The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials

Sarkhosh-Khorasani, Sahar; Sangsefidi, Zohreh Sadat

doi:10.1186/s12937-021-00686-5

Cited by 16 publications

(9 citation statements)

References 134 publications

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“…In a meta-analysis of 17 RCTs involving grape polyphenol supplementation, significant increases in antioxidant capacity and SOD activity were observed in healthy volunteers. Interestingly, no differences were noted in other antioxidant enzyme markers [ 32 ]. In another study of healthy humans, a 4-week supplementation of acai berry juice significantly increased total blood antioxidant capacity, as well as catalase and GPX activities [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

et al. 2021

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Strawberries, a popularly consumed berry fruit, are rich in bioactive compounds with antioxidant effects. In this study, we examined the effects of two dietary achievable doses of strawberries on the antioxidant status and biomarkers of endothelial function in adults with features of metabolic syndrome and a confirmed low baseline of fruit and vegetable intake. In a 14-week randomized controlled crossover study, participants were assigned to one of three groups for four weeks separated by a one-week washout period: control powder, one serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples and health data were collected at baseline and at the end of each four-week phase of intervention. Thirty-three participants completed all three phases of the trial. Significant increases were observed in serum antioxidant capacity and superoxide dismutase activity as well as decreases in lipid peroxidation after both low and high dose strawberry phases when compared with the control phase. Significant decreases were also observed in soluble vascular cell adhesion molecule-1 and tumor necrosis factor-α with the high dose strawberry phase. These data confirm that consuming strawberries for four weeks significantly improves antioxidant status, endothelial function, and inflammation in adults with cardiometabolic risks.

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Section: Discussionmentioning

confidence: 99%

Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

et al. 2021

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“…A double-blind randomized clinical trial revealed that grape consumption increases the total antioxidant capacity in the body which will help to fight oxidative stress and inflammation (Sarkhosh-Khorasani et al, 2021). In another study, it is found that grape extract significantly attenuates the body weight and mass index, waist circumference, as well as waist-to-hip ratio and also lower TNF-α, and high sensitivity C-reactive protein levels (Parandoosh et al, 2020) .…”

Section: Clinical Studies Of Grapementioning

confidence: 99%

A systematic review on hepatoprotective potential of grape and polyphenolic compounds: molecular mechanism and future prospective

Khan¹,

Ibrahim²

2022

NRFHH

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The hepatoprotective potential of grape and polyphenols has been scientifically well demonstrated in several experimental studies. However, there is no systematic review performed on their hepatoprotective activity. Based on scientific evidence, the goal of this systematic review was to describe and make inferences on the therapeutic advantages of grape and polyphenols against various chemical hepatotoxicities. Grape and polyphenols from preclinical and clinical studies were included for the online search utilising electronic databases such as PubMed, Web of Science, Scopus, Springer Nature, and Google Scholar. The searched words and terms were: “Hepatotoxicity” OR “Hepatoprotective” OR “Liver injury” AND “Hepatotoxic drug” AND “Grape” OR “Grapefruit” OR “Grape seed” OR “Grape peels” OR “Bioactive compounds” OR “Polyphenols” AND “Preclinical studies” OR “Clinical studies”. A total of sixty-five studies were included based on the rigorous inclusion and exclusion criteria. The systematic review revealed that grape and polyphenolic compounds could significantly alleviate hepatic markers (ALP, ALT and AST), antioxidant status (CAT, GPx, GSH and SOD), hepatic anti-inflammatory status (TNF-α, IL-1, IL-6, COX-2, and NF-κB pathways) and apoptosis markers [caspase-3 (CASP) and caspase-9] in chemical induced-hepatotoxicity. Furthermore, improvements in the structural, functional, and physiological characteristics of the liver were observed after treatment with grape and polyphenols, reflecting modulation in the cellular and molecular alterations. Conclusively, this study supports the therapeutic potential of grape and polyphenols for the management of hepatotoxicity in various conditions based on available scientific evidence.

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“…A recent meta-analysis of random clinical trials demonstrated the effective role of PPs on oxidative stress and inflammation. The findings of this meta-analysis described the potential role of PPs in increasing tacrolimus (TAC) levels [ 54 ]…”

Section: Polyphenols In the Prevention And Treatment Of Different Met...mentioning

confidence: 99%

Polyphenols in Metabolic Diseases

et al. 2022

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Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo and in vitro, as well as reported clinical studies. Considering their free-radical scavenging and anti-inflammatory properties, these substances can be used to treat different kinds of conditions associated with metabolic disorders. Many symptoms of metabolic syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, as well as cancer and neurodegenerative disorders, are substantially relieved by dietary PPs. The present study explores the bioprotective properties and associated underlying mechanisms of PPs. A detailed understanding of these natural compounds will open up new opportunities for producing unique natural PP-rich dietary and medicinal plans, ultimately affirming their health benefits.

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The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials

Cited by 16 publications

References 134 publications

Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial

A systematic review on hepatoprotective potential of grape and polyphenolic compounds: molecular mechanism and future prospective

Polyphenols in Metabolic Diseases

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