The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism

Isidori, Andrea M.; Kaltsas, Gregory; Perry, Les; Burrin, Jacky M.; Besser, G. M.; Monson, John P.

doi:10.1046/j.1365-2265.2003.01759.x

Cited by 31 publications

(22 citation statements)

References 54 publications

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“…Our results may be explained by the duration of treatment that is much longer than the 6 -8 week treatment previously reported (14,30). It has been argued that changes in cortisol-binding globulin might explain changes in circulating cortisol levels after GH replacement therapy, but results have been inconsistent (31,32).…”

Section: Discussioncontrasting

confidence: 46%

GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

Sigurjónsdóttir¹,

Korányi²,

Axelson³

et al. 2006

eur j endocrinol

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Objective: In the past years the interaction of GH and 11bhydroxysteroid dehydrogenase (11bHSD) in the pathogenesis of central obesity has been suggested. Design: We studied the effects of 9 months of GH treatment on 11bHSD activity and its relationship with body composition and insulin sensitivity in 30 men with abdominal obesity, aged 48-66 years, in a randomised, double-blind, placebo-controlled trial. Methods: Urinary steroid profile was used to estimate 11bHSD type 1 and 2 (11bHSD1 and 11bHSD2) activities. Abdominal s.c. and visceral adipose tissues were measured using computed tomography. Glucose disposal rate (GDR) obtained during a euglycaemic -hyperinsulinaemic glucose clamp was used to assess insulin sensitivity. Results: In the GH-treated group the 11bHSD1 activity decreased transiently after 6 weeks (P , 0.01) whereas 11bHSD2 increased after 9 months of treatment (P , 0.05). Between 6 weeks and 9 months, GDR increased and visceral fat mass decreased. Changes in 11bHSD1 correlated with changes in visceral fat mass between baseline and 6 weeks. There were no significant correlations between 11bHSD1 and 11bHSD 2 and changes in GDR. Discussion: The study demonstrates that short-and long-term GH treatment has different effects on 11bHSD1 and 11bHSD2 activity. Moreover, the data do not support that long-term metabolic effects of GH are mediated through its action on 11bHSD.European Journal of Endocrinology 154 69-74

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Section: Discussioncontrasting

confidence: 46%

GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

Sigurjónsdóttir¹,

Korányi²,

Axelson³

et al. 2006

eur j endocrinol

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“…Nevertheless, it has been suggested that, at least in rats, this effect may be indirectly mediated by Tinduced changes in growth hormone secretion [41]. Growth hormone administration has been observed to reduce plasma CBG levels in humans in some [42,43], but not in other studies [44,45]. It is thus possible that the postpubertal decrease in CBG levels observed in human males [46] may be mediated by raised growth hormone rather than T levels.…”

Section: Effect Of Testosteronementioning

confidence: 84%

Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin

Mihrshahi

Lewis

Ali

2006

The Journal of Steroid Biochemistry and Molecular Biology

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“…This implicates that the activity of the 11 β -HSDs family, which interconvert 11-hydroxy and 11-keto steroids, could be another regulatory point in the activation or inactivation of 11-hydroxy and 11-keto androgens in the prostate [17]. The involvement of 11b-HSD in prostate physiology deserves future studies as it has already been shown to be crucial in several clinical conditions [18, 19]. …”

Section: Discussionmentioning

confidence: 99%

Sex Steroid Metabolism in Benign and Malignant Intact Prostate Biopsies: Individual Profiling of Prostate Intracrinology

Gianfrilli

Pierotti

Pofi

et al. 2014

BioMed Research International

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In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characterized the enzymatic profile of biopsies from patients with benign prostatic hyperplasia (BPH) or cancer (PC), focusing on 17β-hydroxy-steroid-dehydrogenases (17β-HSDs) and aromatase activities. Samples from 26 men who underwent prostate needle core biopsies (BPH n = 14; PC n = 12) were incubated with radiolabeled 3H-testosterone or 3H-androstenedione. Conversion was evaluated by TLC separation and beta-scanning of extracted supernatants. We identified three major patterns of conversion. The majority of BPHs revealed no active testosterone/oestradiol conversion as opposed to prostate cancer. Conversion correlated with histology and PSA, but not circulating hormones. Highest Gleason scores had a higher androstenedion-to-testosterone conversion and expression of 17β-HSD-isoenzymes-3/5. Conclusions. We developed an easy tool to profile individual intraprostatic enzymatic activity by characterizing conversion pathways in an intact tissue environment. In fresh biopsies we found that 17β-HSD-isoenzymes and aromatase activities correlate with biological behaviour allowing for morphofunctional phenotyping of pathology specimens and clinical monitoring of novel enzyme-targeting drugs.

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The effect of growth hormone replacement therapy on adrenal androgen secretion in adult onset hypopituitarism

Cited by 31 publications

References 54 publications

GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

Hormonal effects on the secretion and glycoform profile of corticosteroid-binding globulin

Sex Steroid Metabolism in Benign and Malignant Intact Prostate Biopsies: Individual Profiling of Prostate Intracrinology

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