introductionmentioning

confidence: 99%

Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet's induced membrane in a critical size defect model in the rat's femur

et al. 2019

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The Masquelet technique for the treatment of large bone defects is a two‐stage procedure based on an induced membrane. The size of a scaffold is reported to be a critical factor for bone healing response. We therefore aimed to investigate the influence of the granule size of a bone graft substitute on bone marrow derived mononuclear cells (BMC) supported bone healing in combination with the induced membrane. We compared three different sizes of Herafill® granules (Heraeus Medical GmbH, Wehrheim) with or without BMC in vivo in a rat femoral critical size defect. A 10 mm defect was made in 126 rats and a membrane induced by a PMMA‐spacer. After 3 weeks, the spacer was taken out and membrane filled with different granule sizes. After 8 weeks femurs were taken for radiological, biomechanical, histological, and immunohistochemical analysis. Further, whole blood of the rat was incubated with granules and expression of 29 peptide mediators was assessed. Smallest granules showed significantly improved bone healing compared to larger granules, which however did not lead to an increased biomechanical stability in the defect zone. Small granules lead to an increased accumulation of macrophages in situ which could be assigned to the inflammatory subtype M1 by majority. Increased release of chemotactic respectively proangiogenic active factors in vitro compared to syngenic bone and beta‐TCP was observed. Granule size of the bone graft substitute Herafill® has significant impact on bone healing of a critical size defect in combination with Masquelet's technique in terms of bone formation and inflammatory potential.

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“…Many experimental animal studies have been developed over the last decade, in order to increase long-term performance of dental implants (C. OGUNSALU & al [25], C. OGUNSALU & al [26], K. KON & al [27]).…”

Section: Discussionmentioning

confidence: 99%

Experimental model for optimizing dental implant therapy in the posterior maxilla

Nimigean¹,

Sălăvăstru²,

Nimigean³

et al. 2020

Rom Biotechnol Lett.

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This research aimed to develop an experimental animal model for the evaluation of the posterior maxillary alveolar bone and further selection of the design for a dental implant with high osseointegration potential.Ten dried skulls of common adult dogs, Canis familiaris, were used in this study. In order to achieve the experimental model, two working methods were performed: imaging morphometry and direct morphometry. The measurements were accomplished for the purposes of determining the dimensions of the buccal and palatal alveolar cortical bone in the target location, the maxillary premolar region. The width and height of available bone were also recorded. Data analysis was performed using Student's t-test (P ≤ 0.05) and the Stata MP/13 software.Comparable results were obtained by both imaging and direct morphometry methods. The experimental implant was customized from the dimensional point of view and considering the most appropriate implant design.

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The Effect of Graft Bone Particle Size on Bone Augmentation in a Rabbit Cranial Vertical Augmentation Model: A Microcomputed Tomography Study

Cited by 21 publications

References 0 publications

Facial alveolar bone alterations and gray value changes based on cone beam computed tomography around maxillary anterior implants: A clinical retrospective study of 1–3 years

Facial alveolar bone alterations and gray value changes based on cone beam computed tomography around maxillary anterior implants: A clinical retrospective study of 1–3 years

Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet's induced membrane in a critical size defect model in the rat's femur

Experimental model for optimizing dental implant therapy in the posterior maxilla

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