The effect of growth hormone treatment on growth in zinc deficient rats

Dicks, D.; Rojhani, Arezoo; Cossack, Zafrallah T.

doi:10.1016/s0271-5317(05)80562-7

Cited by 11 publications

(1 citation statement)

References 61 publications

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“…However, in the study described here the concentration of IGF-1 in the serum of the Zn-deficient rats was reduced by a significant 28% despite elevated GH levels. Reduced IGF-1 concentrations in Zn deficiency were also unanimously reported by other authors in animals {Cossack 1984;1986;Oner, Bhaumick and Bala 1984;Bolze, Reeves, Lindbeck and Elders 1987;Dorup et al 1991;Heindl et al 1993;Dicks, Rojhani and Cossack 1993;Droke et al 1993) and in humans {Ghavami- Maibodi et al 1983;Cossack 1991;Nakamura, Nishiyama, Futagaishi-Suginohara, Matsuda and Higashi 1993), which were reversible following Zn repletion {Cossack 1984;1986;1988;Ghavami-Maibodi et al 1983;Bolze et al 1987;Nishi et al 1989). The cause of the reduced IGF-1 levels in Zn deficiency while GH concentrations in the serum are elevated is believed to be an impairment of the stimulating effect of GH on IGF-1 synthesis.…”

Section: Discussionsupporting

confidence: 72%

Influence of Alimentary Zinc Deficiency on the Concentration of Growth Hormone (GH), Insulin-Like Growth Factor I (IGF-I) and Insulin in the Serum of Force-Fed Rats

Roth¹,

Kirchgeßner²

1994

Horm Metab Res

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The study described here investigates the influence of a specific alimentary Zn deficiency on the concentration of growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin in the serum of force-fed rats. For this purpose 24 male Sprague-Dawley rats with an average bodyweight of 108 g were divided into 2 groups of 12 animals each. The Zn-deficient group and the control group received for 12 days a semi-synthetic casein diet with a Zn content of 1.3 and 25 ppm respectively. In order to prevent the reduced feed intake which occurs in Zn deficiency and the associated energy and protein shortage from interfering with the experimental parameters, all animals were fed 4 times daily by gastric tube. This made it possible to supply all animals with adequate-nutrients and to synchronise the feed intake exactly. After 12 days the depleted rats were in a severe state of Zn deficiency, as demonstrated by the reduction of Zn in the serum and the femur by 62% and 44% respectively and the 70% lower serum activity of alkaline phosphatase. In the Zn-deficient rats the concentration of GH in the serum was significantly increased by 78%, while IGF-1 and insulin were significantly reduced by 28% and 25% respectively. It is thought that the growth depression observed in the Zn-deficient rats in this study despite their identical feed intake is probably due to a reduced concentration of IGF-I and insulin and that the biological activity or the binding of GH to receptors is impaired in specific alimentary Zn deficiency.

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